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Mapping Structure–Function Relationships within Cerebellar Circuits

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Measuring Cerebellar Function

Part of the book series: Neuromethods ((NM,volume 177))

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Abstract

A key organizational feature of the cerebellum is its division into a series of cerebellar modules. The cortical component of each module is termed a zone. Each zone is defined by its climbing input originating from a well-defined region of the inferior olive, which targets one or more longitudinal zones of Purkinje cells within the cerebellar cortex. In turn, Purkinje cells within each zone project to specific regions of the cerebellar and vestibular nuclei. The behavioral significance of zones remains poorly understood.

This chapter will describe approaches to physiologically and anatomically identify cerebellar cortical zones in both acute and chronic preparat ions (rat and cat) as well as methods to record from zones during behavior in order to determine the role that they have in cerebellar function.

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Authors and Affiliations

  1. School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK

    Richard Apps, Charlotte L. Lawrenson, Elena Paci & Nadia L. Cerminara

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  1. Richard Apps
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  2. Charlotte L. Lawrenson
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  3. Elena Paci
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  4. Nadia L. Cerminara
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Correspondence to Richard Apps or Nadia L. Cerminara .

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  1. Houston, TX, USA

    Roy V. Sillitoe

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Apps, R., Lawrenson, C.L., Paci, E., Cerminara, N.L. (2022). Mapping Structure–Function Relationships within Cerebellar Circuits. In: Sillitoe, R.V. (eds) Measuring Cerebellar Function. Neuromethods, vol 177. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2026-7_4

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  • DOI: https://doi.org/10.1007/978-1-0716-2026-7_4

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