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Alternative Ligands at Melatonin Receptors

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Melatonin

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2550))

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Abstract

Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that possesses a wide range of biological effects. Most of the main recognized effects of this hormone in mammals are due to its interaction with two G protein-coupled receptors, MT1 and MT2. Ligand-binding studies have been based on the use of its radioligand analog, 2[125I]-iodomelatonin, a super agonist discovered in the early 1990s. This compound has been used in most of the binding studies reported in the literature. Nevertheless, more recently other possibilities arose. This chapter is a brief summary of those alternative radioligands and of their benefits one can find in using them.

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Author information

Authors and Affiliations

  1. Pole d’expertise Biotechnologie, Chimie & Biologie, Institut de Recherches Servier, Croissy-sur-Seine, France

    Céline Legros & Jean A. Boutin

  2. Eurofins Discovery, Celle l’Evescault, France

    Céline Legros

  3. UMR-S 1172-LiNC-Lille Neuroscience & Cognition, Lille, France

    Said Yous

  4. PHARMADEV (Pharmacochimie et biologie pour le développement), Faculté de Pharmacie, Toulouse, France

    Jean A. Boutin

Authors
  1. Céline Legros
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  2. Said Yous
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  3. Jean A. Boutin
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Editor information

Editors and Affiliations

  1. Inserm, U1016, Institut Cochin, PARIS, France

    Ralf Jockers

  2. Inserm, U1016, Institut Cochin, PARIS, France

    Erika Cecon

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© 2022 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Legros, C., Yous, S., Boutin, J.A. (2022). Alternative Ligands at Melatonin Receptors. In: Jockers, R., Cecon, E. (eds) Melatonin. Methods in Molecular Biology, vol 2550. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2593-4_19

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  • DOI: https://doi.org/10.1007/978-1-0716-2593-4_19

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2592-7

  • Online ISBN: 978-1-0716-2593-4

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