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Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report

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Invasive Diagnostics and Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((CLEXBI,volume 1374))

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Abstract

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, characterized by symmetrical arthritis, and deterioration of articular cartilage and epiphyses leading to progressive destruction and deformation of joints, resulting in disability. The purpose of this chapter is to evaluate the effects of treatment with anti-inflammatory biologic medication, Enbrel (Etanercept), during therapeutic rehabilitation in RA patients. The sample comprised 10 hospitalized patients (8 females and 2 males) of the mean age of 32.2 ± 13.4 years treated with Enbrel in 2008–2010. The drug was administered subcutaneously in a dose of 50 mg once a week. Outcomes consisted of differences in the Disease Activity Score (DAS-28) and the degree of joint impairment based on the Health Assessment Questionnaire (HAQ) noted 2 months after treatment onset. The average pre-/post-treatment DAS-28 score was 4.1/2.6, with improvement in 9 patients. The average HAQ score was 1.5/0.6, respectively. We conclude that treatment with Enbrel significantly reduces RA activity and improved joint impairment. The beneficial influence of the drug enabled an earlier commencement of physical rehabilitation, which may have a preventive bearing on the development of disability.

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Conflicts of Interest

The authors declare no conflicts of interest concerning this study.

Ethical Approval

All procedures performed in studies involving human participants followed the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the institutional Bioethics Committee (permit RNN/216/06/KB).

Informed Consent

Written informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of Orthopedics, Traumatology and Sports Medicine, Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland

    Jacek Lorkowski

  2. Department of Internal Medicine and Rheumatology, Military Institute of Medicine, Warsaw, Poland

    Robert Mętrak

  3. Department of Orthopedics and Rehabilitation, College of Medicine, Jagiellonian University, Zakopane, Poland

    Barbara Jasiewicz

Authors
  1. Jacek Lorkowski
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  2. Robert Mętrak
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  3. Barbara Jasiewicz
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Corresponding author

Correspondence to Jacek Lorkowski .

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Editors and Affiliations

  1. Institute of Health Sciences, Opole University, Opole, Poland

    Mieczyslaw Pokorski

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Lorkowski, J., Mętrak, R., Jasiewicz, B. (2021). Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report. In: Pokorski, M. (eds) Invasive Diagnostics and Therapy. Advances in Experimental Medicine and Biology(), vol 1374. Springer, Cham. https://doi.org/10.1007/5584_2021_685

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