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Drug Delivery Approaches and Imaging Techniques for Brain Tumor

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Nanotherapy for Brain Tumor Drug Delivery

Part of the book series: Neuromethods ((NM,volume 163))

Abstract

Brain tumor is an abnormal growth of tissue in the CNS that can interrupt the brain function and proved challenging to treat, largely owing to the biological characteristics which often conspire to limit progress. These tumors are located in one of the body’s most crucial organs and often beyond the reach due to BBB. The transport of substances across the BBB is strictly limited through both physical specialized connections (tight junctions) and metabolic barriers (enzymes and transport systems). Therefore, therapeutics have to pass through BBB before reaching the targeted sites in the brain tumor. This book chapter covered the types of brain tumors based on the diagnosis, strategies to improve the accumulation of anticancer drugs in the brain and brain tumor imaging. Numerous drug delivery approaches such as nanotechnology, focused ultrasound, hyperthermia, enhanced permeability and retention (EPR) effect, cell-penetrating peptides (CPP), ligand-mediated delivery, etc. have been discussed briefly to overcome the BBB and its advantages and limitations including other delivery system such as vaccines, stem cell therapy, etc. However, the main focus of this book chapter is on nanoparticle-based drug delivery system to overcome major obstacle in current brain cancer treatments. The different groups of nanoparticles that have been modified for brain tumor targeted drug delivery and brain targeted imaging have been discussed. Advances in these techniques suggest optimism for the future management of glioblastoma. Indeed, no single strategy is powerful enough to offer a substantial breakthrough for glioma treatment, so the future application of combined efforts and therapeutic agents might lead to a successful resolution.

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Author information

Authors and Affiliations

  1. Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA

    Mark Bell & Christine Pujol Rooks

  2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Science Center, Oklahoma City, OK, USA

    Vibhuti Agrahari

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  1. Mark Bell
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  2. Christine Pujol Rooks
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  3. Vibhuti Agrahari
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Correspondence to Vibhuti Agrahari .

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Editors and Affiliations

  1. CONRAD / Eastern Virginia Medical School, Arlington, VA, USA

    Vivek Agrahari

  2. Department of Neurosurgery and Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA

    Anthony Kim

  3. Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Science Center, Oklahoma City, OK, USA

    Vibhuti Agrahari

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Bell, M., Rooks, C.P., Agrahari, V. (2021). Drug Delivery Approaches and Imaging Techniques for Brain Tumor. In: Agrahari, V., Kim, A., Agrahari, V. (eds) Nanotherapy for Brain Tumor Drug Delivery. Neuromethods, vol 163. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1052-7_4

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  • DOI: https://doi.org/10.1007/978-1-0716-1052-7_4

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1051-0

  • Online ISBN: 978-1-0716-1052-7

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