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Practical Considerations for Total-Body PET Acquisition and Imaging

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Positron Emission Tomography

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2729))

Abstract

The world’s first total-body PET/CT system has been in routine clinical and research use at UC Davis since 2019. The uEXPLORER total-body PET scanner has been designed with an axial field-of-view long enough to completely encompass most human subjects (194 cm or 76 inches long), allowing for a 15–68-fold gain in the PET signal collection efficiency over conventional PET scanners. A high-sensitivity PET scanner that can image the entire subject with a single bed position comes with new benefits and challenges to consider for efficient and practical use. In this chapter, we discuss the common clinical and research imaging protocols implemented at our institution, along with the appropriate technical and practical considerations of total-body PET imaging.

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References

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Financial Support

Funding for this work was provided by NIH grant R01 CA206187, which is supported by NCI, NIBIB, and the Office of the Director, and by R01 CA249422.

Disclosure

UC Davis has a research agreement and a sales-based revenue sharing agreement with United Imaging Healthcare. No other potential conflicts of interest relevant to this article exist including employment, royalties, stock options, or patents.

Author information

Authors and Affiliations

  1. Department of Radiology, University of California-Davis, Sacramento, CA, USA

    Benjamin A. Spencer, Kristin McBride, Heather Hunt, Terry Jones, Simon R. Cherry & Ramsey D. Badawi

  2. Department of Biomedical Engineering, University of California-Davis, Davis, CA, USA

    Benjamin A. Spencer, Simon R. Cherry & Ramsey D. Badawi

Authors
  1. Benjamin A. Spencer
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  2. Kristin McBride
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  3. Heather Hunt
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  4. Terry Jones
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  5. Simon R. Cherry
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  6. Ramsey D. Badawi
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Corresponding author

Correspondence to Benjamin A. Spencer .

Editor information

Editors and Affiliations

  1. School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK

    Timothy H. Witney

  2. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada

    Adam J. Shuhendler

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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Spencer, B.A., McBride, K., Hunt, H., Jones, T., Cherry, S.R., Badawi, R.D. (2024). Practical Considerations for Total-Body PET Acquisition and Imaging. In: Witney, T.H., Shuhendler, A.J. (eds) Positron Emission Tomography. Methods in Molecular Biology, vol 2729. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3499-8_21

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  • DOI: https://doi.org/10.1007/978-1-0716-3499-8_21

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3498-1

  • Online ISBN: 978-1-0716-3499-8

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