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Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

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Flow Chemistry for the Synthesis of Heterocycles

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 56))

Abstract

The applications of flow chemistry in a drug discovery environment are discussed within. The development of integrated synthesis–bioassay platforms is discussed in the context of enabling medicinal chemistry programs, as is the use of flow chemistry to facilitate intermediate scale-up in a lead optimization setting. Emerging chemical technologies are also discussed, highlighting the use of high temperatures, hazardous gases, and photochemistry in flow to support medicinal chemistry efforts.

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Author information

Authors and Affiliations

  1. Discovery Chemistry and Technology, AbbVie, Inc., North Chicago, IL, USA

    Andrew R. Bogdan

  2. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada

    Michael G. Organ

Authors
  1. Andrew R. Bogdan
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  2. Michael G. Organ
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Corresponding author

Correspondence to Andrew R. Bogdan .

Editor information

Editors and Affiliations

  1. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Upendra K. Sharma

  2. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Erik V. Van der Eycken

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Bogdan, A.R., Organ, M.G. (2018). Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective. In: Sharma, U., Van der Eycken, E. (eds) Flow Chemistry for the Synthesis of Heterocycles. Topics in Heterocyclic Chemistry, vol 56. Springer, Cham. https://doi.org/10.1007/7081_2018_24

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