Abstract
We present an approach based on photoacoustic lifetime imaging (PALI) to map the distribution of oxygen partial pressure (pO2) in tissue. This method utilizes methylene blue, a dye widely used in clinical applications, as an oxygen-sensitive imaging agent. PALI measurement of oxygen relies upon pO2-dependent excitation lifetime of the dye. The technique maps the excited triplet state of oxygen-sensitive dye, thus reflecting the spatial and temporal distributions of tissue oxygen.
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References
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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
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Shao, Q., Punnoose, J.G. (2024). Photoacoustic Lifetime Imaging of Hypoxia. In: Gilkes, D.M. (eds) Hypoxia. Methods in Molecular Biology, vol 2755. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3633-6_10
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DOI: https://doi.org/10.1007/978-1-0716-3633-6_10
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Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-3632-9
Online ISBN: 978-1-0716-3633-6
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