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Maturation of Corticolimbic Functional Connectivity During Sensitive Periods of Brain Development

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Sensitive Periods of Brain Development and Preventive Interventions

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 53))

Abstract

The maturation of key corticolimbic structures and the prefrontal cortex during sensitive periods of brain development from early life through adolescence is crucial for the acquisition of a variety of cognitive and affective processes associated with adult behavior. In this chapter, we first review how key cellular and circuit level changes during adolescence dictate the development of the prefrontal cortex and its capacity to integrate contextual and emotional information from the ventral hippocampus and the amygdala. We further discuss how afferent transmission from ventral hippocampal and amygdala inputs displays unique age-dependent trajectories that directly impact prefrontal functional maturation through adolescence. We conclude by proposing that time-sensitive strengthening of specific corticolimbic synapses is a critical contributing factor for the protracted maturation of cognitive and emotional regulation by the prefrontal cortex.

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Acknowledgements

Grant Sponsor: National Institute of Mental Health grants MH086507, MH105488, and MH123147 to KYT, and MH116475 to SY and KYT. The funding source had no role in the study design, data analysis, or writing of this report.

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Authors and Affiliations

  1. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

    Shaolin Yang

  2. Department of Anatomy and Cell Biology, University of Illinois at Chicago – College of Medicine, Chicago, IL, USA

    Kuei Y. Tseng

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  1. Shaolin Yang
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  2. Kuei Y. Tseng
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Correspondence to Kuei Y. Tseng .

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  1. Harvard Medical School, McLean Hospital, Belmont, MA, USA

    Susan L. Andersen

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Yang, S., Tseng, K.Y. (2021). Maturation of Corticolimbic Functional Connectivity During Sensitive Periods of Brain Development. In: Andersen, S.L. (eds) Sensitive Periods of Brain Development and Preventive Interventions. Current Topics in Behavioral Neurosciences, vol 53. Springer, Cham. https://doi.org/10.1007/7854_2021_239

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