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Interactions Between Diffuse Low-Grade Glioma (DLGG) and Brain Plasticity

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Diffuse Low-Grade Gliomas in Adults

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Abstract

The traditional view in neurooncology is to see first the tumor, with very few considerations concerning the brain. However, to select the best treatment for each patient with a DLGG, that is, to optimize the “onco-functional balance,” the understanding of the natural history of this chronic disease is not sufficient. One should also study the reaction of the central nervous system elicited by the growth and migration of the glioma. Indeed, due to strong interactions between DLGG and the brain, cerebral adaptive phenomena often occur in order to maintain neurological and cognitive functions, namely, to compensate the spreading of this diffuse tumor. Here, the purpose is to investigate mechanisms underlying such brain plasticity, with the goal to tailor the optimal management according to the dynamic relationships between DLGG course and cerebral functional reorganization at the individual level. Beyond the fundamental interest, it is crucial for the (surgical) neurooncologist to improve his knowledge of brain hodotopy to elaborate new therapeutic strategies, such as multistage surgical approach, made possible thanks to cerebral remapping over years. Therefore, cognitive neurosciences seem to represent a precious help to neurooncology by opening new avenues to improve both quality of life and median survival in DLGG patients, that is, to move toward “functional neurooncology.”

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  1. Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France

    Hugues Duffau MD, PhD

  2. National Institute for Health and Medical Research (INSERM), U1051 Laboratory, Team “Brain Plasticity, Stem Cells and Glial Tumors”, Institute for Neurosciences of Montpellier, Montpellier University Medical Center, Montpellier, 34091, France

    Hugues Duffau MD, PhD

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  1. Hugues Duffau MD, PhD
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Correspondence to Hugues Duffau MD, PhD .

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  1. , INSERM U1051, Institute for Neurosciences of Montpelli, av. Augustin Fliche 80, Montpellier, 34295, France

    Hugues Duffau

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Duffau, H. (2013). Interactions Between Diffuse Low-Grade Glioma (DLGG) and Brain Plasticity. In: Duffau, H. (eds) Diffuse Low-Grade Gliomas in Adults. Springer, London. https://doi.org/10.1007/978-1-4471-2213-5_22

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  • DOI: https://doi.org/10.1007/978-1-4471-2213-5_22

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