Abstract
Strictosidine is the common biosynthetic precursor of Monoterpene Indole Alkaloids (MIA). A practical single-step procedure to assemble strictosidine from secologanin is described via a bioinspired Pictet–Spengler reaction. Mild conditions and purification by crystallization and flash chromatography allow access to the targeted product in fair yield.
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University Paris-Saclay is acknowledged for financial support.
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Dou, Y., Evanno, L., Poupon, E., Vincent, G. (2022). Pictet–Spengler Reaction for the Chemical Synthesis of Strictosidine. In: Courdavault, V., Besseau, S. (eds) Catharanthus roseus. Methods in Molecular Biology, vol 2505. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2349-7_6
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DOI: https://doi.org/10.1007/978-1-0716-2349-7_6
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