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An Overview of Advances in Cell-Based Cancer Immunotherapies Based on the Multiple Immune-Cancer Cell Interactions

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Cell Reprogramming for Immunotherapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2097))

Abstract

Tumors have a complex ecosystem in which behavior and fate are determined by the interaction of diverse cancerous and noncancerous cells at local and systemic levels. A number of studies indicate that various immune cells participate in tumor development (Fig. 1). In this review, we will discuss interactions among T lymphocytes (T cells), B cells, natural killer (NK) cells, dendritic cells (DCs), tumor-associated macrophages (TAMs), neutrophils, and myeloid-derived suppressor cells (MDSCs). In addition, we will touch upon attempts to either use or block subsets of immune cells to target cancer.

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Authors and Affiliations

  1. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Jialing Zhang & Samuel G. Katz

  2. Department of Genetics, Yale School of Medicine, New Haven, CT, USA

    Jialing Zhang & Sherman M. Weissman

  3. University of Tübingen, Tübingen, Germany

    Stephan S. Späth

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  1. Jialing Zhang
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  2. Stephan S. Späth
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  3. Sherman M. Weissman
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  4. Samuel G. Katz
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Correspondence to Samuel G. Katz .

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Editors and Affiliations

  1. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Samuel G. Katz

  2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Peter M. Rabinovich

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Zhang, J., Späth, S.S., Weissman, S.M., Katz, S.G. (2020). An Overview of Advances in Cell-Based Cancer Immunotherapies Based on the Multiple Immune-Cancer Cell Interactions. In: Katz, S., Rabinovich, P. (eds) Cell Reprogramming for Immunotherapy. Methods in Molecular Biology, vol 2097. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0203-4_10

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  • DOI: https://doi.org/10.1007/978-1-0716-0203-4_10

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