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Activation of Microglia and Macrophages in Neurodegenerative Diseases

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Neurodegenerative Diseases Biomarkers

Part of the book series: Neuromethods ((NM,volume 173))

Abstract

Activation of innate and adaptive immune responses represents a hallmark of neurological disorders. In addition to reactive brain-resident myeloid cells, recruitment of peripheral immune cells to the central nervous system (CNS) critically contributes to disease propagation in neuroinflammatory and neurodegenerative disorders. However, the role of different myeloid subpopulations remains controversial. Recent technological advances including the development of lineage tracing models and unbiased single cell screening approaches significantly contribute to our understanding of myeloid cell heterogeneity underlying lineage-specific disease-associated functions. Such insight provides critical knowledge for the development of myeloid cell–targeted therapies to combat neurological disorders.

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  1. Anna Salamero-Boix and Michael Schulz contributed equally with all other contributors.

Authors and Affiliations

  1. Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany

    Anna Salamero-Boix, Michael Schulz & Lisa Sevenich

  2. Biological Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany

    Anna Salamero-Boix & Michael Schulz

  3. German Cancer Consortium (DKTK, Partner Site Frankfurt/Mainz) and German Cancer Research Center (DKFZ), Heidelberg, Germany

    Lisa Sevenich

  4. Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany

    Lisa Sevenich

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  1. Anna Salamero-Boix
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  2. Michael Schulz
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  3. Lisa Sevenich
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Correspondence to Lisa Sevenich .

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Editors and Affiliations

  1. Department of Anatomy, University of Otago, Dunedin, New Zealand

    Philip V. Peplow

  2. Department of Pharmacology, Department of Medicine, Reno School of Medicine, University of Nevada, Reno, NV, USA

    Bridget Martinez

  3. Department of Neurosurgery, George Washington University, West Chester, PA, USA

    Thomas A. Gennarelli

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Salamero-Boix, A., Schulz, M., Sevenich, L. (2022). Activation of Microglia and Macrophages in Neurodegenerative Diseases . In: Peplow, P.V., Martinez, B., Gennarelli, T.A. (eds) Neurodegenerative Diseases Biomarkers. Neuromethods, vol 173. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1712-0_2

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