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General Considerations for In Vivo Exploration of Synaptic Plasticity

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Electrophysiological Analysis of Synaptic Transmission

Part of the book series: Neuromethods ((NM,volume 187))

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Abstract

Studying synaptic plasticity in a neuron’s in vivo milieu has unparalleled physiological relevance and translational values. Although in vivo and ex vivo recordings share many basic principles as this book has discussed so far, some special considerations must be taken in the experimental design process for in vivo experiments. In this chapter, we will discuss unique advantages of in vivo recording as well as their technical challenges. Furthermore, we will discuss the principles of selecting appropriate recording configurations based on specific experimental variables. We expect at the end of this chapter that the readers will learn to determine whether in vivo preparations are necessary or suitable for the research questions of interest.

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Author information

Author notes

  1. Xiyu Zhu

    Present address: University of California San Francisco, San Francisco, CA, USA

Authors and Affiliations

  1. University of Pittsburgh, Pittsburgh, PA, USA

    Xiyu Zhu & Anthony A. Grace

Authors
  1. Xiyu Zhu
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  2. Anthony A. Grace
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Corresponding authors

Correspondence to Xiyu Zhu or Anthony A. Grace .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, The Pennsylvania State University, Hershey, PA, USA

    Nicholas Graziane

  2. Neuroscience Department, University of Pittsburgh, Pittsburgh, PA, USA

    Yan Dong

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© 2022 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Zhu, X., Grace, A.A. (2022). General Considerations for In Vivo Exploration of Synaptic Plasticity. In: Graziane, N., Dong, Y. (eds) Electrophysiological Analysis of Synaptic Transmission. Neuromethods, vol 187. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2589-7_23

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  • DOI: https://doi.org/10.1007/978-1-0716-2589-7_23

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2588-0

  • Online ISBN: 978-1-0716-2589-7

  • eBook Packages: Springer Protocols

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