Abstract
Pulmonary metastasectomy is a well-established contribution to the cure of oligometastatic cancers, but its exact effectiveness is poorly understood. Here we report the outcomes of repeat pulmonary metastasectomy from a multicenter trial. This retrospective study included patients who underwent re-do metastasectomies between January 2010 and December 2014. The exclusion criterion was metastasectomy without curative intent. We reviewed medical files of 621 consecutive patients who underwent initial pulmonary metastasectomy. Of those, 64 patients underwent repeat metastasectomies, and these patients were included in the analysis. All the 64 patients underwent a second metastasectomy, later 35 of them underwent a third metastasectomy, 12 underwent a fourth metastasectomy, and 6 underwent a fifth metastasectomy. The total number of re-do metastasectomies was 181. The median overall survival among the patients undergoing re-do metastasectomy was 66.0 ± 3.8 months. Three and 5-year survival rates were 82.3% and 63.3%, respectively. The 5-year survival rates were 63.3% after the first, 50.9% after the second, 74.4% after the third, 83.3% after the fourth, and 60.0% after the fifth metastasectomy. We conclude that at the current stage of knowledge, there is an indication for repeat re-do metastasectomy with curative intent.
The original version of this chapter was revised: Chapter title was modified. The correction to this chapter is available at https://doi.org/10.1007/5584_2021_650
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Borasio P, Gisabella M, Billé A, Righi L, Longo M, Tampellini M, Ardissone F (2011) Role of surgical resection in colorectal lung metastases: analysis of 137 patients. Int J Color Dis 26(2):183–190
Cheung F, Alam N, Wright G (2018) Pulmonary metastasectomy: analysis of survival and prognostic factors in 243 patients. ANZ J Surg 88(12):1316–1321
Chudgar NP, Brennan MF, Tan KS, Munhoz RR, D’Angelo SP, Bains MS, Huang J, Park BJ, Adusumilli PS, Tap WD, Jones DR (2017) Is repeat pulmonary metastasectomy indicated for soft tissue sarcoma? Ann Thorac Surg 104(6):1837–1845
Hachimaru A, Maeda R, Suda T, Takagi Y (2016) Repeat pulmonary resection for recurrent lung metastases from colorectal cancer: an analysis of prognostic factors. Interact Cardiovasc Thorac Surg 22(6):826–830
Hellman S, Weichselbaum RR (1995) Oligometastases. J Clin Oncol 13:8–10
Hishida T, Tsuboi M, Okumura T, Boku N, Ohde Y, Sakao Y, Yoshiya K, Hyodo I, Mori K, Kondo H (2017) Does repeated lung resection provide long-term survival for recurrent pulmonary metastases of colorectal cancer? Results of a retrospective Japanese Multicenter Study. Ann Thorac Surg 103(2):399–405
Matsumoto T, Hasegawa S, Hida K, Kawada K, Sakai Y, Sugihara K (2019) Role of repeat resection in patients with metastatic colorectal cancer: a multicenter retrospective study. Dis Colon Rectum 62(5):561–567
Menna C, Berardi G, Tierno SM, Andreetti C, Maurizi G, Ciccone AM, D’Andrilli A, Cassiano F, Poggi C, Diso D, Venuta F, Rendina EA, Ibrahim M (2018) Do repeated operations for recurrent colorectal lung metastases result in improved survival? Ann Thorac Surg 106(2):421–427
Mineo TC, Ambrogi V, Tacconi F, Mineo D (2015) Multi-reoperations for lung metastases. Future Oncol 11(2 Suppl):37–41
Mizuguchi S, Nishiyama N, Izumi N, Tsukioka T, Komatsu H, Iwata T, Tanaka S, Takemura S, Kubo S (2016) Clinical significance of multiple pulmonary metastasectomy for hepatocellular carcinoma. World J Surg 40(2):380–387
Niibe Y, Hayakawa K (2010) Oligometastases and oligo-recurrence: the new era of cancer therapy. Jpn J Clin Oncol 40:107–111
Park JS, Kim HK, Choi YS, Kim K, Shim YM, Jo J, Lee WY, Chun HK, Park YS, Kang WK, Kim J (2010) Outcomes after repeated resection for recurrent pulmonary metastases from colorectal cancer. Ann Oncol 21(6):1285–1289
Salah S, Watanabe K, Park JS, Addasi A, Park JW, Zabaleta J, Ardissone F, Kim J, Riquet M, Nojiri K, Gisabella M, Kim SY, Tanaka K (2013) Repeated resection of colorectal cancer pulmonary oligometastases: pooled analysis and prognostic assessment. Ann Surg Oncol 20(6):1955–1961
Sponholz S, Schirren M, Baldes N, Oguzhan S, Schirren J (2017) Repeat resection for recurrent pulmonary metastasis of colorectal cancer. Langenbeck’s Arch Surg 402(1):77–85
Welter S, Jacobs J, Krbek T, Stamatis G (2007) Long-term survival after repeated resection of pulmonary metastases from colorectal cancer. Ann Thorac Surg 84(1):203–210
Yamamoto Y, Kanzaki R, Kanou T, Ose N, Funaki S, Shintani Y, Minami M, Outani H, Takenaka S, Hamada K, Yoshikawa H, Okumura M (2019) Long–term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma. Int J Clin Oncol 24(7):863–870
Yang KM, Park IJ, Lee JL, Kim CW, Yoon YS, Lim SB, Yu CS, Kim JC (2020) Benefits of repeated resections for liver and lung metastases from colorectal cancer. Asian J Surg 43(1):102–109
Conflicts of Interest
The authors declare no conflicts of interest concerning this study.
Ethical Approval
This chapter based on a retrospective review of medical files does not contain any direct studies with human participants performed by any of the authors. The work was approved by a local Ethics Committee at Hannover Medical School (IRB no. 2879-2015).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Krüger, M. et al. (2021). Outcome of Repeat Pulmonary Metastasectomy. In: Pokorski, M. (eds) Best Practice in Health Care. Advances in Experimental Medicine and Biology(), vol 1335. Springer, Cham. https://doi.org/10.1007/5584_2021_635
Download citation
DOI: https://doi.org/10.1007/5584_2021_635
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-77741-8
Online ISBN: 978-3-030-77742-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)