Abstract
Host-pathogen interactions involve complex inside-out and outside-in signal transmission through critical cellular networks that dictate disease outcomes. The phosphoinositide 3-kinase (PI3K)/Akt pathway is a pivotal junction that regulates several cell functions, and phospho-Akt (pAkt) is often found to be constitutively active in cancer cells, similar to phospho-STAT3. In this chapter, we discuss the regulation of PI3K/Akt pathway in VZV infected cells and of other pathways including p53 which, unlike pAkt and pSTAT3, directs cells towards apoptosis. The fine spatio-temporal balance of activation of pro- and anti-apoptotic factors during VZV infection likely provides an optimum environment for the virus to replicate and cause disease in the human host.
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Sen, N., Arvin, A.M. (2021). Modulation of Host Cell Signaling Pathways by Varicella-Zoster Virus. In: Arvin, A.M., Moffat, J.F., Abendroth, A., Oliver, S.L. (eds) Varicella-zoster Virus. Current Topics in Microbiology and Immunology, vol 438. Springer, Cham. https://doi.org/10.1007/82_2021_251
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DOI: https://doi.org/10.1007/82_2021_251
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