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Hematological Malignancies and Fertility

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Cell Biology and Translational Medicine, Volume 9

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1288))

Abstract

In the last decades, survival rate of hematological malignancies has been significantly improved and sparing reproductive potential after treatment has become one of the goals in both male and female patients. A comprehensive consultation with reproductive specialists before the onset of any kind of cancer treatment procedure is an essential issue which would increase the likelihood of parenting in survivors. In this context, cryopreservation of oocyte, embryo or ovarian tissue in reproductive aged women and sperm or testicular tissue cryopreservation in adult male are feasible approaches that must be considered before gonadotoxic therapy. Notably, all options should be regarded as experimental during pre-pubertal period. Herein, we aim to review the available literature with regard to safety, efficacy of fertility preservation methods and the pregnancy outcomes in patients with hematological malignancies.

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Abbreviations

AL:

Acute leukemia

Allo-HSCT:

Allogeneic hematopoietic stem cell transplantation

AMH:

Anti-Mullerian hormone

ASCO:

American Society of Clinical Oncology

cGVHD:

Chronic graft versus host disease

CIBMTR:

Center for International Blood and Marrow Transplant Registry

CML:

Chronic myeloid leukemia

CRT:

Cranial radiation therapy

Cy:

Cyclophosphamide

DLBCL:

Diffuse large B cell lymphoma

EBMT:

European Bone Marrow Transplantation

FL:

Follicular lymphoma

FORT:

Follicular output rate

FSH:

Follicle stimulating hormone

GnRHa:

Gonadotropin-releasing hormone agonists

Gy:

Gray

HL:

Hodgkin lymphoma

HSCT:

Hematopoietic stem cell transplantation

IVM:

Invitro maturation of immature oocytes

LH:

Luteinizing hormone

MA:

Myeloablative

MMR:

Major molecular response

NHL:

Non-Hodgkin lymphoma

OTC:

Ovarian tissue cryopreservation

OTT:

Ovarian tissue transplantation

PCR:

Polymerase chain reaction

POF:

Primary ovarian failure

RIC:

Reduced intensity conditioning

TBI:

Total body irradiation

TKI:

Tyrosine kinase inhibitor

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Authors and Affiliations

  1. Ankara City Hospital, Ankara, Turkey

    Zehra Narli Ozdemir

  2. Faculty of Medicine, Department of Hematology, Ankara University, Ankara, Turkey

    Sinem Civriz Bozdag

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  1. Zehra Narli Ozdemir
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  2. Sinem Civriz Bozdag
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Correspondence to Sinem Civriz Bozdag .

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  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Ozdemir, Z.N., Bozdag, S.C. (2020). Hematological Malignancies and Fertility. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 9. Advances in Experimental Medicine and Biology(), vol 1288. Springer, Cham. https://doi.org/10.1007/5584_2020_490

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