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Seizures

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Acute Pediatric Neurology

Abstract

Seizures occur from excessive cortical excitation and their clinical manifestations vary depending upon the cortical areas involved. Seizures may occur in a patient with underlying epilepsy or result from an acute central nervous system (CNS) insult. This chapter defines the various terms used in describing seizures, the classification, the pathophysiology, and the various clinical manifestations of seizures. We will also describe the diagnostic studies needed for seizures, especially the electroencephalogram (EEG). The treatment of seizures and status epilepticus is reviewed in Chap. 10.

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References

  1. Lowenstein DH, Bleck T, Macdonald RL. It’s time to revise the definition of status epilepticus. Epilepsia. 1999;40:120–2.

    Article  PubMed  CAS  Google Scholar 

  2. Blume WT, Luders HO, Mizrahi E. Glossary of descriptive terminology for ictal semiology: report of the ILAE Task Force on Classification and Terminology. Epilepsia. 2001;42:1212–18.

    Article  PubMed  CAS  Google Scholar 

  3. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde BW, Engel J, French J, Glauser TA, Mathern GW, Moshe SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE commission on classification and terminology, 2005–2009. Epilepsia. 2010;51:676–85.

    Article  PubMed  Google Scholar 

  4. Abend NS, Gutierrez-Colina AM, Topjian AA, Zhao H, Guo R, Donnelly M, Clancy RR, Dlugos DJ. Nonconvulsive seizures are common in critically ill children. Neurology. 2011;76:1071–7.

    Article  PubMed  CAS  Google Scholar 

  5. Vespa PM, O’Phelan K, Shah M, et al. Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology. 2003;60:1441–6.

    Article  PubMed  CAS  Google Scholar 

  6. Vespa PM, Miller C, McArthur D, et al. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007;35:2830–6.

    Article  PubMed  Google Scholar 

  7. Riviello JJJR, Holmes GL. The treatment of status epilepticus. Semin Pediatr Neurol. 2004;11:129–38.

    Article  PubMed  Google Scholar 

  8. Lothman E. The biochemical basis and pathophysiology of status epilepticus. Neurology. 1990;40 Suppl 2:13–23.

    PubMed  CAS  Google Scholar 

  9. Riviello JJ, AshwalShirtz D, Glauser T, Ballaban-Gil K, Kelley K, Morton LD, Phillips S, Sloan E, Shinnar S. Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology and the practice committee of the Child Neurology Society. Neurology. 2006;67:1542–50.

    Article  PubMed  Google Scholar 

  10. Chin RFM, Neville BGR, Peckham C, Bedford H, Wade A, Scott RC. Incidence, cause, and short-term outcome of convulsive status epilepticus in children: prospective, population-based study. Lancet. 2006;368:222–22945.

    Article  PubMed  Google Scholar 

  11. Schwartzkroin PA, Baraban SC, Hochman DW. Osmolarity, ion flux, and changes in brain excitability. Epilepsy Res. 1998;32:275–85.

    Article  PubMed  CAS  Google Scholar 

  12. Castilla-Guerra L, del Carmen F-MM, Lopez-Chozas JM, Fernandez-Bolanos R. Electrolyte disturbances and seizures. Epilepsia. 2006;47:1990–8.

    Article  PubMed  CAS  Google Scholar 

  13. Goodkin HP. Impact of receptor changes on treatment of status epilepticus. Epilepsia. 2007;48 Suppl 8:14–5.

    Article  PubMed  Google Scholar 

  14. Gabor AJ, Brooks AG, Scobey RP, Parsons GH. Intracranial pressure during epileptic seizures. Electroencephalogr Clin Neurophysiol. 1984;57:497–506.

    Article  PubMed  CAS  Google Scholar 

  15. Goodkin HP, Liu X, Holmes GL. Diazepam terminates brief but not prolonged seizures in young, naive rats. Epilepsia. 2003;44:1109–12.

    Article  PubMed  CAS  Google Scholar 

  16. Nordli DR, Kuroda MM, Hirsch LJ. The ontogeny of partial seizures in infants and young children. Epilepsia. 2001;42:986–90.

    Article  PubMed  Google Scholar 

  17. Husain AM, Horn GJ, Jacobson MP. Non-convulsive status epilepticus: usefulness of clinical features in selecting patients for urgent EEG. J Neurol Neurosurg Psychiatry. 2003;74:189–91.

    Article  PubMed  CAS  Google Scholar 

  18. Singh RK, Stephens S, Berl MM, Chang T, Brown K, Vezina LG, Gaillard WD. Prospective study of new-onset seizures presenting as status epilepticus. Neurology. 2010;74:636–42.

    Article  PubMed  CAS  Google Scholar 

  19. Freilich ER, Zelleke T, Gaillaird WD. Identification and evaluation of the child in status epilepticus. Semin Pediatr Neurol. 2010;17:144–9.

    Article  PubMed  Google Scholar 

  20. Greenberg MK, Barsan WG, Starkman S. Practice parameter: neuroimaging in the emergency patient presenting with seizure. Neurology. 1996;47:26–32.

    Article  PubMed  CAS  Google Scholar 

  21. Sharma S, Riviello JJ, Harper MB, Baskin MN. The role of emergent neuroimaging in children with new-onset afebrile seizures. Pediatrics. 2003;111:1–5.

    Article  PubMed  Google Scholar 

  22. DeLorenzo RJ, Waterhouse EJ, Towne AR, Boggs JG, Ko D, DeLorenzo GA, Brown A, Garnett L. Persistent nonconvulsive status epilepticus after control of generalized convulsive status epilepticus. Epilepsia. 1998;39:833–40.

    Article  PubMed  CAS  Google Scholar 

  23. Tay SKH, Hirsch LJ, Leary L, Jette N, Wittman J, Akman CI. Nonconvulsive status epilepticus in children: clinical and EEG characteristics. Epilepsia. 2006;47:1504–9.

    Article  PubMed  Google Scholar 

  24. Towne AR, Waterhouse EJ, Boggs JG, Garnett LK, Brown AJ, Smith Jr JR, DeLorenzo RJ. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology. 2000;54:340–5.

    Article  PubMed  CAS  Google Scholar 

  25. Privitera MD, Strawsburg RH. Electroencephalographic monitoring in the emergency department. Emerg Med Clin North Am. 1994;12:1089–101.

    PubMed  CAS  Google Scholar 

  26. Thomas P. Status epileptics: indications for emergency EEG. Neurophysiol Clin. 1997;27:398–405.

    Article  PubMed  CAS  Google Scholar 

  27. Pakalnis A, Paolicchi J, Gilles E. Psychogenic status epilepticus in children: psychiatric and other risk factors. Neurology. 2000;54:969–70.

    Article  PubMed  CAS  Google Scholar 

  28. Shahwan A, Bailey C, Shekerdemian L, Harvey SA. The prevalence of seizures in comatose children in the pediatric intensive care unit: a prospective video-EEG study. Epilepsia. 2010;51:1198–204.

    Article  PubMed  Google Scholar 

  29. Abend NS, Topjian AA, Gutierrez-Colina AM, Donnelly M, Clancy RR, Dlugos DJ. Impact of continuous EEG monitoring on clinical management in critically ill children. Neurocrit Care. 2010;15:70–5.

    Article  Google Scholar 

  30. Jette N, Claassen J, Emerson RG, Hirsch LJ. Frequency and predictors of nonconvulsive seizures during continuous electroencephalographic monitoring in critically ill children. Arch Neurol. 2006;63:1750–5.

    Article  PubMed  Google Scholar 

  31. Watemberg N, Segal G. A suggested approach to the etiologic evaluation of status epilepticus in children: what to seek after the usual causes have been ruled out. J Child Neurol. 2010;25:203–2011.

    Article  PubMed  Google Scholar 

  32. Bleck TP. Less common etiologies of status epilepticus. Epilepsy Curr. 2010;10:31–3.

    Article  PubMed  Google Scholar 

  33. Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O’Dell C, Shields WD, Trevathan E, Wheless JW. Infantile spasms: a U.S. consensus report. Epilepsia 2010;51:2175–89.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Pediatric Neurology, Department of Neurology, New York University School of Medicine, New York, NY, USA

    James J. Riviello Jr. MD

  2. NYU Comprehensive Epilepsy Center, NYU Langone Medical Center, New York, NY, USA

    James J. Riviello Jr. MD

  3. Department of Neurosciences, UCL Institute of Child Health, London, UK

    Rod C. Scott MD, PhD

Authors
  1. James J. Riviello Jr. MD
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  2. Rod C. Scott MD, PhD
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Corresponding author

Correspondence to James J. Riviello Jr. MD .

Editor information

Editors and Affiliations

  1. Department of Pediatric Neurology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital, Stockholm, Sweden

    Thomas Sejersen

  2. Department of Pediatric Neurology, Driscoll Children's Hospital, Corpus Christi, Texas, USA

    Ching H. Wang

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© 2014 Springer-Verlag London

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Riviello, J.J., Scott, R.C. (2014). Seizures. In: Sejersen, T., Wang, C. (eds) Acute Pediatric Neurology. Springer, London. https://doi.org/10.1007/978-0-85729-491-3_2

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  • DOI: https://doi.org/10.1007/978-0-85729-491-3_2

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-490-6

  • Online ISBN: 978-0-85729-491-3

  • eBook Packages: MedicineMedicine (R0)

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