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Structure and Synthesis of Conformationally Constrained Molecules Containing Piperazic Acid

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Peptidomimetics I

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 48))

Abstract

Piperazic acid and its congeners are constituents of many structurally complex natural products. Their conformational rigidity and other advantageous physicochemical properties have motivated the incorporation of these non-proteinogenic amino acids into pharmaceutical agents and drug leads. This review provides an overview of recently published research on piperazic acids, their origins, chemical syntheses, and applications in constrained, biologically active peptides and peptidomimetics.

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Authors and Affiliations

  1. Department of Chemistry, Brown University, 324 Brook Street, Providence, RI, 02912, USA

    Emma L. Handy & Jason K. Sello

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  1. Emma L. Handy
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  2. Jason K. Sello
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Correspondence to Jason K. Sello .

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Editors and Affiliations

  1. Départemente de Chimie, Université de Montréal, Montréal, Québec, Canada

    William D. Lubell

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Handy, E.L., Sello, J.K. (2015). Structure and Synthesis of Conformationally Constrained Molecules Containing Piperazic Acid. In: Lubell, W. (eds) Peptidomimetics I. Topics in Heterocyclic Chemistry, vol 48. Springer, Cham. https://doi.org/10.1007/7081_2015_185

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