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Hubs and Bottlenecks in Protein-Protein Interaction Networks

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Reverse Engineering of Regulatory Networks

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2719))

Abstract

Protein-protein interaction networks (PPINs) represent the physical interactions among proteins in a cell. These interactions are critical in all cellular processes, including signal transduction, metabolic regulation, and gene expression. In PPINs, centrality measures are widely used to identify the most critical nodes. The two most commonly used centrality measures in networks are degree and betweenness centralities. Degree centrality is the number of connections a node has in the network, and betweenness centrality is the measure of the extent to which a node lies on the shortest paths between pairs of other nodes in the network. In PPINs, proteins with high degree and betweenness centrality are referred to as hubs and bottlenecks respectively. Hubs and bottlenecks are topologically and functionally essential proteins that play crucial roles in maintaining the network’s structure and function. This article comprehensively reviews essential literature on hubs and bottlenecks, including their properties and functions.

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Acknowledgments

N.C., a registered PhD student at the University of Hyderabad, gratefully acknowledges the Boarding cum Lodging (BBL) fellowship from the University of Hyderabad. H.A.N. gratefully acknowledges the core grant support from the University of Hyderabad. All the authors gratefully acknowledge the SAHAJ-BUILDER support.

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Authors and Affiliations

  1. Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India

    Chandramohan Nithya

  2. Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India

    Manjari Kiran & Hampapathalu Adimurthy Nagarajaram

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  1. Chandramohan Nithya
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  2. Manjari Kiran
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  3. Hampapathalu Adimurthy Nagarajaram
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Correspondence to Hampapathalu Adimurthy Nagarajaram .

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Editors and Affiliations

  1. Department of Electronics and Communication Engineering, Jalpaiguri Govt. Engineering College, Jalpaiguri, West Bengal, India

    Sudip Mandal

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Nithya, C., Kiran, M., Nagarajaram, H.A. (2024). Hubs and Bottlenecks in Protein-Protein Interaction Networks. In: Mandal, S. (eds) Reverse Engineering of Regulatory Networks. Methods in Molecular Biology, vol 2719. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3461-5_13

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  • DOI: https://doi.org/10.1007/978-1-0716-3461-5_13

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