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Role of Heat Shock Factors in Stress-Induced Transcription: An Update

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Chaperones

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2693))

Abstract

Heat shock proteins (HSP) are rapidly induced after proteotoxic stresses such as heat shock and accumulate at high concentrations in cells. HSP induction involves primarily a family of heat shock transcription factors (HSF) that bind the heat shock elements of the HSP genes and mediate transcription in trans. We discuss methods for the study of HSP binding to HSP promoters and the consequent increases in HSP gene expression in vitro and in vivo.

This work was supported by NIH research grants RO-1CA047407, R01CA119045 and RO-1CA094397.

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Author information

Authors and Affiliations

  1. Department of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea

    Heyoun Bunch

  2. Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Stuart K. Calderwood

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  1. Heyoun Bunch
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  2. Stuart K. Calderwood
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Corresponding author

Correspondence to Stuart K. Calderwood .

Editor information

Editors and Affiliations

  1. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Stuart K. Calderwood

  2. Danville, PA, USA

    Thomas L. Prince

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Bunch, H., Calderwood, S.K. (2023). Role of Heat Shock Factors in Stress-Induced Transcription: An Update. In: Calderwood, S.K., Prince, T.L. (eds) Chaperones. Methods in Molecular Biology, vol 2693. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3342-7_3

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  • DOI: https://doi.org/10.1007/978-1-0716-3342-7_3

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3341-0

  • Online ISBN: 978-1-0716-3342-7

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