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Quality of Life in Patients with Advanced Non-Small-Cell Lung Cancer Receiving Palliative Chemotherapy

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Advances in Pulmonary Medicine: Research and Innovations

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 1160))

Abstract

The goal of this study was to explore quality of life in patients with advanced non-small-cell lung cancer (NSCLC) in an attempt to single out features that could help predict the possibility of non-completion of chemotherapy. The survey tool was the Quality of Life Questionnaire Core-30 (QLQ-C30) with the module Lung Cancer 13 (LC-13) developed by the European Organization for Research and Treatment of Cancer. The assessment of quality of life (QoL) was performed in 58 patients with advanced NSCLC before palliative chemotherapy and it was repeated in 43 patients who completed at least three cycles of chemotherapy. We found that the patients who failed to complete the chemotherapy course distinctly showed, in contradistinction to those who completed it, poor physical functioning in (67.6 ± 16.3 vs. 78.3 ± 21.3 points, respectively, p < 0.05) and the lack of appetite (27.1 ± 38.0 vs. 48.9 ± 37.5 points, respectively p < 0.05). At the end of palliative chemotherapy alopecia, sore throat, and constipation significantly worsened QoL, but global health status remained unchanged. In conclusion, poor physical functioning and loss of appetite seem to harbinger a risk of non-completion of chemotherapy in advanced NSCLC.

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Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Wrocław Medical University in Wrocław Poland. The authors obtained written permission from EORTC to adopt and use a Polish version of QLQ-C30 and QLQ-LC13 questionnaires.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Author information

Authors and Affiliations

  1. Department of Pulmonology and Lung Cancer, Wrocław Medical University, Wrocław, Poland

    Cyryl Daroszewski & Anna Brzecka

  2. Lower Silesian Center of Lung Diseases, Wrocław, Poland

    Małgorzata Stasiewicz

  3. Department of Clinical Pharmacology, Wrocław Medical University, Wrocław, Poland

    Ewa Jaźwińska-Tarnawska

  4. Student’s Scientific Association, Wrocław Medical University, Wrocław, Poland

    Anna Rachwalik & Ewa Mura

  5. Department of Physical Chemistry, Wrocław Medical University, Wrocław, Poland

    Joanna Luboch-Kowal & Andrzej Dryś

  6. Department of Dental Prosthetics, Wrocław Medical University, Wrocław, Poland

    Zdzisław A. Bogucki

Authors
  1. Cyryl Daroszewski
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  2. Małgorzata Stasiewicz
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  3. Ewa Jaźwińska-Tarnawska
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  5. Ewa Mura
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  8. Zdzisław A. Bogucki
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  9. Anna Brzecka
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Corresponding author

Correspondence to Ewa Jaźwińska-Tarnawska .

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Editors and Affiliations

  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Daroszewski, C. et al. (2019). Quality of Life in Patients with Advanced Non-Small-Cell Lung Cancer Receiving Palliative Chemotherapy. In: Pokorski, M. (eds) Advances in Pulmonary Medicine: Research and Innovations. Advances in Experimental Medicine and Biology(), vol 1160. Springer, Cham. https://doi.org/10.1007/5584_2019_346

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