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Clinical and Pathological Features of Parkinson’s Disease

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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 22))

Abstract

Parkinson’s disease (PD) is, after Alzheimer’s disease, the second most common neurodegenerative disorder with an approximate prevalence of 0.5–1 % among persons 65–69 years of age, rising to 1–3 % among persons 80 years of age and older. Pathologically, PD is characterized by the loss of neurons in the substantia nigra pars compacta (SNpc), and by the presence of eosinophilic protein deposits (Lewy bodies) in this region, in other aminergic nuclei and in cortical and limbic structures. Moreover, it has now been shown that pathology also involves the peripheral nervous system. Braak and colleagues suggested a thread of pathology starting from the vagal nerve to progress to the brainstem, and eventually to limbic and neocortical brain regions. This progression of pathology may account for the clinical evolution of PD toward a composite symptomatology. However, this hypothesis has been criticized by others. In this chapter, we review the clinical features of PD (motor and nonmotor) and their pathological correlates.

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Authors and Affiliations

  1. University of Kiel, Kiel, Germany

    Susanne A. Schneider

  2. Department of Neurology and Neuroscience, Medical School, Clinica Universitaria and CIMA, University of Navarra and CIBERNED, Pamplona, Spain

    Jose A. Obeso

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  1. Susanne A. Schneider
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  2. Jose A. Obeso
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Correspondence to Susanne A. Schneider .

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Editors and Affiliations

  1. Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tübingen, Germany

    Hoa Huu Phuc Nguyen

  2. Dept of Experimental Medical Science, Lund University, Lund, Sweden

    M. Angela Cenci

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Schneider, S.A., Obeso, J.A. (2014). Clinical and Pathological Features of Parkinson’s Disease. In: Nguyen, H., Cenci, M. (eds) Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease. Current Topics in Behavioral Neurosciences, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_317

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