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Definition
The variable (V) gene, or “variable,” is a leafconcept of the “GeneType” concept of identification (generated from the IDENTIFICATION Axiom) of IMGT-ONTOLOGY, the global reference in immunogenetics and immunoinformatics (Giudicelli and Lefranc 1999; Lefranc et al. 2004, 2005, 2008; Duroux et al. 2008), built by IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org) (IMGT® Information System). “Variable” identifies a gene that rearranges at the DNA level and codes the variable region of the variable domain (Variable (V) Domain) of an immunoglobulin (IG) or antibody or of a T cell receptor (TR) chain (Chain Type).
It is one of the four leafconcepts that are characteristics of the IG and TR loci (Lefranc and Lefranc 2001a, b), the other three being “diversity” (D), “joining” (J), and “constant” (C) (Diversity (D) Gene, Joining (J) Gene, Constant (C) Gene).
An IG or TR variable (V) gene has two possible and exclusive...
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References
Duroux P, Kaas Q, Brochet X, Lane J, Ginestoux C, Lefranc M-P, Giudicelli V (2008) IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm. Biochimie 90:570–583
Giudicelli V, Lefranc M-P (1999) Ontology for immunogenetics: the IMGT-ONTOLOGY. Bioinformatics 12:1047–1054
Lefranc M-P, Lefranc G (2001a) The immunoglobulin FactsBook. Academic, London, pp 1–458
Lefranc M-P, Lefranc G (2001b) The T cell receptor FactsBook. Academic, London, pp 1–398
Lefranc M-P, Giudicelli V, Ginestoux C, Bosc N, Folch G, Guiraudou D, Jabado-Michaloud J, Magris S, Scaviner D, Thouvenin V, Combres K, Girod D, Jeanjean S, Protat C, Yousfi Monod M, Duprat E, Kaas Q, Pommié C, Chaume D, Lefranc G (2004) IMGT-ONTOLOGY for immunogenetics and immunoinformatics. In Silico Biol 4:17–29
Lefranc M-P, Clément O, Kaas Q, Duprat E, Chastellan P, Coelho I, Combres K, Ginestoux C, Giudicelli V, Chaume D, Lefranc G (2005) IMGT-Choreography for immunogenetics and immunoinformatics. In Silico Biol 5:45–60
Lefranc M-P, Giudicelli V, Regnier L, Duroux P (2008) IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics. Brief Bioinform 9:263–275
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Lefranc, MP. (2013). Variable (V) Gene. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_681
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_681
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