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Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN)

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Biomedical Engineering Technologies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2394))

Abstract

The blood–brain barrier (BBB) is the major barrier for brain drug delivery and limits the treatment options for central nervous system diseases. To circumvent the BBB, we introduced the focused ultrasound-mediated intranasal brain drug delivery (FUSIN) technique. FUSIN utilizes the nasal route for direct nose-to-brain drug administration, bypassing the BBB and minimizing systemic exposure. It also uses the transcranial application of ultrasound energy focused at a targeted brain region to induce microbubble cavitation, which enhances the transport of intranasally administered agents at the FUS-targeted brain location. FUSIN is unique in that it can achieve noninvasive and localized brain drug delivery with minimized systemic toxicity. The goal of this chapter is to provide a detailed protocol for FUSIN delivery to the mouse brain.

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Acknowledgments

This work was in part supported by the National Institutes of Health (NIH) grant R01MH116981 and R01EB027223.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, USA

    Dezhuang Ye & Hong Chen

  2. Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA

    Hong Chen

Authors
  1. Dezhuang Ye
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  2. Hong Chen
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Corresponding author

Correspondence to Hong Chen .

Editor information

Editors and Affiliations

  1. Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA

    Avraham Rasooly

  2. Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA

    Houston Baker

  3. Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD, USA

    Miguel R. Ossandon

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© 2022 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Ye, D., Chen, H. (2022). Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN). In: Rasooly, A., Baker, H., Ossandon, M.R. (eds) Biomedical Engineering Technologies. Methods in Molecular Biology, vol 2394. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1811-0_26

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  • DOI: https://doi.org/10.1007/978-1-0716-1811-0_26

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1810-3

  • Online ISBN: 978-1-0716-1811-0

  • eBook Packages: Springer Protocols

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