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Alternative In Vivo Models to Study Teratoma

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Tumor Angiogenesis Assays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2572))

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Abstract

Embryonic stem cells give rise to teratomas when injected in vivo in experimental animal models. The characterization, the manipulation, and the breaking off of this specific characteristic are doubtlessly the last frontier for the applications of stem cells in translational medicine. Moreover, the urgency to adapt to new scientific demands drives the researcher to find alternative and faster models for testing the teratogenic properties of embryonic stem cells. Here, we compare the emerging model of the chick embryo chorioallantoic membrane (CAM) to the murine model, which represents the gold standard procedure for teratogenesis.

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Acknowledgments

This work was supported by grants from Fondazione Italiana per la Ricerca sul Cancro (AIRC) to S.M. (IG 2021 Id 25726) and AIRC Fellowship for Italy 2021 to M.C. (Project Code 26917). In addition, the authors are grateful to Prof. Marco Presta, Prof. Patrizia Dell’Era, and Prof. Roberto Ronca for the scientific discussion.

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Authors and Affiliations

  1. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

    Michela Corsini & Stefania Mitola

Authors
  1. Michela Corsini
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  2. Stefania Mitola
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Correspondence to Stefania Mitola .

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Editors and Affiliations

  1. Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

    Domenico Ribatti

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Corsini, M., Mitola, S. (2023). Alternative In Vivo Models to Study Teratoma. In: Ribatti, D. (eds) Tumor Angiogenesis Assays. Methods in Molecular Biology, vol 2572. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2703-7_14

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  • DOI: https://doi.org/10.1007/978-1-0716-2703-7_14

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2702-0

  • Online ISBN: 978-1-0716-2703-7

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