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Genetic Association Studies in Host-Pathogen Interaction Analysis

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Host-Pathogen Interactions

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2751))

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Abstract

Studying host-pathogen interactions at a molecular level has always been technically challenging. Identifying the different biochemical and genetic pathways involved in the different stages of infection traditionally require complex molecular biology tools and often the use of costly animal models. In this chapter, we illustrate a complementary approach to address host-pathogen interactions, taking advantage of the natural interindividual genetic diversity. The application of genetic association studies allows us to identify alleles involved in infection progression or resistance. Thus, this strategy may be useful to unravel new molecular pathways underlying host-pathogen interactions. Here we present the general steps that might be followed to plan, execute, and analyze a population-based study in order to identify genetic variants affecting human exposition to pathogens.

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Author information

Authors and Affiliations

  1. Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Lleida, Spain

    Marina Laplana

  2. Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina, Universidad de Málaga, Málaga, Spain

    José Luis Royo & Luis Miguel Real

  3. Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain

    Luis Miguel Real

  4. Centro de Investigación en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain

    Luis Miguel Real

  5. Instituto de Biomedicina de Sevilla, Sevilla, Spain

    Luis Miguel Real

Authors
  1. Marina Laplana
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  2. José Luis Royo
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  3. Luis Miguel Real
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Corresponding author

Correspondence to José Luis Royo .

Editor information

Editors and Affiliations

  1. Department of Microbiology, University of Seville, Sevilla, Spain

    Carlos Medina

  2. Department of Microbiology, University of Seville, Sevilla, Spain

    Francisco Javier López-Baena

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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Laplana, M., Royo, J.L., Real, L.M. (2024). Genetic Association Studies in Host-Pathogen Interaction Analysis. In: Medina, C., López-Baena, F.J. (eds) Host-Pathogen Interactions. Methods in Molecular Biology, vol 2751. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3617-6_2

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  • DOI: https://doi.org/10.1007/978-1-0716-3617-6_2

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3616-9

  • Online ISBN: 978-1-0716-3617-6

  • eBook Packages: Springer Protocols

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