Skip to main content

Roles of Pathological Assessments of Frozen Sections in Esophageal Squamous Cell Carcinoma

  • Protocol
  • First Online:
Esophageal Squamous Cell Carcinoma

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2129))

  • 818 Accesses

Abstract

Pathological assessment of frozen sections of tissues is important in the clinical management (intraoperative consultation) and research in patients with esophageal squamous cell carcinoma. Frozen sections may be used in the assessment of status of resection margins, extent of cancer metastasis (pathological staging), confirmation of the pathology, and increased volume of cancer cells for tissue banking. However, the applications of frozen sections have many technical limitations. Thus, interpretation of frozen sections needs expertise, collaborations, and attention to proper technical skills in the sectioning.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Dai W, Ko JMY, Choi SSA, Yu Z, Ning L, Zheng H, Gopalan V, Chan KT, Lee NP, Chan KW, Law SY, Lam AK, Lung ML (2017) Whole-exome sequencing reveals critical gene underlying metastasis in oesophageal squamous cell carcinoma. J Pathol 242:500–510

    Article  CAS  Google Scholar 

  2. Kwong D, Lam A, Guan X, Law S, Tai A, Wong J, Sham J (2004) Chromosomal aberrations in esophageal squamous cell carcinoma among Chinese: gain of 12p predicts poor prognosis after surgery. Hum Pathol 35:309–316

    Article  CAS  Google Scholar 

  3. Haque MH, Gopalan V, Chan KW, Shiddiky MJ, Smith RA, Lam AK (2016) Identification of novel FAM134B (JK1) mutations in oesophageal squamous cell carcinoma. Sci Rep 6:29173

    Article  CAS  Google Scholar 

  4. Nayanar SK, M AK IMK, Thavarool PSB, Thiagarajan S (2019) Frozen section evaluation in head and neck oncosurgery: an initial experience in a tertiary cancer center. Turk Patoloji Derg 35:46–51

    PubMed  Google Scholar 

  5. Lam KY, Lo CY (2002) Metastatic tumours of the adrenal glands: a 30-year experience in a teaching hospital. Clin Endocrinol 56:95–101

    Article  Google Scholar 

  6. Lam KY, Tang V (2000) Metastatic tumors to the spleen: a 25-year clinicopathologic study. Arch Pathol Lab Med 124:526–530

    CAS  PubMed  Google Scholar 

  7. Lam KY, Dickens P, Chan AC (1993) Tumors of the heart: a 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med 117:1027–1031

    CAS  PubMed  Google Scholar 

  8. Fritz S, Hackert T, Blaker H, Hartwig W, Schneider L, Buchler MW, Werner J (2006) Multiple von Meyenburg complexes mimicking diffuse liver metastases from esophageal squamous cell carcinoma. World J Gastroenterol 12:4250–4252

    Article  Google Scholar 

  9. Chiu CH, Chao YK, Wen YW, Chang HK, Tseng CK, Liu YH (2017) Unexpected microscopically positive proximal resection margins in esophageal squamous cell carcinoma after chemoradiotherapy: predictors and prognostic significance. World J Surg 41:191–199

    Article  Google Scholar 

  10. Lam KY, Law S, Wong J (2003) Low prevalence of incidentally discovered and early-stage esophageal cancers in a 30-year autopsy study. Dis Esophagus 16:1–3

    Article  Google Scholar 

  11. Lam KY, Ma LT, Wong J (1996) Measurement of extent of spread of oesophageal squamous carcinoma by serial sectioning. J Clin Pathol 49:124–129

    Article  CAS  Google Scholar 

  12. Hagihara T, Uenosono Y, Arigami T, Kozono T, Arima H, Yanagita S, Hirata M, Ehi K, Okumura H, Matsumoto M, Uchikado Y, Ishigami S, Natsugoe S (2013) Assessment of sentinel node concept in esophageal cancer based on lymph node micrometastasis. Ann Surg Oncol 20:3031–3037

    Article  Google Scholar 

  13. Akutsu Y, Kato K, Igaki H, Ito Y, Nozaki I, Daiko H, Yano M, Udagawa H, Nakagawa S, Takagi M, Mizusawa J, Kitagawa Y (2016) The prevalence of overall and initial lymph node metastases in clinical t1n0 thoracic esophageal cancer: from the results of jcog0502, a prospective multicenter study. Ann Surg 264:1009–1015

    Article  Google Scholar 

  14. Kumakura Y, Yokobori T, Yoshida T, Hara K, Sakai M, Sohda M, Miyazaki T, Yokoo H, Handa T, Oyama T, Yorifuji H, Kuwano H (2018) Elucidation of the anatomical mechanism of nodal skip metastasis in superficial thoracic esophageal squamous cell carcinoma. Ann Surg Oncol 25:1221–1228

    Article  Google Scholar 

  15. Thomson AM, Wallace WA (2007) Fixation artefact in an intra-operative frozen section: a potential cause of misinterpretation. J Cardiothorac Surg 2:45

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alfred K. Lam .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Science+Business Media, LLC, part of Springer Nature

About this protocol

Check for updates. Verify currency and authenticity via CrossMark

Cite this protocol

Lam, A.K. (2020). Roles of Pathological Assessments of Frozen Sections in Esophageal Squamous Cell Carcinoma. In: Lam, A. (eds) Esophageal Squamous Cell Carcinoma. Methods in Molecular Biology, vol 2129. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0377-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-0716-0377-2_7

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0376-5

  • Online ISBN: 978-1-0716-0377-2

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics