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Platelet-Rich Plasma for Intra-articular Injections: Preclinical and Clinical Evidence

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Cartilage Tissue Engineering

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2598))

Abstract

The use of platelet-rich plasma (PRP) has been supported by encouraging data from in vitro and preclinical in vivo studies, both in terms of safety and efficacy. This led to the wide use of PRP injections in the clinical practice, with promising results especially as a minimally invasive treatment for cartilage degeneration and osteoarthritis (OA). While many controversies remain on the best PRP formulation, the overall available clinical studies support the benefits of PRP, with functional improvement and reduction of pain-related symptoms up to 12 months, especially in young patients and early OA stages.

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Author information

Authors and Affiliations

  1. Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Angelo Boffa & Giuseppe Filardo

  2. Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

    Giuseppe Filardo

  3. Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

    Giuseppe Filardo

Authors
  1. Angelo Boffa
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  2. Giuseppe Filardo
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Correspondence to Angelo Boffa .

Editor information

Editors and Affiliations

  1. AO Research Institute Davos, Davos Platz, Switzerland

    Martin J. Stoddart

  2. AO Research Institute Davos, Davos Platz, Switzerland

    Elena Della Bella

  3. UCB Pharma, Slough, UK

    Angela R. Armiento

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Boffa, A., Filardo, G. (2023). Platelet-Rich Plasma for Intra-articular Injections: Preclinical and Clinical Evidence. In: Stoddart, M.J., Della Bella, E., Armiento, A.R. (eds) Cartilage Tissue Engineering. Methods in Molecular Biology, vol 2598. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2839-3_28

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  • DOI: https://doi.org/10.1007/978-1-0716-2839-3_28

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2838-6

  • Online ISBN: 978-1-0716-2839-3

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