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EMT: An Update

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The Epithelial-to Mesenchymal Transition

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2179))

Abstract

Epithelial Mesenchymal Transition (EMT) initially discovered as a key developmental mechanism is now shown to be indirectly involved in fibrosis and is contributing to the progression of carcinomas. Additionally, to transcription factors driving the morphological transition, novel mechanisms are now described to modulate the different features of the transition. The debate as to whether EMT is essential for the dissemination of carcinoma cells from the primary tumors is likely to be resolved soon, considering that EMT is not a linear transition from an epithelial to a mesenchymal state. Multiple intermediate states can be reached without involving the presence of some of known transcription factors initially described as indispensable for the acquisition of mesenchymal-like phenotypes.

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Author information

Authors and Affiliations

  1. Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China

    Jean Paul Thiery

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  1. Jean Paul Thiery
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Correspondence to Jean Paul Thiery .

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Editors and Affiliations

  1. Department of Biomedical Science and Bateson Centre, University of Sheffield, Sheffield, UK

    Kyra Campbell

  2. Centre de Biologie du Développement (CBD) Centre de Biologie Intégrative (CBI), Université de Toulouse, Toulouse, France

    Eric Theveneau

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Thiery, J.P. (2021). EMT: An Update. In: Campbell, K., Theveneau, E. (eds) The Epithelial-to Mesenchymal Transition. Methods in Molecular Biology, vol 2179. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0779-4_6

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  • DOI: https://doi.org/10.1007/978-1-0716-0779-4_6

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0778-7

  • Online ISBN: 978-1-0716-0779-4

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