Abstract
Lactobacilli-derived postbiotics contain a diverse set of molecules, including peptidoglycan, surface proteins, cell wall polysaccharides, secreted proteins, bacteriocin, and organic acids, all of which have beneficial effects on the host, such as immunomodulatory, antitumor, antimicrobial, and barrier-preservation effects. In this chapter, we comprehensively summarize the immunomodulatory methods of Lactobacilli-derived postbiotics. Immunomodulatory methods are measured by analyzing cytokines production with human intestinal epithelial cell (IECs) and human dendritic cells (DCs).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Malashree L, Angadi V, Yadav S, Prabha R (2019) “Postbiotics”—one step ahead of probiotics. Int J Curr Microbiol Appl Sci 8:2049–2053
Collado MC, Vinderola G, Salminen S (2019) Postbiotics: facts and open questions. A position paper on the need for a consensus definition. Benef Microbes 10:711–719
Kolling Y, Salva S, Villena J, Marranzino G, Alvarez S (2015) Non-viable immunobiotic Lactobacillus rhamnosusCRL1505 and its peptidoglycan improve systemic and respiratory innate immune response during recovery of immunocompromised-malnourished mice. Int Immunopharmacol 25:474–484. https://doi.org/10.1016/j.intimp.2015.02.006
Shida K, Kiyoshima-Shibata J, Kaji R, Nagaoka M, Nanno M (2009) Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms. Immunology 128:e858–e869. https://doi.org/10.1111/j.1365-2567.2009.03095.x
Font GM, Martos GI (2005) Lactic acid bacteria diversity: preservation ex situ of native argentinian strains. Agrociencia 9:431–434. http://hdl.handle.net/11336/74657
Shida K, Kiyoshima-Shibata J, Kaji R, Nagaoka M, M. (2009) Nanno, peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms. Immunology 128:e858–e869. https://doi.org/10.1111/j.1365-2567.2009.03095.x
Jaffer U, Wade RG, Gourlay T (2010) Cytokines in the systemic inflammatory response syndrome: a review. HSR Proc Intensive CareCardiovasc Anesth 2:161–175
Neurath MF (2014) Cytokines in inflammatory bowel disease. Nat Rev Immunol 14:329–342
Khokhlova EV, Smeianov VV, Efimov BA, Kafarskaia LI, Pavlova SI, Shkoporov AN (2012) Anti-inflammatory properties of intestinal Bifidobacterium strains isolated from healthy infants. Microbiol Immunol 56:27–39
Silva A, Silva T, Nicoli J, Vasquez-Pinto L, Martins F (2014) In vitro evaluation of antagonism, modulation of cytokines and extracellular matrix proteins by Bifidobacterium strains. Lett Appl Microbiol 67:497–505
Mastropietro I, Tiscornia K, Perelmuter S, Astrada M (2015) Bollati-Fogolín, HT-29 and Caco-2 reporter cell lines for functional studies of nuclear factor kappa B activation. Mediat Inflamm 2015:860534. https://doi.org/10.1155/2015/860534
Tiscornia I, S’anchez-Martins V, Hern’andez A, Bollati-Fogolín M (2012) Human monocyte-derived dendritic cells from leukoreduction system chambers after plateletpheresis are functional in an in vitro co-culture assay with intestinal epithelial cells. J Immunol Methods 384:164–170. https://doi.org/10.1016/j.jim.2012.07.005
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
About this chapter
Cite this chapter
Arasu, K.A., Rajasekar, T. (2024). Immunomodulatory Activity of Postbiotics from Lactobacillus. In: Dharumadurai, D. (eds) Postbiotics. Methods and Protocols in Food Science . Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3421-9_25
Download citation
DOI: https://doi.org/10.1007/978-1-0716-3421-9_25
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-3420-2
Online ISBN: 978-1-0716-3421-9
eBook Packages: Springer Protocols