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Molecular Imaging of Cerebrovascular Reactivity

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Cerebrovascular Reactivity

Part of the book series: Neuromethods ((NM,volume 175))

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Abstract

Positron emission tomography (PET) with [15O]H2O is the clinical reference standard for assessment of cerebrovascular reactivity (CVR). This molecular imaging technique measures the brain’s uptake of an exogenous, radioactive tracer and fits kinetic models to these measurements to quantify perfusion at rest and after a vasoactive challenge. Single-photon emission computed tomography (SPECT) with [99mTc]-labelled perfusion agents provides relative (non-quantitative) regional cerebral blood flow (rCBF). This chapter describes the theory, acquisition, and modelling aspects of nuclear medicine methods to measure CVR, with focus on [15O]H2O PET. The reliability of the CVR imaging biomarkers and their ability to identify hemodynamic impairment in neurovascular disorders are described. We also discuss the advantages and limitations of the approach and highlight technical advances including hybrid imaging with simultaneous PET/MRI to improve the accuracy and reduce the invasiveness of the methods.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA

    Audrey P. Fan

  2. Department of Neurology, University of California, Davis, Davis, CA, USA

    Audrey P. Fan

  3. Department of Clinical Physiology and Nuclear Medicine, Zeeland University Hospital, Køge, Denmark

    Oriol Puig Calvo

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  1. Audrey P. Fan
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  2. Oriol Puig Calvo
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Correspondence to Audrey P. Fan .

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Editors and Affiliations

  1. Baycrest Centre for Geriatric Care, University of Toronto, Toronto, ON, Canada

    Jean Chen

  2. Department of Neurosurgery, University Hospital Zurich, Zürich, Zürich, Switzerland

    Jorn Fierstra

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Fan, A.P., Puig Calvo, O. (2022). Molecular Imaging of Cerebrovascular Reactivity. In: Chen, J., Fierstra, J. (eds) Cerebrovascular Reactivity. Neuromethods, vol 175. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1763-2_3

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  • DOI: https://doi.org/10.1007/978-1-0716-1763-2_3

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