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HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway

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Heat Shock Proteins in Human Diseases

Part of the book series: Heat Shock Proteins ((HESP,volume 21))

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Abbreviations

CDK2:

cyclin dependent kinase 2

DHRS2:

dehydrogenase/reductase 2

DOX:

doxycycline

HDF:

human diploid fibroblast

HDIS:

HSF1 depletion-induced cellular senescence

HSF1:

heat shock transcription factor 1

Hsp:

heat shock protein

Mieap:

mitochondria-eating protein

NAMPT:

nicotinamide phosphoribosyltransferase

PGC1α:

peroxisome proliferator-activated receptor γ coactivator-1α

ROS:

reactive oxygen species

SASP:

senescence-associated secretory phenotype

SA-β-gal:

senescence-associated β-galactosidase

shRNA:

short-hairpin RNA

SDR:

short-chain NAD/NADP-dependent dehydrogenase/reductase

TERT:

telomerase reverse transcriptase

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Acknowledgements

I am grateful to members of my laboratory (Tsukasa Oda, Takayuki Sekimoto and Kiminori Kurashima) for their crucial contribution to this work, and to Mitsuaki Fujimoto and Akira Nakai for their collaboration. I thank Jeremy Allen, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. This study was funded by Japan Society for the Promotion of Science (KAKENHI, Grant Number JP15K06866). Financial support was also provided by the Takeda Science Foundation and the Osaka Cancer Research Foundation.

Disclosure of Interests

The author declares he has no conflict of interest.

Ethical Approval for Studies Involving Humans

This article does not contain any studies with human participants performed by any of the authors.

Ethical Approval for Studies Involving Animals

This article does not contain any studies with animals performed by any of the authors.

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Authors and Affiliations

  1. Laboratory of Molecular Genetics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

    Takayuki Yamashita

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  1. Takayuki Yamashita
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Correspondence to Takayuki Yamashita .

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Editors and Affiliations

  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Punit Kaur

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Yamashita, T. (2020). HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway. In: Asea, A.A.A., Kaur, P. (eds) Heat Shock Proteins in Human Diseases. Heat Shock Proteins, vol 21. Springer, Cham. https://doi.org/10.1007/7515_2020_17

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