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Vasculogenic Mimicry—An Overview

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Vasculogenic Mimicry

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2514))

Abstract

Vasculogenic mimicry (VM), a tumor microcirculation model found in melanoma in the last 20 years, is a vascular channel-like structure composed of tumor cells, but without endothelial cells, that stains positive for periodic acid-Schiff (PAS) and negative staining for CD31. VM provides, to the highly aggressive malignant tumor cells, adequate oxygen and nutrient supply for tumor growth and subsequent metastasis process and its presence are related to poor prognosis in patients. VM is independent of endothelial cells, which may partly explain why angiogenesis drug inhibitors have not achieved the expected success for cancer treatment.

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Authors and Affiliations

  1. Chemical and Food Engineering Department, Federal University of Santa Catarina, Florianópolis, SC, Brazil

    Emily Marques dos Reis & Fernanda Vieira Berti

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  1. Emily Marques dos Reis
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  2. Fernanda Vieira Berti
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  1. InteLab/EQA, Federal Institute of Santa Catarina, Florianopolis, Brazil

    Emily Marques dos Reis

  2. Human Cell and Tissue Engineering, Biocelltis Bioengineering, Florianopolis, Brazil

    Fernanda Berti

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Marques dos Reis, E., Vieira Berti, F. (2022). Vasculogenic Mimicry—An Overview. In: Marques dos Reis, E., Berti, F. (eds) Vasculogenic Mimicry. Methods in Molecular Biology, vol 2514. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2403-6_1

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