Skip to main content
SpringerLink
Log in

Combination of Photodynamic Therapy and Therapeutic Vaccination

  • Protocol
  • First Online:
Photodynamic Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2451))

  • 1082 Accesses

Abstract

Tumor ablation by photodynamic therapy (PDT) results in a strong reduction in tumor mass and can lead to improved recognition of tumor cells by the immune system. This supports combinations of PDT and immunotherapy for the treatment of advanced tumors. Therapeutic vaccination is a tumor-specific type of cancer immunotherapy that aims to directly strengthen the immune response against tumor antigens. In this chapter, we describe the combination of PDT and therapeutic vaccination using a peptide tumor antigen vaccine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Korbelik M (2011) Cancer vaccines generated by photodynamic therapy. Photochem Photobiol Sci 10:664–669

    Article  CAS  PubMed  Google Scholar 

  2. Melief CJM, Van Hall T, Arens R et al (2015) Therapeutic cancer vaccines. J Clin Invest 125:3401–3412

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kenter GG, Welters MJP, Valentijn ARPM et al (2009) Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med 361:1838–1847. https://doi.org/10.1056/NEJMoa0810097

    Article  CAS  PubMed  Google Scholar 

  4. Kenter GG, Welters MJP, Valentijn ARPM et al (2008) Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity. Clin Cancer Res 14:169–177. https://doi.org/10.1158/1078-0432.CCR-07-1881

    Article  CAS  PubMed  Google Scholar 

  5. van Poelgeest MIE, Welters MJP, van Esch EMG et al (2013) HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial. J Transl Med 11:88. https://doi.org/10.1186/1479-5876-11-88

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Kleinovink JW, Van Driel PB, Snoeks TJ et al (2016) Combination of photodynamic therapy and specific immunotherapy efficiently eradicates established tumors. Clin Cancer Res 22:1459–1468

    Article  CAS  PubMed  Google Scholar 

  7. Khong H, Overwijk WW (2016) Adjuvants for peptide-based cancer vaccines. J Immunother Cancer 4:56. https://doi.org/10.1186/s40425-016-0160-y

    Article  PubMed  PubMed Central  Google Scholar 

  8. Temizoz B, Kuroda E, Ishii KJ (2016) Vaccine adjuvants as potential cancer immunotherapeutics. Int Immunol 28:329–338. https://doi.org/10.1093/intimm/dxw015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lin KY, Guarnieri FG, Staveley-O’Carroll KF et al (1996) Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res 56:21–26

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, Tumor Immunology Group, Leiden University Medical Center, Leiden, The Netherlands

    Jan Willem Kleinovink & Ferry Ossendorp

Authors
  1. Jan Willem Kleinovink
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ferry Ossendorp
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ferry Ossendorp .

Editor information

Editors and Affiliations

  1. Institute for Advanced Biosciences, Université de Grenoble Alpes, Grenoble, France

    Mans Broekgaarden

  2. van ‘t Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands

    Hong Zhang

  3. British Columbia Cancer Research Centre, Vancouver, BC, Canada

    Mladen Korbelik

  4. Laser Research Centre, University of Johannesburg, Doornfontein, South Africa

    Michael R. Hamblin

  5. Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, Jiaxing University College of Medicine, Jiaxing, Zhejiang, China

    Michal Heger

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Science+Business Media, LLC, part of Springer Nature

About this protocol

Check for updates. Verify currency and authenticity via CrossMark

Cite this protocol

Kleinovink, J.W., Ossendorp, F. (2022). Combination of Photodynamic Therapy and Therapeutic Vaccination. In: Broekgaarden, M., Zhang, H., Korbelik, M., Hamblin, M.R., Heger, M. (eds) Photodynamic Therapy. Methods in Molecular Biology, vol 2451. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2099-1_31

Download citation

  • DOI: https://doi.org/10.1007/978-1-0716-2099-1_31

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2098-4

  • Online ISBN: 978-1-0716-2099-1

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Search

Navigation