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The Use of Murine Infection Models to Investigate the Protective Role of TNF in Central Nervous System Tuberculosis

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The TNF Superfamily

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2248))

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Abstract

Tuberculosis of the central nervous system (CNS-TB) is the most severe form of extra-pulmonary tuberculosis that is often associated with high mortality. Secretion of tumor necrosis factor (TNF) has important protective and immune modulatory functions for immune responses during CNS-TB. Therefore, by combining the approaches of aerosol and intracerebral infection in mice, this chapter describes the methods to investigate the contribution of TNF in protective immunity against CNS-TB infection.

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Author information

Authors and Affiliations

  1. Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    Nai-Jen Hsu & Muazzam Jacobs

  2. National Health Laboratory Service, Johannesburg, South Africa

    Muazzam Jacobs

  3. Immunology of Infectious Disease Research Unit, University of Cape Town, Cape Town, South Africa

    Muazzam Jacobs

Authors
  1. Nai-Jen Hsu
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  2. Muazzam Jacobs
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Corresponding author

Correspondence to Muazzam Jacobs .

Editor information

Editors and Affiliations

  1. INSERM, Sorbonne Université, Paris, France

    Jagadeesh Bayry

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Hsu, NJ., Jacobs, M. (2021). The Use of Murine Infection Models to Investigate the Protective Role of TNF in Central Nervous System Tuberculosis. In: Bayry, J. (eds) The TNF Superfamily. Methods in Molecular Biology, vol 2248. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1130-2_15

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  • DOI: https://doi.org/10.1007/978-1-0716-1130-2_15

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1129-6

  • Online ISBN: 978-1-0716-1130-2

  • eBook Packages: Springer Protocols

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