Abstract
In humans, binge eating (BE) is central to the harmful effects of bulimia and binge eating disorder (BED). An estimated 30% of the obese population in the United States meets the diagnostic criteria for BED. Thus, BED is likely a major contributor to the current obesity epidemic. We developed a novel model to examine binge-like eating behavior in rodents that utilizes a schedule of 24-h weekly access to a highly palatable, nutritionally complete energy-dense diet (HED). This method for inducing BE has advantages over previous methods in that it does not require the use of exogenous stressors, caloric restriction, or entrained food anticipatory activity to induce the binge episode. Herein, we report that the BE response induced by this intermittent feeding paradigm can be maintained for at least 9 months in C57BL/6 mice. However, answers to a fundamental question remain. Can BE increase the risk of metabolic syndrome above and beyond the risk associated with obesity alone? Recent evidence in humans and rodents suggests that this may be the case. Given the high prevalence of BED in obesity, it is to be expected that there will be metabolic consequences of BE in this model and potentially in other BE models. However, the exact nature and if it is similar to that observed in frank obesity remains to be determined. We report on what is known about the metabolic consequences of long-term exposure to BE in mice with 24-h weekly access to an HED. While the changes we observed are subtle, over time they could have a significant impact on overall metabolism. Alterations in opioid receptor signaling pathways after repeated bingeing are discussed and may be one mechanism that links binge-like eating behavior with peripheral metabolism. Mice have particular advantages as a preclinical model mainly due to the sophisticated genetic techniques that are available in this species. Extensive characterization of the physiological, behavioral, and molecular changes associated with intermittent access to palatable diets will provide opportunities to identify and test novel therapeutic approaches to reduce BE and to understand its clinical translatability.
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References
Call C, Walsh BT, Attia E (2013) From DSM-IV to DSM-5: changes to eating disorder diagnoses. Curr Opin Psychiatry 26(6):532–536
Walsh BT (2019) Diagnostic categories for eating disorders: current status and what lies ahead. Psychiatr Clin North Am 42:1): 1–1):10
Hudson JI et al (2007) The prevalence and correlates of eating disorders in the National Comorbidity Survey replication. Biol Psychiatry 61(3):348–358
Wonderlich SA et al (2009) The validity and clinical utility of binge eating disorder. Int J Eat Disord 42(8):687–705
Guerdjikova AI et al (2019) Update on binge eating disorder. Med Clin North Am 103(4):669–680
Novelle MG, Diéguez C (2019) Updating gender differences in the control of homeostatic and hedonic food intake: implications for binge eating disorder. Mol Cell Endocrinol 497:110508
Samson SL, Garber AJ (2014) Metabolic syndrome. Endocrinol Metab Clin N Am 43(1):1–23
Çelik S et al (2015) Correlation of binge eating disorder with level of depression and glycemic control in type 2 diabetes mellitus patients. Gen Hosp Psychiatry 37(2):116–119
Klatzkin RR et al (2015) Binge eating disorder and obesity: preliminary evidence for distinct cardiovascular and psychological phenotypes. Physiol Behav 142:20–27
Herbozo S et al (2015) Dietary adherence, glycemic control, and psychological factors associated with binge eating among indigenous and non-indigenous Chileans with type 2 diabetes. Int J Behav Med 22(6):792–798
Raevuori A et al (2015) Highly increased risk of type 2 diabetes in patients with binge eating disorder and bulimia nervosa. Int J Eat Disord 8(6):555–562
Papelbaum M et al (2019) Does binge-eating matter for glycemic control in type 2 diabetes patients? J Eat Disord 7(1):30–36
Wang J et al (2001) Overfeeding rapidly induces leptin and insulin resistance. Diabetes 50(12):2786–2791
Ilyas A et al (2018) The metabolic underpinning of eating disorders: a systematic review and meta-analysis of insulin sensitivity. Mol Cell Endocrinol 497:110307
Wassenaar E, Friedman J, Mehler PS (2019) Medical complications of binge eating disorder. Psychiatr Clin North Am 42(2):275–286
Corwin RL, Avena NM, Boggiano MM (2011) Feeding and reward: perspectives from three rat models of binge eating. Physiol Behav 104(1):87–97
Rada P, Avena NM, Hoebel BG (2005) Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience 134(3):737–744
Corwin RL, Wojnicki FH (2006) Binge eating in rats with limited access to vegetable shortening. Curr Protoc Neurosci. Chapter 9: Unit 9.23B
Wojnicki FHE, Stine JG, Corwin RLW (2007) Liquid sucrose bingeing in rats depends on the access schedule, concentration and delivery system. Physiol Behav 92(4):566–574
Sahr AE et al (2008) Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582. Am J Physiol Regul Integr Comp Physiol 295(2):463–471
Sindelar DK et al (2005) Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides 26(12):2597–2602
Bake T, Morgan DGA, Mercer JG (2014) Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat. Physiol Behav 128(100):70–79
Teegarden SL, Bale TL (2007) Effects of stress on dietary preference and intake are dependent on access and stress sensitivity. Physiol Behav 93(4):713–723
Czyzyk TA, Sahr AE, Statnick MA (2010) A model of binge-like eating behavior in mice that does not require food deprivation or stress. Obesity (Silver Spring) 18(9):1710–1717
Cao X et al (2014) Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest 124(10):4351–4362
Schroeder M et al (2017) A methyl-balanced diet prevents CRF-induced prenatal stress-triggered predisposition to binge eating-like phenotype. Cell Metab 25(6):1269–1281.e6
Xu P et al (2016) Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice. Biol Psychiatry 81(9):737–747
Xu Y et al (2017) VMAT2-mediated neurotransmission from midbrain leptin receptor neurons in feeding regulation. eNeuro 4(3):ENEURO.0083-17.2017
Zhang X, van den Pol AN (2017) Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation. Science 356(6340):853–859
Capasso A, Petrella C, Milano W (2009) Pharmacological profile of SSRIs and SNRIs in the treatment of eating disorders. Curr Clin Pharmacol 4(1):78
Epstein LH et al (2011) Long-term habituation to food in obese and nonobese women. Am J Clin Nutr 94(2):371–376
Jumpertz R et al (2011) Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr 94(1):58–65
Krajmalnik-Brown R et al (2012) Effects of gut microbes on nutrient absorption and energy regulation. Nutr Clin Pract 27(2):201–214
Muegge BD et al (2011) Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science 332(6032):970–974
Turnbaugh PJ et al (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444(7122):1027–1031
Laughlin MR et al (2012) NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping. Mamm Genome 23(9):623–631
Mann A et al (2014) Localization, identification, and excision of murine adipose depots. J Vis Exp 94:52174
Ayala JE et al (2010) Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech 3(9–10):525–534
Mantzoros C et al (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382(6588):250–252
Bézaire V et al (2001) Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(−/−) and wild-type mice. Am J Physiol Endocrinol Metab 281(5):975–982
Heijboer AC et al (2005) Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice. J Lipid Res 46(3):582–588
Silva JP et al (2009) Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature 462(7273):646–650
Consoli D et al (2009) Binge-like eating in mice. Int J Eat Disord 42(5):402–408
Pankevich DE et al (2010) Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating. J Neurosci 30(48):16399–16407
Telensky P et al (2015) The interaction of binge-eating and stress-responsivity in mice. 45th Annual Society for Neuroscience Meeting, Program #524.03
Schroeder M et al (2018) Sex dependent impact of gestational stress on predisposition to eating disorders and metabolic disease. Mol Metab 17:1–16
Carlin JL et al (2016) Removal of high-fat diet after chronic exposure drives binge behavior and dopaminergic dysregulation in female mice. Neuroscience 326:170–179
Leibowitz SF et al (2005) Phenotypic profile of SWR/J and A/J mice compared to control strains: possible mechanisms underlying resistance to obesity on a high-fat diet. Brain Res 1047(2):137–147
Alexander J et al (2006) Distinct phenotypes of obesity-prone AKR J, DBA2J and C57BL 6J mice compared to control strains. Int J Obes 30(1):50–59
Lewis SR et al (2005) Inbred mouse strain survey of sucrose intake. Physiol Behav 85(5):546–556
Lewis SR et al (2006) Genetic variance contributes to ingestive processes: a survey of eleven inbred mouse strains for fat (Intralipid) intake. Physiol Behav 90(1):82–94
Smith BK, Andrews PK, West DB (2000) Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):797–805
Freeman HC et al (2006) Deletion of nicotinamide nucleotide transhydrogenase: a new quantitative trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes 55(7):2153–2156
King SJ et al (2016) Investigation of a role for ghrelin signaling in binge-like feeding in mice under limited access to high-fat diet. Neuroscience 319:233–245
Sinclair EB et al (2015) Differential mesocorticolimbic responses to palatable food in binge eating prone and binge eating resistant female rats. Physiol Behav 152(Pt A):249–256
Klump KL et al (2013) Sex differences in binge eating patterns in male and female adult rats. Int J Eat Disord 46(7):729–736
Boggiano MM et al (2007) High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating. Int J Obes 31(9):1357–1367
Klump KL, Culbert KM, Sisk CL (2017) Sex differences in binge eating: gonadal hormone effects across development. Annu Rev Clin Psychol 13(1):183–207
Johnson PM, Kenny PJ (2010) Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 13(5):635–641
Wang G-J et al (2011) Enhanced striatal dopamine release during food stimulation in binge eating disorder. Obesity (Silver Spring) 19(8):1601–1608
Javaras KN et al (2008) Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry 69(2):266–273
Bahji A et al (2019) Prevalence of substance use disorder comorbidity among individuals with eating disorders: a systematic review and meta-analysis. Psychiatry Res 273:58–66
Berridge KC (2009) ‘Liking’ and ‘wanting’ food rewards: brain substrates and roles in eating disorders. Physiol Behav 97(5):537–550
Shin AC et al (2010) Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens. Neuroscience 170(2):580–588
Hardaway JA et al (2016) Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behav Brain Res 307:25–34
Tabarin A et al (2005) Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a “thrifty gene”. Diabetes 54(12):3510–3516
Zuberi AR et al (2008) Increased adiposity on normal diet, but decreased susceptibility to diet-induced obesity in mu-opioid receptor-deficient mice. Eur J Pharmacol 585(1):14–23
Czyzyk TA et al (2010) kappa-opioid receptors control the metabolic response to a high-energy diet in mice. FASEB J 24(4):1151–1159
Czyzyk TA et al (2012) Mice lacking δ-opioid receptors resist the development of diet-induced obesity. FASEB J 26(8):3483–3492
Statnick MA et al (2012) Multiple subtypes of opioid receptors regulate binge-like (BE) feeding in rodents on an intermittent access schedule. FASEB J 26(1_supplement):889.5–889.5
Davis CA et al (2009) Dopamine for “wanting ” and opioids for “liking”: a comparison of obese adults with and without binge eating. Obesity (Silver Spring) 17(6):1220–1225
Sachdeo BLY et al (2019) Binge-like eating is not influenced by the murine model of OPRM1 A118G polymorphism. Front Psychol 10:246
Wee S, Koob GF (2010) The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology 210(2):121–135
Endoh T et al (1992) Nor-binaltorphimine: a potent and selective kappa-opioid receptor antagonist with long-lasting activity in vivo. Arch Int Pharmacodyn Ther 316:30–42
Acknowledgments
This work was supported by the Klarman Family Foundation Grants Program in Eating Disorders Research (TAC) and the Mayo Clinic Foundation (PT, TAC). The authors would like to thank Allison E. Sahr for guidance with intermittent access models, Paulina Smith for technical support, and the Mayo Clinic in Arizona Mouse Metabolic Phenotyping Laboratory.
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Tang, T. et al. (2021). Assessment of Binge-Like Eating Behavior in Mice Utilizing a Weekly Intermittent Access Paradigm. In: Avena, N.M. (eds) Animal Models of Eating Disorders. Neuromethods, vol 161. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0924-8_4
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DOI: https://doi.org/10.1007/978-1-0716-0924-8_4
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