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Molecular Diagnosis of Prosthetic Joint Infection

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Infected Total Joint Arthroplasty

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Abstract

Diagnosis of Prosthetic Joint Infection remains as a challenge in modern medicine. Conventional techniques lead to the diagnosis of many patients with a classical infectious syndrome, but differential diagnosis with other entities (particularly aseptic failure) is still a problem. Several molecular markers have been studied in the diagnosis of infection (like cytokines, procalcitonin, specific IgG, sICAM-1, VEGF or alpha2-Macroglobulin), and even for microbiological diagnosis (lipid S, PIA, icaADBC operon), with variable success. PCR-based genetic amplification procedures have also been studied for the detection of microbial genes in different clinical samples, and will be probably included in the next future as part of the diagnostic schemes for this kind of infections.

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Authors and Affiliations

  1. Bone and Joint Infection Unit, Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Av. Reyes Católicos 2, Madrid, 28040, Spain

    Jaime Esteban M.D., Ph.D., Diana Molina-Manso & Gema del-Prado

  2. Department of Orthopaedic Surgery and Traumatology, Hospital “La Paz”, Paseo de la Castellana 261, Madrid, 28046, Spain

    Enrique Gómez-Barrena M.D., Ph.D.

Authors
  1. Jaime Esteban M.D., Ph.D.
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  2. Diana Molina-Manso
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  3. Gema del-Prado
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  4. Enrique Gómez-Barrena M.D., Ph.D.
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Corresponding author

Correspondence to Enrique Gómez-Barrena M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Orthopedic Hospital Valdoltra, Ankaran, 6280, Koper, Slovenia

    Rihard Trebše

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© 2012 Springer-Verlag London

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Esteban, J., Molina-Manso, D., del-Prado, G., Gómez-Barrena, E. (2012). Molecular Diagnosis of Prosthetic Joint Infection. In: Trebše, R. (eds) Infected Total Joint Arthroplasty. Springer, London. https://doi.org/10.1007/978-1-4471-2482-5_19

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  • DOI: https://doi.org/10.1007/978-1-4471-2482-5_19

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