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Electroporation

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Image-Guided Cancer Therapy

Abstract

Nonthermal irreversible electroporation (NTIRE) is a minimally invasive tissue ablation modality in which high field strength, nanosecond to millisecond long pulsed electric fields are delivered across the cell to produce nanoscale defects in the cell membrane and thereby induce cell death. An important attribute of this technique is its ability to ablate cells in volumes of tissues while leaving intact the extracellular scaffold, including the mechanical scaffold of blood vessels and ducts. This is a review of the technology with a special emphasis on medical imaging. The review contains a background on the technology, mathematical modeling for treatment planning, fundamental findings from animal studies, first clinical results, and aspects of medical imaging.

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Author information

Authors and Affiliations

  1. School of Computer Science and Engineering, Hebrew University of Jerusalem, Jerusalem, 91904, Israel

    Mohammad Hjouj

  2. Department of Medical Imaging, Al-Quds University, 51000, Abu-Dis, Palestine

    Mohammad Hjouj

  3. Department of Mechanical Engineering, University of California at Berkeley, Berkeley, CA, 94720, USA

    Boris Rubinsky

Authors
  1. Mohammad Hjouj
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  2. Boris Rubinsky
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Corresponding author

Correspondence to Mohammad Hjouj .

Editor information

Editors and Affiliations

  1. The Warren Alpert Medical School of Brown University, Department of Diagnostic Imaging Rhode Island Hospital, Providence, Rhode Island, USA

    Damian E. Dupuy

  2. Department of Surgery and Radiology Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Yuman Fong

  3. McMullen Consulting, LLC, Surprise, Arizona, USA

    William N. McMullen

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© 2013 Springer Science+Business Media New York

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Hjouj, M., Rubinsky, B. (2013). Electroporation. In: Dupuy, D., Fong, Y., McMullen, W. (eds) Image-Guided Cancer Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0751-6_4

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  • DOI: https://doi.org/10.1007/978-1-4419-0751-6_4

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0750-9

  • Online ISBN: 978-1-4419-0751-6

  • eBook Packages: MedicineReference Module Medicine

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