Abstract
Antibiotic resistance is considered by different international organisations (e.g. World Health Organization, WHO; Food and Agriculture Organization of the United Nations, FAO-UN; Organisation for Economic Co-operation and Development, OECD) as not only a major threat to human life and wellbeing but also having tremendous economic impacts. Recent estimates indicate that globally at least 700,000 deaths per year are due to drug-resistant infections, with the largest and most important proportion of these attributable to antibiotic-resistant bacterial infections – and which are most often identified in hospitals. However, there are reasons to believe that antibiotic-resistant bacteria are common in the community, where they are acquired from other people, animals, foods, water and/or other environmental sources.
Over recent decades, the importance of the environment in the propagation and dissemination of antibiotic-resistant bacteria has been better evidenced, with human and animal sewage representing the most important emission nodes in a complex network of transmission routes. While the relevance of environmental sources and paths of transmission are nowadays considered pivotal in any One Health discussion about antibiotic resistance, some key topics are still under debate in the scientific community.
In this chapter, experts recognised in the field were invited to give their perspective on some commonly debated topics related to the risks and control of antibiotic resistance. Specifically, five invited experts gave their perspective on the relevance and control of the environmental dimensions of antibiotic resistance, based on six distinct thematic axes – transmission, critical control points, antibiotic-selective effects, interventions needed, authority’s awareness and engagement and priorities for action.
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Notes
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Selected publications authored/co-authored by the experts panel.
References
World Health Organization (2015) Global action plan on antimicrobial resistance. World Health Organization, Geneva. ISBN 978 92 4 150976 3
Food and Agriculture Organization of the United Nations (2016) The FAO action plan on antimicrobial resistance 2016–2020 – supporting the food and agriculture sectors in implementing the global action plan on antimicrobial resistance to minimize the impact of antimicrobial resistance. Food and Agriculture Organization of the United Nations, Rome. ISBN 978-92-5-109392-4
Mcewen SA, Collignon PJ (2014) Antimicrobial resistance: a one health colloquium, pp 1–26. https://doi.org/10.1128/microbiolspec.ARBA-0009-2017.Correspondence
World Health Organization (2019) No time to wait: securing the future from drug-resistant infections. Report to the Secretary-General of the United Nations. World Health Organization, Geneva
Further Reading
Ahammad ZS, Sreekrishnan TR, Hands CL, Knapp CW, Graham DW (2014) Increased waterborne blaNDM-1 resistance gene abundances associated with seasonal human pilgrimages to the Upper Ganges River. Environ Sci Technol 48(5):3014–3020
Amos GCA, Singer AC, Bowes MJ, Gaze WH, Wellington EMH (2015) Validated predictive modelling of the environmental resistome. ISME J 9(6):1467–1476
Ashbolt NJ, Amézquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schönfeld J, Silley P, Snape JR, Van den Eede C, Topp E (2013) Human Health Risk Assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environ Health Perspect 121(9):993–1001. https://doi.org/10.1289/ehp.1206316
Berendonk TU, Manaia CM, Merlin C, Fatta-Kassinos D, Cytryn E, Walsh F, Bürgmann H, Sørum H, Norström M, Pons M, Kreuzinger N, Huovinen P, Stefani S, Schwartz T, Kisand V, Baquero F, Martinez JL (2015) Tackling antibiotic resistance: the environmental framework. Nat Rev Microbiol 13:310–317
Cleary DW, Bishop AH, Zhang L, Topp E, Wellington EM, Gaze WH (2016) Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. FEMS Microbiol Ecol 92(10):1387
Collignon P (2015) Antibiotic resistance: are we all doomed? Intern Med J 45(11):1109–1115. https://doi.org/10.1111/imj.12902
Collignon P, Beggs JJ, Walsh TR, Gandra S, Laxminarayan R (2018) Anthropological and socioeconomic factors contributing to global antimicrobial resistance: a univariate and multivariable analysis. Lancet Planet Health 2(9):e398–e405. https://doi.org/10.1016/S2542-5196(18)30186-4
Fisher PM, Smith DA, Collignon PJ (2013) The after-life of drugs: a responsible care initiative for reducing their environmental impact. Med J Aust 199(6):388–390
Graham DW, Collignon P, Davies J, Larsson DG, Snape J (2014) Underappreciated role of regionally poor water quality on globally increasing antibiotic resistance. Environ Sci Technol 48(20):11746–11747. https://doi.org/10.1021/es504206x
Graham DW, Giesen MJ, Bunce JT (2019) Strategic approach for prioritising local and regional sanitation interventions for reducing global antibiotic resistance. Water 11(1):27
Graham DW, Knapp CW, Christensen BT, McCluskey S, Dolfing J (2016) Appearance of β-lactam resistance genes in agricultural soils and clinical isolates over the twentieth century. Sci Rep 6:21550
Hernando-Amado S, Coque TM, Baquero F, Martinez JL (2019) Defining and combating antibiotic resistance from One Health and global health perspectives. Nat Microbiol 4(9):1432–1442. https://doi.org/10.1038/s41564-019-0503-9
Klümper U, Recker M, Zhang L, Yin X, Zhang T, Buckling A, Gaze W (2019) Selection for antimicrobial resistance is reduced when embedded in a natural microbial community. ISME J 13(12):2927–2937. 1–11
Lamba M, Gupta S, Shukla R, Graham DW, Sreekrishnan TR, Ahammad ZS (2018) Carbapenem resistance exposures via wastewaters across New Delhi. Environ Int 119:302–308
Lau CH-F, Li B, Zhang T, Tien Y-C, Scott A, Murray R, Sabourin L, Lapen DR, Duenk P, Topp E (2017) Impact of pre-application treatment on municipal sludge composition, soil dynamics of antibiotic resistance genes, and abundance of antibiotic-resistance genes on vegetables at harvest. Sci Total Environ 587-588:214–222. https://doi.org/10.1016/j.scitotenv.2017.02.123
Leonard AFC, Zhang L, Balfour AJ, Garside R, Hawkey PM, Murray AK, Ukoumunne OC, Gaze WH (2018) Exposure to and colonisation by antibiotic-resistant E. coli in UK coastal water users: environmental surveillance, exposure assessment, and epidemiological study (Beach Bum Survey). Environ Int 114:326–333. https://doi.org/10.1016/j.envint.2017.11.003
Marti R, Scott A, Tien Y-C, Murray R, Sabourin L, Zhang Y, Topp E (2013) The impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil, and on vegetables at harvest. Appl Environ Microbiol 79:5701–5709. https://doi.org/10.1128/aem.01682-13
Martínez JL (2008) Antibiotics and antibiotic resistance genes in natural environments. Science 321:365–367
Martínez JL (2014) General principles of antibiotic resistance in bacteria. Drug Discov Today Technol 11:33–39
Martínez JL (2017) Effect of antibiotics on bacterial populations: a multi-hierarchical selection process. F1000Res 17(6):51
McCann CM, Christgen B, Roberts JA, Su JQ, Arnold KE, Gray ND, Zhu YG, Graham DW (2019) Understanding drivers of antibiotic resistance genes in high Arctic soil ecosystems. Environ Int 125:497–504
McEwen SA, Collignon PJ (2018) Antimicrobial resistance: a one health perspective. Microbiol Spectr 6(2). https://doi.org/10.1128/microbiolspec.ARBA-0009-2017
Murray AK, Zhang L, Yin X, Zhang T, Buckling A, Snape J, Gaze WH (2018) Novel insights into selection for antibiotic resistance in complex microbial communities. MBio 24(9):4
Pruden A, Larsson DG, Amézquita A, Collignon P, Brandt KK, Graham DW, Lazorchak JM, Suzuki S, Silley P, Snape JR, Topp E, Zhang T, Zhu YG (2013) Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment. Environ Health Perspect 121(8):878–885. https://doi.org/10.1289/ehp.1206446
Quintela-Baluja M, Abouelnaga M, Romalde J, Su J-Q, Yu Y, Gomez-Lopez M, Smets B, Zhu YG, Graham DW (2019) Spatial ecology of a wastewater network defines the antibiotic resistance genes in downstream receiving waters. Water Res 162:347–357
Tien Y-C, Li B, Zhang T, Scott A, Murray R, Sabourin L, Marti R, Topp E (2017) Impact of dairy manure pre-application treatment on manure composition, soil dynamics of antibiotic resistance genes, and abundance of antibiotic-resistance genes on vegetables at harvest. Sci Total Environ 581–582:32–39. https://doi.org/10.1016/j.scitotenv.2016.12.138
Topp E (2017) Agriculture and Agri-Food Canada’s research program on antimicrobial resistance. Can Commun Dis Rep 43(11):224–227
Topp E, Larsson J, Miller D, Van den Eede C, Virta M (2017) Antimicrobial resistance and the environment: Assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing. FEMS Microbiol Ecol 94:fix185. https://doi.org/10.1093/femsec/fix185
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Manaia, C.M., Graham, D., Topp, E., Martinez, J.L., Collignon, P., Gaze, W.H. (2020). Antibiotic Resistance in the Environment: Expert Perspectives. In: Manaia, C., Donner, E., Vaz-Moreira, I., Hong, P. (eds) Antibiotic Resistance in the Environment . The Handbook of Environmental Chemistry, vol 91. Springer, Cham. https://doi.org/10.1007/698_2020_472
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