Abstract
The immune system plays a key role in cancer prevention, initiation, and progression. Antitumoral immune responses can be boosted by harnessing antitumorigenic immune activators and/or blocking tumorigenic proinflammatory factors. Here we define these targets as well as the strategies that could be developed for effective cancer immunoprevention.
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References
Singh SK, Dorak MT (2017) Cancer immunoprevention and public health. Front Public Health 5:101
Smit MA, Jaffee EM, Lutz ER (2014) Cancer immunoprevention—the next frontier. Cancer Prev Res 7(11):1072–1080
Beatty GL, Gladney WL (2015) Immune escape mechanisms as a guide for cancer immunotherapy. Clin Cancer Res 21(4):687–692
Tanaka T, Narazaki M, Kishimoto T (2014) IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 6(10):a016295
El-Osta HE, Kurzrock R (2011) Castleman’s disease: from basic mechanisms to molecular therapeutics. Oncologist 16(4):497–511
Rider P, Carmi Y, Cohen I (2016) Biologics for targeting inflammatory cytokines, clinical uses, and limitations. Int J Cell Biol 2016:9259646
Garlanda C, Dinarello CA, Mantovani A (2013) The interleukin-1 family: back to the future. Immunity 39(6):1003–1018
Mantovani A, Barajon I, Garlanda C (2018) IL-1 and IL-1 regulatory pathways in cancer progression and therapy. Immunol Rev 281(1):57–61
Alfaro C et al (2017) Interleukin-8 in cancer pathogenesis, treatment and follow-up. Cancer Treat Rev 60:24–31
David JM et al (2016) The IL-8/IL-8R axis: a double agent in tumor immune resistance. Vaccines 4(3)
Gales D et al (2013) The chemokine CXCL8 in carcinogenesis and drug response. ISRN Oncol 2013:859154
Roeser J, Leach S, McAllister F (2015) Emerging strategies for cancer immunoprevention. Oncogene 34(50):6029
Huang RR et al (2011) CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans. Clin Cancer Res 17(12):4101–4109
Hodi FS et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711–723
Bengsch F et al (2017) CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer. Cancer Immunol Immunother 66(12):1609–1617
Vargas FA et al (2018) Fc effector function contributes to the activity of human anti-CTLA-4 antibodies. Cancer Cell 33(4):649–663.e4
Snyder A et al (2014) Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 371(23):2189–2199
Prasad V, Kaestner V (2017) Nivolumab and pembrolizumab: monoclonal antibodies against programmed cell death-1 (PD-1) that are interchangeable. In: Seminars in oncology. Elsevier
Zhang J, Wolfgang C, Zheng L (2018) Precision immuno-oncology: prospects of individualized immunotherapy for pancreatic cancer. Cancers 10(2):39
Soares KC et al (2015) PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors. J Immunother 38(1):1
Burr ML et al (2017) CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 549(7670):101
Mezzadra R et al (2017) Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature 549(7670):106
Takamori S et al (2018) Differences in PD-L1 expression on tumor and immune cells between lung metastases and corresponding primary tumors. Surg Oncol 27(4):637–641
Mansfield A et al (2016) Temporal and spatial discordance of programmed cell death-ligand 1 expression and lymphocyte tumor infiltration between paired primary lesions and brain metastases in lung cancer. Ann Oncol 27(10):1953–1958
Marshall EA et al (2016) Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis. Mol Cancer 15(1):67
Luo C, Zhang H (2017) The role of proinflammatory pathways in the pathogenesis of colitis-associated colorectal cancer. Mediat Inflamm 2017:5126048
Joerger M et al (2016) The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy? Expert Opin Ther Targets 20(11):1339–1356
McAllister F et al (2014) Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell 25(5):621–637
Fabre J et al (2016) Targeting the tumor microenvironment: the protumor effects of IL-17 related to cancer type. Int J Mol Sci 17(9)
Yuan J, Zhang F, Niu R (2015) Multiple regulation pathways and pivotal biological functions of STAT3 in cancer. Sci Rep 5:17663
Chai EZ et al (2016) Targeting transcription factor STAT3 for cancer prevention and therapy. Pharmacol Ther 162:86–97
Sen M et al (2012) First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov 2(8):694–705
Ward-Hartstonge KA, Kemp RA (2017) Regulatory T-cell heterogeneity and the cancer immune response. Clin Transl Immunol 6(9):e154
Tanaka A, Sakaguchi S (2017) Regulatory T cells in cancer immunotherapy. Cell Res 27(1):109–118
Sieow JL, Gun SY, Wong SC (2018) The sweet surrender: how myeloid cell metabolic plasticity shapes the tumor microenvironment. Front Cell Dev Biol 6:168
Bruchard M et al (2013) Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med 19(1):57
de Coana YP et al (2017) Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma. Oncotarget 8(13):21539
Ibáñez-Vea M et al (2018) Myeloid-derived suppressor cells in the tumor microenvironment: current knowledge and future perspectives. Arch Immunol Ther Exp 66(2):113–123
Treffers LW et al (2016) Neutrophils in cancer. Immunol Rev 273(1):312–328
Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122(3):787–795
Tremble LF, Forde PF, Soden DM (2017) Clinical evaluation of macrophages in cancer: role in treatment, modulation and challenges. Cancer Immunol Immunother 66(12):1509–1527
Vesely MD et al (2011) Natural innate and adaptive immunity to cancer. Annu Rev Immunol 29:235–271
Nair S, Dhodapkar MV (2017) Natural killer T cells in cancer immunotherapy. Front Immunol 8:1178
Böttcher JP et al (2018) NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell 172(5):1022–1037.e14
Parekh VV et al (2009) PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J Immunol 182(5):2816–2826
Koido S et al (2009) Cancer vaccine by fusions of dendritic and cancer cells. Clin Dev Immunol 2009:657369
Kumar C et al (2017) Immune modulation by dendritic-cell-based cancer vaccines. J Biosci 42(1):161–173
Yu P, Fu YX (2006) Tumor-infiltrating T lymphocytes: friends or foes? Lab Investig 86(3):231–245
Restifo NP, Dudley ME, Rosenberg SA (2012) Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 12(4):269–281
Wojtowicz ME, Dunn BK, Umar A (2016) Immunologic approaches to cancer prevention-current status, challenges, and future perspectives. Semin Oncol 43(1):161–172
Chu NJ, Armstrong TD, Jaffee EM (2015) Nonviral oncogenic antigens and the inflammatory signals driving early cancer development as targets for cancer immunoprevention. Clin Cancer Res 21(7):1549–1557
Lollini PL, De Giovanni C, Nanni P (2013) Preclinical HER-2 Vaccines: from Rodent to Human HER-2. Front Oncol 3:151
Kimura T et al (2013) MUC1 vaccine for individuals with advanced adenoma of the colon: a cancer immunoprevention feasibility study. Cancer Prev Res (Phila) 6(1):18–26
Castle JC et al (2012) Exploiting the mutanome for tumor vaccination. Cancer Res 72(5):1081–1091
Gubin MM et al (2014) Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515(7528):577–581
Ott PA et al (2017) An immunogenic personal neoantigen vaccine for patients with melanoma. Nature 547(7662):217–221
Umar A (2014) Cancer immunoprevention: a new approach to intercept cancer early. Cancer Prev Res 7(11):1067–1071
Pan J et al (2017) Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine. Oncotarget 8(47):82689–82699
Nasti TH et al (2015) Immunoprevention of chemical carcinogenesis through early recognition of oncogene mutations. J Immunol 194(6):2683–2695
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Unver, N., Mohindroo, C. (2022). Targets and Strategies for Cancer Immunoprevention. In: McAllister, F. (eds) Cancer Immunoprevention. Methods in Molecular Biology, vol 2435. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2014-4_2
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DOI: https://doi.org/10.1007/978-1-0716-2014-4_2
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Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-2013-7
Online ISBN: 978-1-0716-2014-4
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