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PGK1 : An Essential Player in Modulating Tumor Metabolism

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Physical Exercise and Natural and Synthetic Products in Health and Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2343))

Abstract

Phosphoglycerate kinase 1 (PGK1) is the first enzyme in glycolysis to generate a molecule of ATP in the conversion of 1,3-bisphosphoglycerate (1,3-BPG) to 3-phosphoglycerate (3-PG). In addition to the role of glycolysis, PGK-1 acts as a polymerase alpha cofactor protein, with effects on the tricarboxylic acid cycle, DNA replication and repair. Posttranslational modifications such as methylation, phosphorylation, and acetylation have been seen to activate PGK1 in cancer. High levels of intracellular PGK1 are associated with tumorigenesis and progression, and chemoradiotherapy resistance. However, high levels of extracellular PGK1 suppress angiogenesis and subsequently counteract cancer malignancy. Here we have summarized the current knowledge on the mechanisms and effects of PGK1 in various tumor types and evaluated its potential prognostic and therapeutic value in cancer. The data summarized here aims at providing molecular information and new ideas of employing natural products to combat cancer associated with PGK1.

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Abbreviations

1,3-BPG:

1,3-Bisphosphoglycerate

3-PG:

3-Phosphoglycerate

ADP:

Adenosine diphosphate

AKT:

Protein kinase B

ATP:

Adenosine triphosphate

BECN1:

Beclin 1

CAF:

Cancer-activated fibroblasts

CXCL12:

Chemokine ligand 12

CXCR4:

Chemokine receptor 4

DNMT:

Maintenance DNA methyltransferase

EGCG :

Epigallocatechin gallate

ERK1/2:

Extracellular signal-regulated protein kinases 1 and 2

GDH:

Glutamate dehydrogenase

GLUT1:

Glucose transporter 1

GLUT2:

Glucose transporter 2

HDAC3:

Histone deacetylase 3

HIF-1α:

Hypoxia inducible factor 1-alpha

HKII:

Hexokinase II

KAT9:

Lysine acetyltransferase

LDH-A:

Lactate dehydrogenase-A

mTOR:

Mechanistic target of rapamycin

NSCLC:

Non-small-cell lung cancer

NSF:

Normal fibroblasts

O-GlcNAc:

O-linked N-acetylglucosamine

PCAF:

P300/CBP-associated factor

PDH:

Pyruvate dehydrogenase

PDHK1:

Pyruvate dehydrogenase kinase 2

PGK1 :

Phosphoglycerate kinase 1

Rab11FIP2:

RAB11 family-interacting protein 2

SAM:

S-adenosyl methionine

SIRT7:

Sirtuin 7

TCA:

Tricarboxylic acid cycle

TOM:

Translocase of the outer membrane

U2AF2:

U2 small nuclear RNA auxiliary factor

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Acknowledgments

This work was supported in part by NIH grants R01DE028351 and R03DE028387 and CURS Summer Scholars (to Y. Teng).

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Authors and Affiliations

  1. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA

    Leslie Duncan & Yong Teng

  2. Department of Pediatrics, Emory Children’s Center, Emory University, Atlanta, GA, USA

    Chloe Shay

  3. Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Yong Teng

  4. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA

    Yong Teng

Authors
  1. Leslie Duncan
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  2. Chloe Shay
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  3. Yong Teng
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Correspondence to Yong Teng .

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  1. Charlesworth House, Debden, Essex, UK

    Paul C. Guest

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Duncan, L., Shay, C., Teng, Y. (2022). PGK1 : An Essential Player in Modulating Tumor Metabolism. In: Guest, P.C. (eds) Physical Exercise and Natural and Synthetic Products in Health and Disease. Methods in Molecular Biology, vol 2343. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1558-4_4

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  • DOI: https://doi.org/10.1007/978-1-0716-1558-4_4

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1557-7

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