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Connectome-Based Lesion-Symptom Mapping Using Structural Brain Imaging

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Lesion-to-Symptom Mapping

Part of the book series: Neuromethods ((NM,volume 180))

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Abstract

Lesion-symptom mapping has been fundamental in furthering our understanding of the neurobiological basis of behavior and cognition. Since its inception, voxel-based approaches have helped establish the relationship between brain gray matter structures and behavioral function in an objective and quantifiable way. However, brain damage can extend well beyond the area of apparent gray matter injury, and functional deficits may also result from changes to the white matter tracts that provide the scaffolding for brain function. In this chapter, we discuss how connectome-based lesion-symptom mapping (CLSM) can help determine a statistical relationship between the strength of connections between brain regions across the brain and the wide variety of behavioral deficits seen in patients with different types of brain injury. We propose that CLSM can therefore provide valuable complementary information based on lesion-symptom mapping that is less constrained by cortical injury.

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Authors and Affiliations

  1. Department of Neurology, Medical University of South Carolina, Charleston, SC, USA

    Ezequiel Gleichgerrcht, Janina Wilmskoetter & Leonardo Bonilha

Authors
  1. Ezequiel Gleichgerrcht
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  2. Janina Wilmskoetter
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  3. Leonardo Bonilha
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Editors and Affiliations

  1. Experimental Neuroimaging, CHDI Management/CHDI Foundation, Princeton, NJ, USA

    Dorian Pustina

  2. Department of Psychology, University of Edinburgh, Edinburgh, UK

    Daniel Mirman

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Gleichgerrcht, E., Wilmskoetter, J., Bonilha, L. (2022). Connectome-Based Lesion-Symptom Mapping Using Structural Brain Imaging. In: Pustina, D., Mirman, D. (eds) Lesion-to-Symptom Mapping. Neuromethods, vol 180. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-2225-4_9

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  • DOI: https://doi.org/10.1007/978-1-0716-2225-4_9

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