Abstract
The tissue response to injury is a complex process. The cornea is an excellent model for studying wound repair processes because of its simple anatomy, easy accessibility, and normal avascular state. Here, we describe two corneal repair models in mice: an epithelial/mechanical injury model and a stromal/chemical injury model. The two models induce different repair responses, and consequently enable the study of independent repair processes. Here, we describe how these two wound models may be used to study basic cellular and molecular mechanisms of corneal repair.
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Acknowledgments
We thank Suling Wang for assistance with preparing and illustrating the figures of the corneal wound models. This work was supported by grants from the National Institutes of Health (R01 EY022739 to M.F.C; NIH-NEI EY002162 - Core Grant for Vision Research), Research to Prevent Blindness (RPB Physician-Scientist Award to MFC; RPB Unrestricted Grant to the UCSF Department of Ophthalmology), and That Man May See.
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Pan, P., Chan, M.F. (2021). Corneal Repair Models in Mice: Epithelial/Mechanical Versus Stromal/Chemical Injuries. In: Das, H. (eds) Wound Regeneration. Methods in Molecular Biology, vol 2193. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0845-6_15
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DOI: https://doi.org/10.1007/978-1-0716-0845-6_15
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