Abstract
Flow infusion ESI high resolution (0.4–3 ppm mass error) mass spectrometric metabolomics allows for the analysis of a broad array of metabolites of interest. The issue of isobars must always be assessed carefully and can be managed by tandem mass spectrometry, by derivatization prior to direct infusion analyses, and/or via the use of chromatographic systems.
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References
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Acknowledgments
I wish to thank my clinical collaborators and the many students whose rotations in the Metabolomics Unit have aided in building and validating the metabolomics platform described in this chapter. In addition this work would have not been possible without the financial support of Lincoln Memorial University and the DOJ.
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Wood, P.L. (2021). Flow Infusion ESI High Resolution Mass Spectrometry Metabolomics Analytical Platforms. In: Wood, P.L. (eds) Metabolomics . Neuromethods, vol 159. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0864-7_1
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DOI: https://doi.org/10.1007/978-1-0716-0864-7_1
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