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Staphylococcus aureus-Associated Musculoskeletal Infections

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Staphylococcus aureus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 409))

Abstract

Musculoskeletal infections caused by Staphylococcus aureus are among the most difficult-to-treat infections. S. aureus osteomyelitis is associated with a tremendous disease burden through potential for long-term relapses and functional deficits. Although considerable advances have been achieved in diagnosis and treatment of osteomyelitis, the management remains challenging and impact on quality of life is still enormous. S. aureus acute arthritis is relatively seldom in general population, but the incidence is considerably higher in patients with predisposing conditions, particularly those with rheumatoid arthritis. Rapidly destructive course with high mortality and disability rates makes urgent diagnosis and treatment of acute arthritis essential. S. aureus pyomyositis is a common disease in tropical countries, but it is very seldom in temperate regions. Nevertheless, the cases have been increasingly reported also in non-tropical countries, and the physicians should be able to timely recognize this uncommon condition and initiate appropriate treatment. The optimal management of S. aureus-associated musculoskeletal infections requires a strong interdisciplinary collaboration between all involved specialists.

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References

  • Agarwal JP, Ogilvie M, Wu LC, Lohman RF, Gottlieb LJ, Franczyk M, Song DH (2005) Vacuum-assisted closure for sternal wounds: a first-line therapeutic management approach. Plast Reconstr Surg 116:1035–1040

    Article  CAS  PubMed  Google Scholar 

  • Anguita-Alonso P, Hanssen AD, Osmon DR, Trampuz A, Steckelberg JM, Patel R (2005) High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection. Clin Orthop Relat Res 439:43–47

    Article  PubMed  Google Scholar 

  • Antunes PE, Bernardo JE, Eugenio L, de Oliveira JF, Antunes MJ (1997) Mediastinitis after aorto-coronary bypass surgery. Eur J Cardiothorac Surg 12:443–449

    Article  CAS  PubMed  Google Scholar 

  • Aytaç S, Schnetzke M, Swartman B, Herrmann P, Woelfl C, Heppert V, Gruetzner PA, Guehring T (2014) Posttraumatic and postoperative osteomyelitis: surgical revision strategy with persisting fistula. Arch Orthop Trauma Surg 134:159–165

    Article  PubMed  Google Scholar 

  • Babouee Flury B, Elzi L, Kolbe M, Frei R, Weisser M, Scharen S, Widmer AF, Battegay M (2014) Is switching to an oral antibiotic regimen safe after 2 weeks of intravenous treatment for primary bacterial vertebral osteomyelitis? BMC Infect Dis 14:226

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Barrington NA (1988) The radiology of bone and joint infection. Br J Hosp Med 40:464–472

    CAS  PubMed  Google Scholar 

  • Becker K, Heilmann C, Peters G (2014) Coagulase-negative staphylococci. Clin Microbiol Rev 27:870–926

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Berbari EF, Kanj SS, Kowalski TJ, Darouiche RO, Widmer AF, Schmitt SK, Hendershot EF, Holtom PD, Huddleston PM III, Petermann GW, Osmon DR (2015) 2015 Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis 61:e26–e46

    Article  PubMed  Google Scholar 

  • Bernard A, Kermarrec G, Parize P, Caruba T, Bouvet A, Mainardi JL, Sabatier B, Nich C (2015a) Dramatic reduction of clindamycin serum concentration in staphylococcal osteoarticular infection patients treated with the oral clindamycin-rifampicin combination. J Infect 71:200–206

    Article  PubMed  Google Scholar 

  • Bernard L, Dinh A, Ghout I, Simo D, Zeller V, Issartel B, Le M, V, Belmatoug N, Lesprit P, Bru JP, Therby A, Bouhour D, Denes E, Debard A, Chirouze C, Fevre K, Dupon M, Aegerter P, Mulleman D (2015b) Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial. Lancet 385:875–882

    Google Scholar 

  • Bickels J, Ben-Sira L, Kessler A, Wientroub S (2002) Primary pyomyositis. J Bone Joint Surg Am 84-A:2277–2286

    Google Scholar 

  • Bischoff M, Dunman P, Kormanec J, Macapagal D, Murphy E, Mounts W, Berger-Bachi B, Projan S (2004) Microarray-based analysis of the Staphylococcus aureus sigmaB regulon. J Bacteriol 186:4085–4099

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blyth MJ, Kincaid R, Craigen MA, Bennet GC (2001) The changing epidemiology of acute and subacute haematogenous osteomyelitis in children. J Bone Joint Surg Br 83:99–102

    Article  CAS  PubMed  Google Scholar 

  • Boody BS, Jenkins TJ, Maslak J, Hsu WK, Patel AA (2015) Vertebral osteomyelitis and spinal epidural abscess: an evidence-based review. J Spinal Disord Tech 28:E316–E327

    Article  PubMed  Google Scholar 

  • Borger MA, Rao V, Weisel RD, Ivanov J, Cohen G, Scully HE, David TE (1998) Deep sternal wound infection: risk factors and outcomes. Ann Thorac Surg 65:1050–1056

    Article  CAS  PubMed  Google Scholar 

  • Breusch SJ, Kuhn KD (2003) Bone cements based on polymethylmethacrylate. Orthopade 32:41–50

    Article  CAS  PubMed  Google Scholar 

  • Buchholz HW, Elson RA, Engelbrecht E, Lodenkamper H, Rottger J, Siegel A (1981) Management of deep infection of total hip replacement. J Bone Joint Surg Br 63-B:342–353

    Google Scholar 

  • Campoccia D, Speziale P, Ravaioli S, Cangini I, Rindi S, Pirini V, Montanaro L, Arciola CR (2009) The presence of both bone sialoprotein-binding protein gene and collagen adhesin gene as a typical virulence trait of the major epidemic cluster in isolates from orthopedic implant infections. Biomaterials 30:6621–6628

    Article  CAS  PubMed  Google Scholar 

  • Caputo GM, Cavanagh PR, Ulbrecht JS, Gibbons GW, Karchmer AW (1994) Assessment and management of foot disease in patients with diabetes. N Engl J Med 331:854–860

    Article  CAS  PubMed  Google Scholar 

  • Carragee EJ (1997) The clinical use of magnetic resonance imaging in pyogenic vertebral osteomyelitis. Spine (Phila Pa 1976) 22:780–785

    Google Scholar 

  • Carragee EJ, Kim D, van der Vlugt T, Vittum D (1997) The clinical use of erythrocyte sedimentation rate in pyogenic vertebral osteomyelitis. Spine (Phila Pa 1976) 22:2089–2093

    Google Scholar 

  • Ceroni D, Cherkaoui A, Ferey S, Kaelin A, Schrenzel J (2010) Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new specific real-time PCR assay to the diagnosis. J Pediatr Orthop 30:301–304

    Article  PubMed  Google Scholar 

  • Chauhan S, Jain S, Varma S, Chauhan SS (2004) Tropical pyomyositis (myositis tropicans): current perspective. Postgrad Med J 80:267–270

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chiedozi LC (1979) Pyomyositis. Review of 205 cases in 112 patients. Am J Surg 137:255–259

    Article  CAS  PubMed  Google Scholar 

  • Christin L, Sarosi GA (1992) Pyomyositis in North America: case reports and review. Clin Infect Dis 15:668–677

    Article  CAS  PubMed  Google Scholar 

  • Ciampolini J, Harding KG (2000) Pathophysiology of chronic bacterial osteomyelitis. Why do antibiotics fail so often? Postgrad Med J 76:479–483

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clarke SR, Foster SJ (2006) Surface adhesins of Staphylococcus aureus. Adv Microb Physiol 51:187–224

    Article  CAS  PubMed  Google Scholar 

  • Clerc O, Prod’hom G, Greub G, Zanetti G, Senn L (2011) Adult native septic arthritis: a review of 10 years of experience and lessons for empirical antibiotic therapy. J Antimicrob Chemother 66:1168–1173

    Article  CAS  PubMed  Google Scholar 

  • Coakley G, Mathews C, Field M, Jones A, Kingsley G, Walker D, Phillips M, Bradish C, McLachlan A, Mohammed R, Weston V (2006) BSR & BHPR, BOA, RCGP and BSAC guidelines for management of the hot swollen joint in adults. Rheumatology (Oxford) 45:1039–1041

    Article  CAS  Google Scholar 

  • Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O, Meersseman W, Akova M, Arendrup MC, Arikan-Akdagli S, Bille J, Castagnola E, Cuenca-Estrella M, Donnelly JP, Groll AH, Herbrecht R, Hope WW, Jensen HE, Lass-Florl C, Petrikkos G, Richardson MD, Roilides E, Verweij PE, Viscoli C, Ullmann AJ (2012) ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect 18(Suppl 7):19–37

    Article  CAS  PubMed  Google Scholar 

  • Craigen MA, Watters J, Hackett JS (1992) The changing epidemiology of osteomyelitis in children. J Bone Joint Surg Br 74:541–545

    CAS  PubMed  Google Scholar 

  • Crum NF (2004) Bacterial pyomyositis in the United States. Am J Med 117:420–428

    Article  PubMed  Google Scholar 

  • Czekaj J, Dinh A, Moldovan A, Vaudaux P, Gras G, Hoffmeyer P, Lew D, Bernard L, Uckay I (2011) Efficacy of a combined oral clindamycin-rifampicin regimen for therapy of staphylococcal osteoarticular infections. Scand J Infect Dis 43:962–967

    Article  CAS  PubMed  Google Scholar 

  • Dartnell J, Ramachandran M, Katchburian M (2012) Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature. J Bone Joint Surg Br 94:584–595

    Article  CAS  PubMed  Google Scholar 

  • Davis JS (2005) Management of bone and joint infections due to Staphylococcus aureus. Intern Med J 35(Suppl 2):S79–S96

    Article  PubMed  Google Scholar 

  • Desandre AR, Cottone FJ, Evers ML (1995) Iliopsoas abscess: etiology, diagnosis, and treatment. Am Surg 61:1087–1091

    CAS  PubMed  Google Scholar 

  • Doss M, Martens S, Wood JP, Wolff JD, Baier C, Moritz A (2002) Vacuum-assisted suction drainage versus conventional treatment in the management of poststernotomy osteomyelitis. Eur J Cardiothorac Surg 22:934–938

    Article  PubMed  Google Scholar 

  • Dubost JJ, Fis I, Denis P, Lopitaux R, Soubrier M, Ristori JM, Bussiere JL, Sirot J, Sauvezie B (1993) Polyarticular septic arthritis. Medicine (Baltimore) 72:296–310

    Article  CAS  Google Scholar 

  • Dubost JJ, Soubrier M, De Champs C, Ristori JM, Bussiere JL, Sauvezie B (2002) No changes in the distribution of organisms responsible for septic arthritis over a 20 year period. Ann Rheum Dis 61:267–269

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • El Oakley RM, Wright JE (1996) Postoperative mediastinitis: classification and management. Ann Thorac Surg 61:1030–1036

    Article  PubMed  Google Scholar 

  • Elasri MO, Thomas JR, Skinner RA, Blevins JS, Beenken KE, Nelson CL, Smeltzer MS (2002) Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. Bone 30:275–280

    Article  CAS  PubMed  Google Scholar 

  • Ellington JK, Reilly SS, Ramp WK, Smeltzer MS, Kellam JF, Hudson MC (1999) Mechanisms of Staphylococcus aureus invasion of cultured osteoblasts. Microb Pathog 26:317–323

    Article  CAS  PubMed  Google Scholar 

  • Falagas ME, Rosmarakis ES (2006) Recurrent post-sternotomy mediastinitis. J Infect 52:e151–e154

    Article  PubMed  Google Scholar 

  • Fuchs T, Schmidmaier G, Raschke MJ, Stange R (2008) Bioactive-coated implants in trauma surgery. Eur J Trauma Emerg Surg 34:60–68

    Article  PubMed  Google Scholar 

  • Fuursted K, Arpi M, Lindblad BE, Pedersen LN (2008) Broad-range PCR as a supplement to culture for detection of bacterial pathogens in patients with a clinically diagnosed spinal infection. Scand J Infect Dis 40:772–777

    Article  CAS  PubMed  Google Scholar 

  • Garzoni C, Kelley WL (2009) Staphylococcus aureus: new evidence for intracellular persistence. Trends Microbiol 17:59–65

    Article  CAS  PubMed  Google Scholar 

  • Gasbarrini AL, Bertoldi E, Mazzetti M, Fini L, Terzi S, Gonella F, Mirabile L, Barbanti BG, Furno A, Gasbarrini A, Boriani S (2005) Clinical features, diagnostic and therapeutic approaches to haematogenous vertebral osteomyelitis. Eur Rev Med Pharmacol Sci 9:53–66

    CAS  PubMed  Google Scholar 

  • Gold RH, Hawkins RA, Katz RD (1991) Bacterial osteomyelitis: findings on plain radiography, CT, MR, and scintigraphy. AJR Am J Roentgenol 157:365–370

    Article  CAS  PubMed  Google Scholar 

  • Goldenberg DL (1998) Septic arthritis. Lancet 351:197–202

    Article  CAS  PubMed  Google Scholar 

  • Goldenberg DL, Reed JI (1985) Bacterial arthritis. N Engl J Med 312:764–771

    Article  CAS  PubMed  Google Scholar 

  • Gordon BA, Martinez S, Collins AJ (1995) Pyomyositis: characteristics at CT and MR imaging. Radiology 197:279–286

    Article  CAS  PubMed  Google Scholar 

  • Grammatico L, Baron S, Rusch E, Lepage B, Surer N, Desenclos JC, Besnier JM (2008) Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002–2003. Epidemiol Infect 136:653–660

    Article  CAS  PubMed  Google Scholar 

  • Gross T, Kaim AH, Regazzoni P, Widmer AF (2002) Current concepts in posttraumatic osteomyelitis: a diagnostic challenge with new imaging options. J Trauma 52:1210–1219

    Article  PubMed  Google Scholar 

  • Grossi EA, Culliford AT, Krieger KH, Kloth D, Press R, Baumann FG, Spencer FC (1985) A survey of 77 major infectious complications of median sternotomy: a review of 7,949 consecutive operative procedures. Ann Thorac Surg 40:214–223

    Article  CAS  PubMed  Google Scholar 

  • Gummert JF, Barten MJ, Hans C, Kluge M, Doll N, Walther T, Hentschel B, Schmitt DV, Mohr FW, Diegeler A (2002) Mediastinitis and cardiac surgery—an updated risk factor analysis in 10,373 consecutive adult patients. Thorac Cardiovasc Surg 50:87–91

    Article  CAS  PubMed  Google Scholar 

  • Gupta MN, Sturrock RD, Field M (2001) A prospective 2-year study of 75 patients with adult-onset septic arthritis. Rheumatology (Oxford) 40:24–30

    Article  CAS  Google Scholar 

  • Gupta A, Kowalski TJ, Osmon DR, Enzler M, Steckelberg JM, Huddleston PM, Nassr A, Mandrekar JM, Berbari EF (2014) Long-term outcome of pyogenic vertebral osteomyelitis: a cohort study of 260 patients. Open Forum Infect Dis 1:ofu107

    Google Scholar 

  • Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F., Dulgheru R, El KG, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos MP, Vilacosta I, Zamorano JL (2015) 2015 ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC) endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 36:3075–3128

    Google Scholar 

  • Hariharan P, Kabrhel C (2011) Sensitivity of erythrocyte sedimentation rate and C-reactive protein for the exclusion of septic arthritis in emergency department patients. J Emerg Med 40:428–431

    Article  PubMed  Google Scholar 

  • Haslinger-Löffler B, Kahl BC, Grundmeier M, Strangfeld K, Wagner B, Fischer U, Cheung AL, Peters G, Schulze-Osthoff K, Sinha B (2005) Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. Cell Microbiol 7:1087–1097

    Article  PubMed  CAS  Google Scholar 

  • Henke PK, Blackburn SA, Wainess RW, Cowan J, Terando A, Proctor M, Wakefield TW, Upchurch GR Jr, Stanley JC, Greenfield LJ (2005) Osteomyelitis of the foot and toe in adults is a surgical disease: conservative management worsens lower extremity salvage. Ann Surg 241:885–892

    Article  PubMed  PubMed Central  Google Scholar 

  • Hersh RE, Jack JM, Dahman MI, Morgan RF, Drake DB (2001) The vacuum-assisted closure device as a bridge to sternal wound closure. Ann Plast Surg 46:250–254

    Article  CAS  PubMed  Google Scholar 

  • Horst SA, Hoerr V, Beineke A, Kreis C, Tuchscherr L, Kalinka J, Lehne S, Schleicher I, Köhler G, Fuchs T, Raschke MJ, Rohde M, Peters G, Faber C, Löffler B, Medina E (2012) A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis. Am J Pathol 181:1206–1214

    Article  PubMed  Google Scholar 

  • Howard AW, Viskontas D, Sabbagh C (1999) Reduction in osteomyelitis and septic arthritis related to Haemophilus influenzae type B vaccination. J Pediatr Orthop 19:705–709

    CAS  PubMed  Google Scholar 

  • Howard-Jones AR, Isaacs D (2010) Systematic review of systemic antibiotic treatment for children with chronic and sub-acute pyogenic osteomyelitis. J Paediatr Child Health 46:736–741

    Article  PubMed  Google Scholar 

  • Hsueh PR, Hsiue TR, Hsieh WC (1996) Pyomyositis in intravenous drug abusers: report of a unique case and review of the literature. Clin Infect Dis 22:858–860

    Article  CAS  PubMed  Google Scholar 

  • Hughes JG, Vetter EA, Patel R, Schleck CD, Harmsen S, Turgeant LT, Cockerill FR III (2001) Culture with BACTEC Peds Plus/F bottle compared with conventional methods for detection of bacteria in synovial fluid. J Clin Microbiol 39:4468–4471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Idusuyi OB (2015) Surgical management of Charcot neuroarthropathy. Prosthet Orthot Int 39:61–72

    Article  PubMed  Google Scholar 

  • Jagodzinski NA, Kanwar R, Graham K, Bache CE (2009) Prospective evaluation of a shortened regimen of treatment for acute osteomyelitis and septic arthritis in children. J Pediatr Orthop 29:518–525

    Article  PubMed  Google Scholar 

  • Jaramillo D (2011) Infection: musculoskeletal. Pediatr Radiol 41(Suppl 1):S127–S134

    Article  PubMed  Google Scholar 

  • Join-Lambert O, Ribadeau-Dumas F, Jullien V, Kitzis MD, Jais JP, Coignard-Biehler H, Guet-Revillet H, Consigny PH, Delage M, Nassif X, Lortholary O, Nassif A (2014) Dramatic reduction of clindamycin plasma concentration in hidradenitis suppurativa patients treated with the rifampin-clindamycin combination. Eur J Dermatol 24:94–95

    CAS  PubMed  Google Scholar 

  • Julian OC, Lopez-Belio M, Dye WS, Javid H, Grove WJ (1957) The median sternal incision in intracardiac surgery with extracorporeal circulation; a general evaluation of its use in heart surgery. Surgery 42:753–761

    CAS  PubMed  Google Scholar 

  • Jurkiewicz MJ, Bostwick J III, Hester TR, Bishop JB, Craver J (1980) Infected median sternotomy wound. Successful treatment by muscle flaps. Ann Surg 191:738–744

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaandorp CJ, van Schaardenburg D, Krijnen P, Habbema JD, van de Laar MA (1995) Risk factors for septic arthritis in patients with joint disease. A prospective study. Arthritis Rheum 38:1819–1825

    Article  CAS  PubMed  Google Scholar 

  • Kaandorp CJ, Dinant HJ, van de Laar MA, Moens HJ, Prins AP, Dijkmans BA (1997a) Incidence and sources of native and prosthetic joint infection: a community based prospective survey. Ann Rheum Dis 56:470–475

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaandorp CJ, Krijnen P, Moens HJ, Habbema JD, van SD (1997b) The outcome of bacterial arthritis: a prospective community-based study. Arthritis Rheum 40:884–892

    Google Scholar 

  • Kalinka J, Hachmeister M, Geraci J, Sordelli D, Hansen U, Niemann S, Oetermann S, Peters G, Löffler B, Tuchscherr L (2014) Staphylococcus aureus isolates from chronic osteomyelitis are characterized by high host cell invasion and intracellular adaptation, but still induce inflammation. Int J Med Microbiol 304:1038–1049

    Article  PubMed  Google Scholar 

  • Kim H, Kim J, Ihm C (2010) The usefulness of multiplex PCR for the identification of bacteria in joint infection. J Clin Lab Anal 24:175–181

    Article  CAS  PubMed  Google Scholar 

  • Kim CJ, Song KH, Park WB, Kim ES, Park SW, Kim HB, Oh MD, Kim NJ (2012) Microbiologically and clinically diagnosed vertebral osteomyelitis: impact of prior antibiotic exposure. Antimicrob Agents Chemother 56:2122–2124

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Klesius AA, Dzemali O, Simon A, Kleine P, Abdel-Rahman U, Herzog C, Wimmer-Greinecker G, Moritz A (2004) Successful treatment of deep sternal infections following open heart surgery by bilateral pectoralis major flaps. Eur J Cardiothorac Surg 25:218–223

    Article  PubMed  Google Scholar 

  • Kortekangas P, Aro HT, Lehtonen OP (1995) Synovial fluid culture and blood culture in acute arthritis. A multi-case report of 90 patients. Scand J Rheumatol 24:44–47

    Article  CAS  PubMed  Google Scholar 

  • Kowalski TJ, Berbari EF, Huddleston PM, Steckelberg JM, Osmon DR (2006) Do follow-up imaging examinations provide useful prognostic information in patients with spine infection? Clin Infect Dis 43:172–179

    Article  PubMed  Google Scholar 

  • Kriegeskorte A, König S, Sander G, Pirkl A, Mahabir E, Proctor RA, von Eiff C, Peters G, Becker K (2011) Small colony variants of Staphylococcus aureus reveal distinct protein profiles. Proteomics 11:2476–2490

    Article  CAS  PubMed  Google Scholar 

  • Levin MJ, Gardner P, Waldvogel FA (1971) Tropical pyomyositis—an unusual infection due to staphylococcus aureus. N Engl J Med 284:196–198

    Article  CAS  PubMed  Google Scholar 

  • Lew DP, Waldvogel FA (2004) Osteomyelitis. Lancet 364:369–379

    Article  CAS  PubMed  Google Scholar 

  • Loop FD, Lytle BW, Cosgrove DM, Mahfood S, McHenry MC, Goormastic M, Stewart RW, Golding LA, Taylor PC (1990) Sternal wound complications after isolated coronary artery bypass grafting: early and late mortality, morbidity, and cost of care. Ann Thorac Surg 49:179–186

    Article  CAS  PubMed  Google Scholar 

  • Losanoff JE, Richman BW, Jones JW (2002) Disruption and infection of median sternotomy: a comprehensive review. Eur J Cardiothorac Surg 21:831–839

    Article  PubMed  Google Scholar 

  • Love C, Palestro CJ (2016) Nuclear medicine imaging of bone infections. Clin Radiol

    Google Scholar 

  • Mader JT, Shirtliff M, Calhoun JH (1997) Staging and staging application in osteomyelitis. Clin Infect Dis 25:1303–1309

    Article  CAS  PubMed  Google Scholar 

  • Malcius D, Trumpulyte G, Barauskas V, Kilda A (2005) Two decades of acute hematogenous osteomyelitis in children: are there any changes? Pediatr Surg Int 21:356–359

    Article  CAS  PubMed  Google Scholar 

  • Malizos K, Sarma J, Seaton RA, Militz M, Menichetti F, Riccio G, Gaudias J, Trostmann U, Pathan R, Hamed K (2016) Daptomycin for the treatment of osteomyelitis and orthopaedic device infections: real-world clinical experience from a European registry. Eur J Clin Microbiol Infect Dis 35:111–118

    Article  CAS  PubMed  Google Scholar 

  • Margaretten ME, Kohlwes J, Moore D, Bent S (2007) Does this adult patient have septic arthritis? JAMA 297:1478–1488

    Article  CAS  PubMed  Google Scholar 

  • Marschall J, Bhavan KP, Olsen MA, Fraser VJ, Wright NM, Warren DK (2011) The impact of prebiopsy antibiotics on pathogen recovery in hematogenous vertebral osteomyelitis. Clin Infect Dis 52:867–872

    Article  PubMed  PubMed Central  Google Scholar 

  • Masquelet AC, Begue T (2010) The concept of induced membrane for reconstruction of long bone defects. Orthop Clin North Am 41:27–37

    Article  PubMed  Google Scholar 

  • Mathews CJ, Weston VC, Jones A, Field M, Coakley G (2010) Bacterial septic arthritis in adults. Lancet 375:846–855

    Article  PubMed  Google Scholar 

  • McHenry MC, Easley KA, Locker GA (2002) Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis 34:1342–1350

    Article  PubMed  Google Scholar 

  • McKee MD, Wild LM, Schemitsch EH, Waddell JP (2002) The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma 16:622–627

    Article  PubMed  Google Scholar 

  • McKee MD, Li-Bland EA, Wild LM, Schemitsch EH (2010) A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma 24:483–490

    Article  PubMed  Google Scholar 

  • Merritt K (1988) Factors increasing the risk of infection in patients with open fractures. J Trauma 28:823–827

    Article  CAS  PubMed  Google Scholar 

  • Milano CA, Georgiade G, Muhlbaier LH, Smith PK, Wolfe WG (1999) Comparison of omental and pectoralis flaps for poststernotomy mediastinitis. Ann Thorac Surg 67:377–380

    Article  CAS  PubMed  Google Scholar 

  • Mitchell G, Fugere A, Pepin Gaudreau K, Brouillette E, Frost EH, Cantin AM, Malouin F (2013) SigB is a dominant regulator of virulence in Staphylococcus aureus small-colony variants. PLoS ONE 8:e65018

    Article  PubMed  PubMed Central  Google Scholar 

  • Miyake H (1904) Beitrag zur Kenntniss des sogenannten Myositis infectiosa. Mitt Grenzgeb Med Chir 13:145–198

    Google Scholar 

  • Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A (2009) Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum 39:10–17

    Article  CAS  PubMed  Google Scholar 

  • Nahai F, Rand RP, Hester TR, Bostwick J III, Jurkiewicz MJ (1989) Primary treatment of the infected sternotomy wound with muscle flaps: a review of 211 consecutive cases. Plast Reconstr Surg 84:434–441

    Article  CAS  PubMed  Google Scholar 

  • Neut D, Kluin OS, Crielaard BJ, van der Mei HC, Busscher HJ, Grijpma DW (2009) A biodegradable antibiotic delivery system based on poly-(trimethylene carbonate) for the treatment of osteomyelitis. Acta Orthop 80:514–519

    Article  PubMed  PubMed Central  Google Scholar 

  • Novick R (2000) Pathogenicity factors and their regulation. In: Fischetti VA (ed) Gram-positive pathogens. American Society of Microbiology, Washington, D.C., pp 392–407

    Google Scholar 

  • Novick RP (2003) Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 48:1429–1449

    Article  CAS  PubMed  Google Scholar 

  • Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR (2013) Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 56:e1–e25

    Article  PubMed  Google Scholar 

  • Otto M (2009) Staphylococcus epidermidis—the ‘accidental’ pathogen. Nat Rev Microbiol 7:555–567

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Otto MP, Martin E, Badiou C, Lebrun S, Bes M, Vandenesch F, Etienne J, Lina G, Dumitrescu O (2013) Effects of subinhibitory concentrations of antibiotics on virulence factor expression by community-acquired methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 68:1524–1532

    Article  CAS  PubMed  Google Scholar 

  • Parsons B, Strauss E (2004) Surgical management of chronic osteomyelitis. Am J Surg 188:57–66

    Article  PubMed  Google Scholar 

  • Patzakis MJ, Wilkins J (1989) Factors influencing infection rate in open fracture wounds. Clin Orthop Relat Res 36–40

    Google Scholar 

  • Peltola H, Pääkkönen M (2014) Acute osteomyelitis in children. N Engl J Med 370:352–360

    Article  CAS  PubMed  Google Scholar 

  • Peltola H, Pääkkönen M, Kallio P, Kallio MJ (2010) Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: prospective, randomized trial on 131 culture-positive cases. Pediatr Infect Dis J 29:1123–1128

    Article  PubMed  Google Scholar 

  • Peterson TC, Pearson C, Zekaj M, Hudson I, Fakhouri G, Vaidya R (2014) Septic arthritis in intravenous drug abusers: a historical comparison of habits and pathogens. J Emerg Med 47:723–728

    Article  PubMed  Google Scholar 

  • Pfeifer R, Kobbe P, Knobe M, Pape HC (2011) The reamer-irrigator-aspirator (RIA) system. Oper Orthop Traumatol 23:446–452

    Article  CAS  PubMed  Google Scholar 

  • Pigrau C, Almirante B, Flores X, Falco V, Rodriguez D, Gasser I, Villanueva C, Pahissa A (2005) Spontaneous pyogenic vertebral osteomyelitis and endocarditis: incidence, risk factors, and outcome. Am J Med 118:1287

    Article  PubMed  Google Scholar 

  • Proctor RA, van Langevelde P, Kristjansson M, Maslow JN, Arbeit RD (1995) Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus. Clin Infect Dis 20:95–102

    Article  CAS  PubMed  Google Scholar 

  • Proctor RA, von Eiff C, Kahl BC, Becker K, McNamara P, Herrmann M, Peters G (2006) Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol 4:295–305

    Article  CAS  PubMed  Google Scholar 

  • Raschke MJ, Schmidmaier G (2004) Biological coating of implants in trauma and orthopedic surgery. Unfallchirurg 107:653–663

    CAS  PubMed  Google Scholar 

  • Rasigade JP, Trouillet-Assant S, Ferry T, Diep BA, Sapin A, Lhoste Y, Ranfaing J, Badiou C, Benito Y, Bes M, Couzon F, Tigaud S, Lina G, Etienne J, Vandenesch F, Laurent F (2013) PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts. PLoS ONE 8:e63176

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Reichert P, Rutowski R, Zimmer K, Gosk J (2007) Application of gentamycini impregnated polymethylmethacrylate (PMMA) (Septopal) in treatment of infected nonunion. Own experiments. Polim Med 37:65–72

    PubMed  Google Scholar 

  • Ricci MA, Rose FB, Meyer KK (1986) Pyogenic psoas abscess: worldwide variations in etiology. World J Surg 10:834–843

    Article  CAS  PubMed  Google Scholar 

  • Riise OR, Kirkhus E, Handeland KS, Flato B, Reiseter T, Cvancarova M, Nakstad B, Wathne KO (2008) Childhood osteomyelitis-incidence and differentiation from other acute onset musculoskeletal features in a population-based study. BMC Pediatr 8:45

    Article  PubMed  PubMed Central  Google Scholar 

  • Ringelman PR, Vander Kolk CA, Cameron D, Baumgartner WA, Manson PN (1994) Long-term results of flap reconstruction in median sternotomy wound infections. Plast Reconstr Surg 93:1208–1214

    Article  CAS  PubMed  Google Scholar 

  • Robicsek F, Daugherty HK, Cook JW (1977) The prevention and treatment of sternum separation following open-heart surgery. J Thorac Cardiovasc Surg 73:267–268

    CAS  PubMed  Google Scholar 

  • Roblot F, Besnier JM, Juhel L, Vidal C, Ragot S, Bastides F, Le MG, Godet C, Mulleman D, Azais I, Becq-Giraudon B, Choutet P (2007) Optimal duration of antibiotic therapy in vertebral osteomyelitis. Semin Arthritis Rheum 36:269–277

    Article  CAS  PubMed  Google Scholar 

  • Rodgers WB, Yodlowski ML, Mintzer CM (1993) Pyomyositis in patients who have the human immunodeficiency virus. Case report and review of the literature. J Bone Joint Surg Am 75:588–592

    Article  CAS  PubMed  Google Scholar 

  • Roux S, Valour F, Karsenty J, Gagnieu MC, Perpoint T, Lustig S, Ader F, Martha B, Laurent F, Chidiac C, Ferry T (2016) Daptomycin >6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center. BMC Infect Dis 16:83

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rybak MJ, Lomaestro BM, Rotschafer JC, Moellering RC, Craig WA, Billeter M, Dalovisio JR, Levine DP (2009) Vancomycin therapeutic guidelines: a summary of consensus recommendations from the Infectious Diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. Clin Infect Dis 49:325–327

    Article  PubMed  Google Scholar 

  • Salar O, Baker B, Kurien T, Taylor A, Moran C (2014) Septic arthritis in the era of immunosuppressive treatments. Ann R Coll Surg Engl 96:e11–e12

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schaumburg F, Peters G, Alabi A, Becker K, Idelevich EA (2016) Missense mutations of PBP2a are associated with reduced susceptibility to ceftaroline and ceftobiprole in African MRSA. J Antimicrob Chemother 71:41–44

    Article  CAS  PubMed  Google Scholar 

  • Schmidmaier G, Lucke M, Wildemann B, Haas NP, Raschke M (2006) Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review. Injury 37(Suppl 2):S105–S112

    Article  PubMed  Google Scholar 

  • Schrenzel J, Harbarth S, Schockmel G, Genne D, Bregenzer T, Flueckiger U, Petignat C, Jacobs F, Francioli P, Zimmerli W, Lew DP (2004) A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection. Clin Infect Dis 39:1285–1292

    Article  CAS  PubMed  Google Scholar 

  • Seaton RA, Menichetti F, Dalekos G, Beiras-Fernandez A, Nacinovich F, Pathan R, Hamed K (2015) Evaluation of effectiveness and safety of high-dose daptomycin: results from patients included in the European Cubicin® outcomes registry and experience. Adv Ther 32:1192–1205

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sehn JK, Gilula LA (2012) Percutaneous needle biopsy in diagnosis and identification of causative organisms in cases of suspected vertebral osteomyelitis. Eur J Radiol 81:940–946

    Article  PubMed  Google Scholar 

  • Sendi P, Zimmerli W (2012) Antimicrobial treatment concepts for orthopaedic device-related infection. Clin Microbiol Infect 18:1176–1184

    Article  CAS  PubMed  Google Scholar 

  • Shields D, Robinson P, Crowley TP (2012) Iliopsoas abscess—a review and update on the literature. Int J Surg 10:466–469

    Article  CAS  PubMed  Google Scholar 

  • Shirtliff ME, Mader JT (2002) Acute septic arthritis. Clin Microbiol Rev 15:527–544

    Article  PubMed  PubMed Central  Google Scholar 

  • Shmerling RH, Delbanco TL, Tosteson AN, Trentham DE (1990) Synovial fluid tests. What should be ordered? JAMA 264:1009–1014

    Article  CAS  PubMed  Google Scholar 

  • Sinha B, Francois PP, Nusse O, Foti M, Hartford OM, Vaudaux P, Foster TJ, Lew DP, Herrmann M, Krause KH (1999) Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1. Cell Microbiol 1:101–117

    Article  CAS  PubMed  Google Scholar 

  • Stengel D, Bauwens K, Sehouli J, Ekkernkamp A, Porzsolt F (2001) Systematic review and meta-analysis of antibiotic therapy for bone and joint infections. Lancet Infect Dis 1:175–188

    Article  CAS  PubMed  Google Scholar 

  • Strommenger B, Layer F, Klare I, Werner G (2015) Pre-use susceptibility to ceftaroline in clinical Staphylococcus aureus isolates from Germany: is there a non-susceptible pool to be selected? PLoS ONE 10:e0125864

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tande AJ, Patel R (2014) Prosthetic joint infection. Clin Microbiol Rev 27:302–345

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tebartz C, Horst SA, Sparwasser T, Huehn J, Beineke A, Peters G, Medina E (2015) A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection. J Immunol 194:1100–1111

    Article  CAS  PubMed  Google Scholar 

  • Tegnell A, Arén C, Öhman L (2000) Coagulase-negative staphylococci and sternal infections after cardiac operation. Ann Thorac Surg 69:1104–1109

    Article  CAS  PubMed  Google Scholar 

  • Tice AD, Hoaglund PA, Shoultz DA (2003) Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy. Am J Med 114:723–728

    Article  CAS  PubMed  Google Scholar 

  • Torda AJ, Gottlieb T, Bradbury R (1995) Pyogenic vertebral osteomyelitis: analysis of 20 cases and review. Clin Infect Dis 20:320–328

    Article  CAS  PubMed  Google Scholar 

  • Trampuz A, Zimmerli W (2006a) Antimicrobial agents in orthopaedic surgery: prophylaxis and treatment. Drugs 66:1089–1105

    Article  CAS  PubMed  Google Scholar 

  • Trampuz A, Zimmerli W (2006b) Diagnosis and treatment of infections associated with fracture-fixation devices. Injury 37(Suppl 2):S59–S66

    Article  PubMed  Google Scholar 

  • Tuchscherr L, Löffler B (2016) Staphylococcus aureus dynamically adapts global regulators and virulence factor expression in the course from acute to chronic infection. Curr Genet 62:15–17

    Article  CAS  PubMed  Google Scholar 

  • Tuchscherr L, Heitmann V, Hussain M, Viemann D, Roth J, von Eiff C, Peters G, Becker K, Löffler B (2010) Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence. J Infect Dis 202:1031–1040

    Article  PubMed  Google Scholar 

  • Tuchscherr L, Medina E, Hussain M, Volker W, Heitmann V, Niemann S, Holzinger D, Roth J, Proctor RA, Becker K, Peters G, Löffler B (2011) Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection. EMBO Mol Med 3:129–141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tuchscherr L, Bischoff M, Lattar SM, Noto Llana M, Pförtner H, Niemann S, Geraci J, Van de Vyver H, Fraunholz MJ, Cheung AL, Herrmann M, Völker U, Sordelli DO, Peters G, Löffler B (2015) Sigma factor SigB is crucial to mediate Staphylococcus aureus adaptation during chronic infections. PLoS Pathog 11:e1004870

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tuchscherr L, Kreis CA, Hoerr V, Flint L, Hachmeister M, Geraci J, Bremer-Streck S, Kiehntopf M, Medina E, Kribus M, Raschke M, Pletz M, Peters G, Loffler B (2016) Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis. J Antimicrob Chemother 71:438–448

    Article  CAS  PubMed  Google Scholar 

  • Tung H, Guss B, Hellman U, Persson L, Rubin K, Ryden C (2000) A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family. Biochem J 345(Pt 3):611–619

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uckay I, Gariani K, Pataky Z, Lipsky BA (2014) Diabetic foot infections: state-of-the-art. Diabetes Obes Metab 16:305–316

    Article  CAS  PubMed  Google Scholar 

  • Uckay I, Aragon-Sanchez J, Lew D, Lipsky BA (2015) Diabetic foot infections: what have we learned in the last 30 years? Int J Infect Dis 40:81–91

    Google Scholar 

  • Valour F, Rasigade JP, Trouillet-Assant S, Gagnaire J, Bouaziz A, Karsenty J, Lacour C, Bes M, Lustig S, Benet T, Chidiac C, Etienne J, Vandenesch F, Ferry T, Laurent F (2015) Delta-toxin production deficiency in Staphylococcus aureus: a diagnostic marker of bone and joint infection chronicity linked with osteoblast invasion and biofilm formation. Clin Microbiol Infect 21:568

    Article  PubMed  CAS  Google Scholar 

  • Van Bambeke F, Barcia-Macay M, Lemaire S, Tulkens PM (2006) Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives. Curr Opin Drug Discov Devel 9:218–230

    PubMed  Google Scholar 

  • Venkatesan K (1992) Pharmacokinetic drug interactions with rifampicin. Clin Pharmacokinet 22:47–65

    Article  CAS  PubMed  Google Scholar 

  • Viale P, Furlanut M, Scudeller L, Pavan F, Negri C, Crapis M, Zamparini E, Zuiani C, Cristini F, Pea F (2009) Treatment of pyogenic (non-tuberculous) spondylodiscitis with tailored high-dose levofloxacin plus rifampicin. Int J Antimicrob Agents 33:379–382

    Article  CAS  PubMed  Google Scholar 

  • von Eiff C, Bettin D, Proctor RA, Rolauffs B, Lindner N, Winkelmann W, Peters G (1997a) Recovery of small colony variants of Staphylococcus aureus following gentamicin bead placement for osteomyelitis. Clin Infect Dis 25:1250–1251

    Article  Google Scholar 

  • von Eiff C, Heilmann C, Proctor RA, Woltz C, Peters G, Götz F (1997b) A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly. J Bacteriol 179:4706–4712

    Article  Google Scholar 

  • von Eiff C, Becker K, Machka K, Stammer H, Peters G (2001) Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 344:11–16

    Article  Google Scholar 

  • Wagner FW Jr (1981) The dysvascular foot: a system for diagnosis and treatment. Foot Ankle 2:64–122

    Article  PubMed  Google Scholar 

  • Waldvogel FA, Medoff G, Swartz MN (1970a) Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. N Engl J Med 282:198–206

    Article  CAS  PubMed  Google Scholar 

  • Waldvogel FA, Medoff G, Swartz MN (1970b) Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. 3. Osteomyelitis associated with vascular insufficiency. N Engl J Med 282:316–322

    Article  CAS  PubMed  Google Scholar 

  • Weston VC, Jones AC, Bradbury N, Fawthrop F, Doherty M (1999) Clinical features and outcome of septic arthritis in a single UK Health District 1982–1991. Ann Rheum Dis 58:214–219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wright JA, Nair SP (2010) Interaction of staphylococci with bone. Int J Med Microbiol 300:193–204

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zieger MM, Dorr U, Schulz RD (1987) Ultrasonography of hip joint effusions. Skeletal Radiol 16:607–611

    Article  CAS  PubMed  Google Scholar 

  • Ziegler C, Goldmann O, Hobeika E, Geffers R, Peters G, Medina E (2011) The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy. EMBO Mol Med 3:652–666

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zimmerli W (2010) Vertebral osteomyelitis. N Engl J Med 362:1022–1029

    Article  CAS  PubMed  Google Scholar 

  • Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE (1998) Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) study group. JAMA 279:1537–1541

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Medical Microbiology, University Hospital Münster, 48149, Münster, Germany

    Evgeny A. Idelevich & Georg Peters

  2. Department of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany

    Carolin Kreis

  3. Institute of Medical Microbiology, Jena University Hospital, Jena, Germany

    Bettina Löffler

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  1. Evgeny A. Idelevich
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  2. Carolin Kreis
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  3. Bettina Löffler
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  4. Georg Peters
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Correspondence to Georg Peters .

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  1. GSK Vaccines, Siena, Italy

    Fabio Bagnoli

  2. GSK Vaccines, Siena, Italy

    Rino Rappuoli

  3. Center for Integrative Biology (CIBIO), University of Trento, Trento, Italy

    Guido Grandi

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Idelevich, E.A., Kreis, C., Löffler, B., Peters, G. (2016). Staphylococcus aureus-Associated Musculoskeletal Infections. In: Bagnoli, F., Rappuoli, R., Grandi, G. (eds) Staphylococcus aureus. Current Topics in Microbiology and Immunology, vol 409. Springer, Cham. https://doi.org/10.1007/82_2016_19

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