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Pavlovian Spontaneous Recovery as a Measure of Alcohol-Seeking Behavior

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Translational Research Methods for Alcohol Use Disorders

Part of the book series: Neuromethods ((NM,volume 201))

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Abstract

Alcohol (EtOH) addiction can be characterized as a chronic relapsing disorder. EtOH craving is a critical precipitating factor to relapse. Environmental and conditioning cues can elicit drug-seeking ‘craving’ in both humans and rodents. The operant Pavlovian Spontaneous Recovery (PSR) model of EtOH-seeking is a unique and suitable model for studying ‘craving-like’ behavior as well as examining underlying neural systems and mechanisms that may be involved in ‘craving-like’ and, by extension, relapse behavior in rodents. Our objective is to provide the reader with details and methods on the benefits of using the PSR model to examine and better understand EtOH ‘craving-like’ behavior.

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Acknowledgements

Preparation of this manuscript and its associated experiments were supported in part by AA020908 (ZAR), AA013522 (RLB), AA022287, AA007611, AA007462, and AA010721. The views expressed in this manuscript do not necessarily represent those of the National Institutes of Health (NIH) or the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The products mentioned in this manuscript do not represent an endorsement of the particular manufacturer, but only reflect the products used by our laboratories. All authors claim no perceived or real conflicts of interest.

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Authors and Affiliations

  1. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA

    Sheketha R. Hauser, Richard L. Bell & Zachary A. Rodd

  2. Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA

    Sheketha R. Hauser, Richard L. Bell & Zachary A. Rodd

Authors
  1. Sheketha R. Hauser
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  2. Richard L. Bell
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  3. Zachary A. Rodd
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Correspondence to Sheketha R. Hauser .

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  1. Department of Psychology, Indiana University – Purdue University, Indianapolis, IN, USA

    Melissa A. Cyders

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Hauser, S.R., Bell, R.L., Rodd, Z.A. (2023). Pavlovian Spontaneous Recovery as a Measure of Alcohol-Seeking Behavior. In: Cyders, M.A. (eds) Translational Research Methods for Alcohol Use Disorders. Neuromethods, vol 201. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3267-3_2

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  • DOI: https://doi.org/10.1007/978-1-0716-3267-3_2

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