Abstract
Pyridine N-oxides are a class of mild Lewis bases that can activate certain kinds of Lewis acidic parts of molecules and hence increase reactivity of its nucleophilic part towards various reactions with electrophiles. This review aims to summarize the applications of various non-chiral and chiral pyridine N-oxides in catalysis of a variety of reactions. In addition, the applications of these reactions in syntheses of natural and bioactive compounds are mentioned as well.
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Notes
- 1.
Trichlorosilyl enolates of aldehydes and ketones as the reagents of the first choice were found not reactive enough for addition to ketones.
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Koukal, P., Ulč, J., Nečas, D., Kotora, M. (2017). Pyridine N-Oxides and Derivatives Thereof in Organocatalysis. In: Larionov, O. (eds) Heterocyclic N-Oxides. Topics in Heterocyclic Chemistry, vol 53. Springer, Cham. https://doi.org/10.1007/7081_2017_3
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