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Optogenetic Animal Models of Depression: From Mice to Men

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Translational Research Methods for Major Depressive Disorder

Part of the book series: Neuromethods ((NM,volume 179))

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Abstract

Optogenetics, the light-induced reversible control of specific neuronal ensembles, has revolutionized the circuit level analysis of depression, leading to the identification of relevant circuitries in several brain regions including—but not limited to—medial prefrontal cortex, ventral tegmental area, and nucleus accumbens in rodents. While it is still early to observe a direct translational utility, the continuous progress in optogenetic interrogation of specific neural populations has great potential for untangling the complex pathophysiology of depression.

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Notes

  1. 1.

    https://www.who.int/news-room/fact-sheets/detail/depression retrieved in 03.04.2021

Abbreviations

5-HT:

5-Hydroxytryptamine

AAVs:

Adeno-associated viruses

ACC:

Anterior cingulate cortex

AD:

Antidepressant

AMY:

Amygdala

avBNST:

Anteroventral bed nuclei of the stria terminalis

BDNF:

Brain-derived neurotrophic factor

BLA:

Basolateral amygdala

BMA:

Basomedial amygdala

BNST:

Bed nucleus of the stria terminalis

CaMKIIa:

Ca2+/calmodulin-dependent protein kinase II

CCK:

Cholecystokinin

CCK-B:

Cholecystokinin-B receptor

CeA:

Central amygdala

ChR2:

Channelrhodopsin-2

CMS:

Chronic mild stress

CRF:

Corticotropin-releasing factor

CSDS:

Chronic social defeat stress

D1:

Dopamine 1

D2:

Dopamine 2

DA:

Dopamine

DG:

Dentate gyrus

Drd1:

Dopamine receptor 1

Drd2:

Dopamine receptor 2

DRN:

Dorsal raphe nucleus

EPM:

Elevated plus maze

FST:

Forced swim test

GABA:

Gamma-aminobutyric acid

GABA(A)Rs:

Gamma-aminobutyric acid A receptors

GluClR:

Glutamate-gated chloride channel receptor

HPA system:

Hypothalamus-pituitary-adrenal system

IL-PFC:

Infralimbic prefrontal cortex

ILT:

Intralaminar thalamus

LHb:

Lateral habenula

MDT:

Medial dorsal thalamus

mHb:

Medial habenula

mPFC:

Medial prefrontal cortex

MSNs:

Medium spiny neurons

NAc:

Nucleus accumbens

NMDAR:

N-Methyl-D-aspartate receptor

NSF:

Novelty-suppressed feeding test

PIT:

Pavlovian-to-instrumental transfer

PR:

Progressive ratio

PrL:

Prelimbic area

PVH:

Paraventricular hypothalamus

RMTg:

Rostromedial tegmental nucleus

RN:

Raphe nucleus

SDS:

Social defeat stress

SPT:

Sucrose preference test

SSDS:

Subthreshold social defeat stress

TST:

Tail suspension test

vGlut:

Vesicular glutamate transporter 2

vHipp:

Ventral hippocampus

vlPAG:

Ventrolateral periaqueductal gray

vmPFC:

Ventral medial prefrontal cortex

VP:

Ventral pallidum

vSTR:

Ventral striatum

VTA:

Ventral tegmental area

ΔFosB:

DeltaFosB

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Authors and Affiliations

  1. School of Advanced Studies, University of Tyumen, Tyumen, Russia

    Ayla Arslan

  2. Department of Psychology, International University of Sarajevo, Sarajevo, Bosnia and Herzegovina

    Pinar Unal-Aydin & Orkun Aydin

  3. Unity Biotechnology, South San Francisco, CA, USA

    Taner Dogan

Authors
  1. Ayla Arslan
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  2. Pinar Unal-Aydin
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  3. Taner Dogan
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  4. Orkun Aydin
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Corresponding author

Correspondence to Ayla Arslan .

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Editors and Affiliations

  1. Department of Psychiatry, Korea University Ansan Hospital, Ansan, Korea (Republic of)

    Yong-Ku Kim

  2. Deptartment of Speech Therapy, Isfahan University of Medical Sciences, Isfahan, Iran

    Meysam Amidfar

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Arslan, A., Unal-Aydin, P., Dogan, T., Aydin, O. (2022). Optogenetic Animal Models of Depression: From Mice to Men. In: Kim, YK., Amidfar, M. (eds) Translational Research Methods for Major Depressive Disorder. Neuromethods, vol 179. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2083-0_8

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  • DOI: https://doi.org/10.1007/978-1-0716-2083-0_8

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