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Cancer Epidemiology

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Handbook of Epidemiology
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Abstract

Cancer encompasses a family of several hundreds of diseases which are distinguished by site, morphology, clinical behavior, and response to therapy. Whether considered from a biological, a clinical, or a public health point of view, it is the malignant and invasive nature of many of these diseases and their ability to spread to distant organs (metastasis) that are of dominant importance.

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References

  • Adami H-O, Hunter D, Trichopoulos D (eds) (2008) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York

    Google Scholar 

  • Andriole GL, Crawford ED, Grubb RL 3rd, Buys SS, Chia D, Church TR, Fouad MN, Isaacs C, Kvale PA, Reding DJ, Weissfeld JL, Yokochi LA, O’Brien B, Ragard LR, Clapp JD, Rathmell JM, Riley TL, Hsing AW, Izmirlian G, Pinsky PF, Kramer BS, Miller AB, Gohagan JK, Prorok PC, PLCO Project Team (2012) Prostate cancer screening in the randomized prostate, lung, colorectal, and ovarian cancer screening trial: mortality results after 13 years of follow-up. J Natl Cancer Inst 104:125–132

    Google Scholar 

  • Arbyn M, Ronco G, Anttila A, Meijer CJ, Poljak M, Ogilvie G, Koliopoulos G, Naucler P, Sankaranarayanan R, Peto J (2012) Evidence regarding human papilloma virus testing in secondary prevention of cervical cancer. Vaccine 30(Suppl 5):F88–F99

    Article  PubMed  Google Scholar 

  • Beral V, Million Women Study Collaborators (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362:419–427

    Article  CAS  PubMed  Google Scholar 

  • Boffetta P (2006) Human cancer from environmental pollutants: the epidemiological evidence. Mutat Res 608:157–162

    Article  CAS  PubMed  Google Scholar 

  • Boffetta P (2010) Biomarkers in cancer epidemiology: an integrative approach. Carcinogenesis 31:121–126

    Article  CAS  PubMed  Google Scholar 

  • Boffetta P, Hashibe M (2006). Alcohol and cancer. Lancet Oncol 7:149–156

    Article  CAS  PubMed  Google Scholar 

  • Boffetta P, Trichopoulos D (2008) Biomarkers in cancer epidemiology. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 109–126

    Chapter  Google Scholar 

  • Boffetta P, Kogevinas M, Simonato L, Wilbourn J, Saracci R (1995) Current perspectives on occupational cancer risks. Int J Occup Environ Health 1:315–325

    Article  PubMed  Google Scholar 

  • Boffetta P, Hecht S, Gray N, Gupta P, Straif K (2008a) Smokeless tobacco and cancer. Lancet Oncol 9:667–675

    Article  PubMed  Google Scholar 

  • Boffetta P, McLaughlin JK, La Vecchia C, Tarone RE, Lipworth L, Blot WJ (2008b) False-positive results in cancer epidemiology: a plea for epistemological modesty. J Natl Cancer Inst 100: 988–995

    Article  PubMed Central  PubMed  Google Scholar 

  • Boffetta P, Tubiana M, Hill C, Boniol M, Aurengo A, Masse R, Valleron AJ, Monier R, de Thé G, Boyle P, Autier P (2009) The causes of cancer in France. Ann Oncol 20:550–555

    Article  CAS  PubMed  Google Scholar 

  • Boyle P, Autier P, Bartelink H, Baselga J, Boffetta P, Burn J, Burns HJG, Christensen L, Denis L, Dicato M, Diehl V, Doll R, Franceschi S, Gillis CR, Gray N, Griciute L, Hackshaw A, Kasler M, Kogevinas M, Kvinnsland S, La Veccia C, Levi F, McVie JG, Maisonneuve P, Martin-Moreno M, Newton Bishop J, Oleari F, Perrin P, Quinn M, Richards M, Ringborg U, Scully C, Siracka E, Storm H, Tubiana M, Tursz T, Veronesi U, Wald N, Weber W, Zaridze DG, Zatonski W, zur Hausen H (2003) European code against cancer and scientific justification: third version. Ann Oncol 14:973–1005

    Article  CAS  PubMed  Google Scholar 

  • Breslow NE, Day NE (1980) Statistical methods in cancer research, vol I. The analysis of case-control studies. IARC scientific publications no. 32. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • Breslow NE, Day NE (1987) Statistical methods in cancer research, vol II. The design and analysis of cohort studies. IARC scientific publications no. 82. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • CGHFBC (Collaborative Group on Hormonal Factors in Breast Cancer) (1996) Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies. Lancet 347:1713–1727

    Article  Google Scholar 

  • CGHFBC (Collaborative Group on Hormonal Factors in Breast Cancer) (1997) Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 350:1047–1059

    Article  Google Scholar 

  • CGHFBC (Collaborative Group on Hormonal Factors in Breast Cancer) (2002) Breast cancer and breast feeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50,302 women with breast cancer and 96,973 women without the disease. Lancet 360:187–195

    Article  Google Scholar 

  • Chen CH, Dickman KG, Moriya M, Zavadil J, Sidorenko VS, Edwards KL, Gnatenko DV, Wu L, Turesky RJ, Wu XR, Pu YS, Grollman AP (2012) Aristolochic acid-associated urothelial cancer in Taiwan. Proc Natl Acad Sci USA 109:8241–8246

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Clayton PE, Banerjee I, Murray PG, Renehan AG (2011) Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol 7:11–24

    Article  CAS  PubMed  Google Scholar 

  • Cuzick J, Bergeron C, von Knebel Doeberitz M, Gravitt P, Jeronimo J, Lorincz AT, J L M Meijer C, Sankaranarayanan R, J F Snijders P, Szarewski A (2012) New technologies and procedures for cervical cancer screening. Vaccine 30(Suppl 5):F107–F116

    Google Scholar 

  • de Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D, Plummer M (2012) Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol 13:607–615

    Article  PubMed  Google Scholar 

  • DeVivo I, Persson I, Adami HO (2008) Endometrial cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 468–493

    Chapter  Google Scholar 

  • Doll R (1998) Uncovering the effects of smoking: historical perspective. Stat Methods Med Res 7:87–117

    Article  CAS  PubMed  Google Scholar 

  • Doll R, Peto R (1981) The causes of cancer. Oxford University Press, New York, NY

    Google Scholar 

  • Doll R, Peto R (2005) Epidemiology of cancer. In: Warrell DA, Cox TM, Firth JD (eds) Oxford textbook of medicine, 4th edn. Oxford University Press, Oxford, pp 193–218

    Google Scholar 

  • ECCSGWG (European Colorectal Cancer Screening Guidelines Working Group) (2013) European guidelines for quality assurance in colorectal cancer screening and diagnosis: overview and introduction to the full supplement publication. Endoscopy 45:51–59

    Article  Google Scholar 

  • Faulds MH, Dahlman-Wright K (2012). Metabolic diseases and cancer risk. Curr Opin Oncol 24:58–61

    Article  CAS  PubMed  Google Scholar 

  • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (eds) (2010) GLOBOCAN 2008: cancer incidence and mortality worldwide. IARC CancerBase series and related publications. International Agency for Research on Cancer, Lyon. See also http://globocon.iarc.fr. Accessed 3 Jan 2013

  • Feychting M, Ahlbom A, Kheifets L (2005) EMF and health. Annu Rev Public Health 26:165–189

    Article  PubMed  Google Scholar 

  • Gandini S, Botteri E, Iodice S, Boniol M, Lowenfels AB, Maisonneuve P, Boyle P (2008) Tobacco smoking and cancer: a meta-analysis. Int J Cancer 122:155–164

    Article  CAS  PubMed  Google Scholar 

  • Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, Suzuki N, Fernandes A, Rosenquist T, Medverec Z, Jakovina K, Brdar B, Slade N, Turesky RJ, Goodenough AK, Rieger R, Vukelić M, Jelaković B (2007) Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA 104:12129–12134

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Haiman C, Hunter D (2008) Genetic epidemiology of cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 86–106

    Chapter  Google Scholar 

  • Hankinson S, Tamini R, Hunter D (2008) Breast cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 403–445

    Chapter  Google Scholar 

  • HCCP (Harvard Center for Cancer Prevention) (1996) Harvard report on cancer prevention, vol 1, causes of human cancer. Cancer Causes Control 7:S3–S58

    Google Scholar 

  • Henschke CI, McCauley DI, Yankelevitz DF, Naidich DP, McGuinness G, Miettinen OS, Libby DM, Pasmantier MW, Koizumi J, Altorki NK, Smith JP (1999) Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet 354:99–105

    Article  CAS  PubMed  Google Scholar 

  • Holmes MD, Hunter DJ, Colditz GA, Stampfer MJ, Hankinson SE, Speizer FE, Rosner B, Willett WC (1999) Association of dietary intake of fat and fatty acids with risk of breast cancer. JAMA 281:914–920

    Article  CAS  PubMed  Google Scholar 

  • IARC (International Agency for Research on Cancer) (1999) Hormonal contraception and post-menopausal hormonal therapy. IARC monographs on the evaluation of carcinogenic risks to humans, vol 72. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2000) Ionizing radiation, Part 1, X- and gamma (γ)-radiation and neutrons. IARC monographs on the evaluation of carcinogenic risks to humans, vol 75. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2003) Tobacco smoking and involuntary tobacco smoke. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 83. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2010) A review of human carcinogens. Part B: biological agents. IARC monographs on the evaluation of carcinogenic risks to humans, vol 100. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2011) A review of human carcinogens. Part A: pharmaceuticals. IARC monographs on the evaluation of carcinogenic risks to humans, vol 100. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2012a) A review of human carcinogens. Part C: arsenic, metals, fibres, and dusts. IARC monographs on the evaluation of carcinogenic risks to humans, vol 100. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2012b) A review of human carcinogens. Part F: chemical agents and related occupations. IARC monographs on the evaluation of carcinogenic risks to humans, vol 100. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2012c) A review of human carcinogens. Part D: radiation. IARC monographs on the evaluation of carcinogenic risks to humans, vol 100. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90

    Article  PubMed  Google Scholar 

  • Lagiou P, Trichopoulos D, Adami HO (2008) Concepts in cancer epidemiology and etiology. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 127–154

    Chapter  Google Scholar 

  • Melbye M, Smedby KE, Trichopoulos D (2008) Non-Hodgkin’s lymphoma. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 669–693

    Chapter  Google Scholar 

  • Miller AB (1999) Cervix cancer. In: Kramer BS, Gohagan JK, Prorok PC (eds) Cancer screening: theory and practice. Marcel Dekker, New York, pp 195–217

    Google Scholar 

  • Moolgavkar S, Krewski D, Schwarz M (1999) Mechanisms of carcinogenesis and biologically based models for estimation and prediction of risk. In: Moolgavkar S, Krewski D, Zeise L, Cardis E, Møller H (eds) Quantitative estimation and prediction of human cancer risks. IARC scientific publications 131. International Agency for Research on Cancer, Lyon, pp 179–237

    Google Scholar 

  • Morgan GJ, Linet MS, Rabkin CS (2006) Immunologic factors. In: Schottenfeld D, Fraumeni JF (eds) Cancer epidemiology and prevention, 3rd edn. Oxford University Press, New York, pp 549–561

    Chapter  Google Scholar 

  • NLSTRT (National Lung Screening Trial Research Team), Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, Sicks JD (2011) Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365:395–409

    Article  PubMed  Google Scholar 

  • Nyrén O, Adami H-O (2008a) Esophageal cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 196–238

    Chapter  Google Scholar 

  • Nyrén O, Adami H-O (2008b) Stomach cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 239–276

    Chapter  Google Scholar 

  • Parkin DM, Pisani P, Lopez AD, Masuyer E (1994) At least one in seven cases of cancer is caused by smoking. Global estimates for 1985. Int J Cancer 59:494–504

    Article  CAS  PubMed  Google Scholar 

  • Parkin DM, Boyd L, Walker LC (2011) The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer 105(Suppl 2):S77–S81

    Article  PubMed Central  PubMed  Google Scholar 

  • Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R (2000) Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 321:323–329

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Potter JD, Hunter D (2008) Colorectal cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 275–307

    Chapter  Google Scholar 

  • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371:569–578

    Article  PubMed  Google Scholar 

  • Ries LAG, Young JL, Keel GE, Eisner MP, Lin YD, Horner MJ (eds) (2007) SEER Survival Monograph: cancer survival among adults: U.S. SEER Program, 1988–2001, Patient and Tumor Characteristics. National Cancer Institute/SEER Program, Bethesda

    Google Scholar 

  • Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA (2011) Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ 342:d671

    Article  PubMed Central  PubMed  Google Scholar 

  • Rothman N, Hainaut P, Schulte P, Smith M, Boffetta P, Perera F (2012) Molecular epidemiology: principles and practices. IARC scientific publications no. 163. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • Sankaranarayanan R, Ramadas K, Thomas G, Muwonge R, Thara S, Mathew B, Rajan B, Trivandrum Oral Cancer Screening Study Group (2005) Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet 365:1927–1933

    Article  PubMed  Google Scholar 

  • Sankaranarayanan R, Swaminathan R, Lucas E (2011) Cancer survival in Africa, Asia, the Caribbean and Central America (SurvCan). IARC scientific publications 162. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R, EUROCARE Working Group (2009) EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. Eur J Cancer 45:931–991

    Article  PubMed  Google Scholar 

  • Santana VS, Ribeiro FS (2011) Occupational cancer burden in developing countries and the problem of informal workers. Environ Health 10(Suppl 1):S10

    Article  PubMed Central  PubMed  Google Scholar 

  • Schottenfeld D, Fraumeni JF (eds) (2006) Cancer epidemiology and prevention, 3rd edn. Oxford University Press, New York

    Google Scholar 

  • Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Páez A, Määttänen L, Bangma CH, Aus G, Carlsson S, Villers A, Rebillard X, van der Kwast T, Kujala PM, Blijenberg BG, Stenman UH, Huber A, Taari K, Hakama M, Moss SM, de Koning HJ, Auvinen A, ERSPC Investigators (2012) Prostate-cancer mortality at 11 years of follow-up. N Engl J Med 366:981–990

    Article  PubMed  Google Scholar 

  • Smith RA, Cokkinides V, Brooks D, Saslow D, Brawley OW (2010) Cancer screening in the United States, 2010: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin 60:99–119

    Article  PubMed  Google Scholar 

  • Taubes G (1995) Epidemiology faces its limits. Science 269:164–169

    Article  CAS  PubMed  Google Scholar 

  • Thomas DC (2000) Genetic epidemiology with a capital “E”. Genet Epidemiol 19:289–300

    Article  CAS  PubMed  Google Scholar 

  • UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) (2010) Sources and effects of ionizing radiation. UNSCEAR 2008 report to the General Assembly with scientific annexes. United Nations, New York

    Google Scholar 

  • USDHHS (US Department of Health and Human Services), Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health (2004) The health consequences of smoking: a report of the Surgeon General. USDHHS, Washington, DC

    Google Scholar 

  • Verberne L, Bach-Faig A, Buckland G, Serra-Majem L (2010) Association between the Mediterranean diet and cancer risk: a review of observational studies. Nutr Cancer 62:860–870

    Article  PubMed  Google Scholar 

  • Wang JB, Jiang Y, Liang H, Li P, Xiao HJ, Ji J, Xiang W, Shi JF, Fan YG, Li L, Wang D, Deng SS, Chen WQ, Wei WQ, Qiao YL, Boffetta P (2012) Attributable causes of cancer in China. Ann Oncol 23:2983–2989

    Article  CAS  PubMed  Google Scholar 

  • WCRF (World Cancer Research Fund/American Institute for Cancer Research) (1997) Food, nutrition and the prevention of cancer: a global perspective. World Cancer Research Fund & American Institute for Cancer Research, Washington, DC

    Google Scholar 

  • WCRF (World Cancer Research Fund/American Institute for Cancer Research) (2007) Food, nutrition, physical activity and the prevention of cancer: a global perspective. World Cancer Research Fund & American Institute for Cancer Research, Washington, DC

    Google Scholar 

  • Xue F, Michels KB (2007) Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. Lancet Oncol 8:1088–1100

    Article  PubMed  Google Scholar 

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Boffetta, P. (2014). Cancer Epidemiology. In: Ahrens, W., Pigeot, I. (eds) Handbook of Epidemiology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09834-0_36

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  • DOI: https://doi.org/10.1007/978-0-387-09834-0_36

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