Skip to main content
SpringerLink
Log in

Evolving Role of Natriuretic Peptides from Diagnostic Tool to Therapeutic Modality

  • Chapter
  • First Online:
Heart Failure: From Research to Clinical Practice

Part of the book series: Advances in Experimental Medicine and Biology ((AIM,volume 1067))

Abstract

Natriuretic peptides (NP) are widely recognized as key regulators of blood pressure, water and salt homeostasis. In addition, they play a critical role in physiological cardiac growth and mediate a variety of biological effects including antiproliferative and anti-inflammatory effects in other organs and tissues. The cardiac release of NPs ANP and BNP represents an important compensatory mechanism during acute and chronic cardiac overload and during the pathogenesis of heart failure where their actions counteract the sustained activation of renin-angiotensin-aldosterone and other neurohormonal systems. Elevated circulating plasma NP levels correlate with the severity of heart failure and particularly BNP and the pro-peptide, NT-proBNP have been established as biomarkers for the diagnosis of heart failure as well as prognostic markers for cardiovascular risk. Despite activation of the NP system in heart failure it is inadequate to prevent progressive fluid and sodium retention and cardiac remodeling. Therapeutic approaches included administration of synthetic peptide analogs and the inhibition of NP-degrading enzyme neutral endopeptidase (NEP). Of all strategies only the combined NEP/ARB inhibition with sacubitril/valsartan had shown clinical success in reducing cardiovascular mortality and morbidity in patients with heart failure.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abassi ZA, Yahia A, Zeid S, Karram T, Golomb E, Winaver J, Hoffman A (2005) Cardiac and renal effects of omapatrilat, a vasopeptidase inhibitor, in rats with experimental congestive heart failure. Am J Physiol Heart Circ Physiol 288(2):H722–H728

    Article  PubMed  CAS  Google Scholar 

  • Agarwal SK, Chambless LE, Ballantyne CM, Astor B, Bertoni AG, Chang PP, Folsom AR, He M, Hoogeveen RC, Ni H, Quibrera PM, Rosamond WD, Russell SD, Shahar E, Heiss G (2012) Prediction of incident heart failure in general practice: the Atherosclerosis Risk in Communities (ARIC) Study. Circ Heart Fail 5(4):422–429

    Article  PubMed  PubMed Central  Google Scholar 

  • Anand IS, Fisher LD, Chiang YT, Latini R, Masson S, Maggioni AP, Glazer RD, Tognoni G, Cohn JN (2003) Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT). Circulation 107(9):1278–1283

    Article  PubMed  CAS  Google Scholar 

  • Anand-Srivastava MB, Trachte GJ (1993) Atrial natriuretic factor receptors and signal transduction mechanisms. Pharmacol Rev 45(4):455–497

    PubMed  CAS  Google Scholar 

  • Barbee RW, Perry BD, Re RN, Murgo JP, Field LJ (1994) Hemodynamics in transgenic mice with overexpression of atrial natriuretic factor. Circ Res 74(4):747–751

    Article  PubMed  CAS  Google Scholar 

  • Bayes-Genis A, Barallat J, Richards AM (2016) A test in context: neprilysin: function, inhibition, and biomarker. J Am Coll Cardiol 68(6):639–653

    Article  PubMed  CAS  Google Scholar 

  • Biollaz J, Callahan LT, 3rd, Nussberger J, Waeber B, Gomez HJ, Blaine EH, Brunner HR (1987) Pharmacokinetics of synthetic atrial natriuretic peptides in normal men. Clin Pharmacol Ther 41(6):671–677

    Article  PubMed  CAS  Google Scholar 

  • Birkenfeld AL, Budziarek P, Boschmann M, Moro C, Adams F, Franke G, Berlan M, Marques MA, Sweep FC, Luft FC, Lafontan M, Jordan J (2008) Atrial natriuretic peptide induces postprandial lipid oxidation in humans. Diabetes 57(12):3199–3204

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Brunner-La Rocca HP, Eurlings L, Richards AM, Januzzi JL, Pfisterer ME, Dahlstrom U, Pinto YM, Karlstrom P, Erntell H, Berger R, Persson H, O’Connor CM, Moertl D, Gaggin HK, Frampton CM, Nicholls MG, Troughton RW (2015) Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials. Eur J Heart Fail 17(12):1252–1261

    Article  PubMed  CAS  Google Scholar 

  • Burnett JC Jr (2006) Novel therapeutic directions for the natriuretic peptides in cardiovascular diseases: what’s on the horizon. J Cardiol 48(5):235–241

    PubMed  PubMed Central  Google Scholar 

  • Cabiati M, Campan M, Caselli C, Prescimone T, Giannessi D, Del Ry S (2010) Sequencing and cardiac expression of natriuretic peptide receptors A and C in normal and heart failure pigs. Regul Pept 162(1–3):12–17

    Article  PubMed  CAS  Google Scholar 

  • Cao L, Gardner DG (1995) Natriuretic peptides inhibit DNA synthesis in cardiac fibroblasts. Hypertension 25(2):227–234

    Article  PubMed  CAS  Google Scholar 

  • Carubelli V, Lombardi C, Lazzarini V, Bonadei I, Castrini AI, Gorga E, Richards AM, Metra M (2016) N-terminal pro-B-type natriuretic peptide-guided therapy in patients hospitalized for acute heart failure. J Cardiovasc Med (Hagerstown) 17(11):828–839

    Article  CAS  Google Scholar 

  • Cataliotti A, Schirger JA, Martin FL, Chen HH, McKie PM, Boerrigter G, Costello-Boerrigter LC, Harty G, Heublein DM, Sandberg SM, James KD, Miller MA, Malkar NB, Polowy K, Burnett JC Jr (2005) Oral human brain natriuretic peptide activates cyclic guanosine 3′,5′-monophosphate and decreases mean arterial pressure. Circulation 112(6):836–840

    Article  PubMed  CAS  Google Scholar 

  • Cataliotti A, Chen HH, Schirger JA, Martin FL, Boerrigter G, Costello-Boerrigter LC, James KD, Polowy K, Miller MA, Malkar NB, Bailey KR, Burnett JC Jr (2008) Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension. Circulation 118(17):1729–1736

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chahal H, Bluemke DA, CO W, McClelland R, Liu K, Shea SJ, Burke G, Balfour P, Herrington D, Shi P, Post W, Olson J, Watson KE, Folsom AR, Lima JA (2015) Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Heart 101(1):58–64

    Article  PubMed  CAS  Google Scholar 

  • Chai SY, Sexton PM, Allen AM, Figdor R, Mendelsohn FA (1986) In vitro autoradiographic localization of ANP receptors in rat kidney and adrenal gland. Am J Physiol 250(4 Pt 2):F753–F757

    PubMed  CAS  Google Scholar 

  • Charles CJ, Espiner EA, Nicholls MG, Richards AM, Yandle TG, Protter A, Kosoglou T (1996) Clearance receptors and endopeptidase 24.11: equal role in natriuretic peptide metabolism in conscious sheep. Am J Physiol 271(2 Pt 2):R373–R380

    PubMed  CAS  Google Scholar 

  • Chen YF (2005) Atrial natriuretic peptide in hypoxia. Peptides 26(6):1068–1077

    Article  PubMed  CAS  Google Scholar 

  • Chen HH, Lainchbury JG, Burnett JC Jr (2002) Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide. J Am Coll Cardiol 40(6):1186–1191

    Article  PubMed  CAS  Google Scholar 

  • Chow SL, Maisel AS, Anand I, Bozkurt B, de Boer RA, Felker GM, Fonarow GC, Greenberg B, Januzzi JL Jr, Kiernan MS, Liu PP, Wang TJ, Yancy CW, Zile MR (2017) Role of biomarkers for the prevention, assessment, and management of heart failure: a scientific statement from the American Heart Association. Circulation 135(22):e1054–e1091

    Article  PubMed  CAS  Google Scholar 

  • Chusho H, Tamura N, Ogawa Y, Yasoda A, Suda M, Miyazawa T, Nakamura K, Nakao K, Kurihara T, Komatsu Y, Itoh H, Tanaka K, Saito Y, Katsuki M (2001) Dwarfism and early death in mice lacking C-type natriuretic peptide. Proc Natl Acad Sci U S A 98(7):4016–4021

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Clavell AL, Stingo AJ, Wei CM, Heublein DM, Burnett JC Jr (1993) C-type natriuretic peptide: a selective cardiovascular peptide. Am J Physiol 264(2 Pt 2):R290–R295

    PubMed  CAS  Google Scholar 

  • Cody RJ, Atlas SA, Laragh JH, Kubo SH, Covit AB, Ryman KS, Shaknovich A, Pondolfino K, Clark M, Camargo MJ et al (1986) Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion. J Clin Invest 78(5):1362–1374

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Collins S (2014) A heart-adipose tissue connection in the regulation of energy metabolism. Nat Rev Endocrinol 10(3):157–163

    Article  PubMed  CAS  Google Scholar 

  • Collins S, Storrow AB, Albert NM, Butler J, Ezekowitz J, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hiestand B, Hollander JE, Lanfear DE, Levy PD, Pang PS, Peacock WF, Sawyer DB, Teerlink JR, Lenihan DJ (2015) Early management of patients with acute heart failure: state of the art and future directions. A consensus document from the society for academic emergency medicine/heart failure society of America acute heart failure working group. J Card Fail 21(1):27–43

    Article  PubMed  Google Scholar 

  • Colucci WS, Elkayam U, Horton DP, Abraham WT, Bourge RC, Johnson AD, Wagoner LE, Givertz MM, Liang CS, Neibaur M, Haught WH, LeJemtel TH (2000) Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. Nesiritide Study Group. N Engl J Med 343(4):246–253

    Article  PubMed  CAS  Google Scholar 

  • Corthorn J, Cantin M, Thibault G (1991) Rat atrial secretory granules and pro-ANF processing enzyme. Mol Cell Biochem 103(1):31–39

    Article  PubMed  CAS  Google Scholar 

  • de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28(1):89–94

    Article  PubMed  Google Scholar 

  • Dickey DM, Potter LR (2011) Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation. J Mol Cell Cardiol 51(1):67–71

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dickstein K, De Voogd HJ, Miric MP, Willenbrock R, Mitrovic V, Pacher R, Koopman PA (2004) Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure. Am J Cardiol 94(2):237–239

    Article  PubMed  CAS  Google Scholar 

  • Dietz R, Lang RE, Purgaj J, Merkel A, Schomig A, Kubler W (1986) Relationships between haemodynamic parameters and concentrations of atrial natriuretic peptide in human plasma. J Hypertens Suppl 4(6):S512–S515

    PubMed  CAS  Google Scholar 

  • Dietz JR, Vesely DL, Gower WR Jr, Nazian SJ (1995) Secretion and renal effects of ANF prohormone peptides. Clin Exp Pharmacol Physiol 22(2):115–120

    Article  PubMed  CAS  Google Scholar 

  • Engeli S, Birkenfeld AL, Badin PM, Bourlier V, Louche K, Viguerie N, Thalamas C, Montastier E, Larrouy D, Harant I, de Glisezinski I, Lieske S, Reinke J, Beckmann B, Langin D, Jordan J, Moro C (2012) Natriuretic peptides enhance the oxidative capacity of human skeletal muscle. J Clin Invest 122(12):4675–4679

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Eskay R, Zukowska-Grojec Z, Haass M, Dave JR, Zamir N (1986) Circulating atrial natriuretic peptides in conscious rats: regulation of release by multiple factors. Science 232(4750):636–639

    Article  PubMed  CAS  Google Scholar 

  • Espiner EA, Crozier IG, Nicholls MG, Cuneo R, Yondle TG, Ikram H (1985) Cardiac secretion of atrial natriuretic peptide. Lancet 2(8451):398–399

    Article  PubMed  CAS  Google Scholar 

  • FDA (2001) Clinical chemistry and clinical toxicology devices; classification of B-type natriuretic peptide test system. Food and Drug Administration, HHS. Final rule. Fed Regist 66(40):12733–12734

    Google Scholar 

  • Feller SM, Gagelmann M, Forssmann WG (1989) Urodilatin: a newly described member of the ANP family. Trends Pharmacol Sci 10(3):93–94

    Article  PubMed  CAS  Google Scholar 

  • Feng JA, Perry G, Mori T, Hayashi T, Oparil S, Chen YF (2003) Pressure-independent enhancement of cardiac hypertrophy in atrial natriuretic peptide-deficient mice. Clin Exp Pharmacol Physiol 30(5-6):343–349

    Article  PubMed  CAS  Google Scholar 

  • Fifer MA, Molina CR, Quiroz AC, Giles TD, Herrmann HC, De Scheerder IR, Clement DL, Kubo S, Cody RJ, Cohn JN et al (1990) Hemodynamic and renal effects of atrial natriuretic peptide in congestive heart failure. Am J Cardiol 65(3):211–216

    Article  PubMed  CAS  Google Scholar 

  • Florkowski CM, Richards AM, Espiner EA, Yandle TG, Frampton C (1994) Renal, endocrine, and hemodynamic interactions of atrial and brain natriuretic peptides in normal men. Am J Physiol 266(4 Pt 2):R1244–R1250

    PubMed  CAS  Google Scholar 

  • Forssmann WG, Richter R, Meyer M (1998) The endocrine heart and natriuretic peptides: histochemistry, cell biology, and functional aspects of the renal urodilatin system. Histochem Cell Biol 110(4):335–357

    Article  PubMed  CAS  Google Scholar 

  • Fruhwald FM, Fahrleitner-Pammer A, Berger R, Leyva F, Freemantle N, Erdmann E, Gras D, Kappenberger L, Tavazzi L, Daubert JC, Cleland JG (2007) Early and sustained effects of cardiac resynchronization therapy on N-terminal pro-B-type natriuretic peptide in patients with moderate to severe heart failure and cardiac dyssynchrony. Eur Heart J 28(13):1592–1597

    Article  PubMed  CAS  Google Scholar 

  • Furuya M, Miyazaki T, Honbou N, Kawashima K, Ohno T, Tanaka S, Kangawa K, Matsuo H (1995) C-type natriuretic peptide inhibits intimal thickening after vascular injury. Ann N Y Acad Sci 748:517–523

    Article  PubMed  CAS  Google Scholar 

  • Gardner DG, Hane S, Trachewsky D, Schenk D, Baxter JD (1986) Atrial natriuretic peptide mRNA is regulated by glucocorticoids in vivo. Biochem Biophys Res Commun 139(3):1047–1054

    Article  PubMed  CAS  Google Scholar 

  • George SG, Kenny J (1973) Studies on the enzymology of purified preparations of brush border from rabbit kidney. Biochem J 134(1):43–57

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gong B, Wu Z, Li Z (2016) Efficacy and safety of nesiritide in patients with decompensated heart failure: a meta-analysis of randomised trials. BMJ Open 6(1):e008545

    Article  PubMed  PubMed Central  Google Scholar 

  • Hamet P, Tremblay J (1991) Evaluating atrial natriuretic peptide-induced cGMP production by particulate guanylyl cyclase stimulation in vitro and in vivo. Methods Enzymol 195:447–461

    Article  PubMed  CAS  Google Scholar 

  • Hasegawa K, Fujiwara H, Itoh H, Nakao K, Fujiwara T, Imura H, Kawai C (1991) Light and electron microscopic localization of brain natriuretic peptide in relation to atrial natriuretic peptide in porcine atrium. Immunohistocytochemical study using specific monoclonal antibodies. Circulation 84(3):1203–1209

    Article  PubMed  CAS  Google Scholar 

  • Hauptman PJ, Schnitzler MA, Swindle J, Burroughs TE (2006) Use of nesiritide before and after publications suggesting drug-related risks in patients with acute decompensated heart failure. Jama 296(15):1877–1884

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hill SA, Booth RA, Santaguida PL, Don-Wauchope A, Brown JA, Oremus M, Ali U, Bustamam A, Sohel N, McKelvie R, Balion C, Raina P (2014) Use of BNP and NT-proBNP for the diagnosis of heart failure in the emergency department: a systematic review of the evidence. Heart Fail Rev 19(4):421–438

    Article  PubMed  CAS  Google Scholar 

  • Horio T, Tokudome T, Maki T, Yoshihara F, Suga S, Nishikimi T, Kojima M, Kawano Y, Kangawa K (2003) Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts. Endocrinology 144(6):2279–2284

    Article  PubMed  CAS  Google Scholar 

  • Huang Y, Ng XW, Lim SG, Chen HH, Burnett JC Jr, Boey YC, Venkatraman SS (2016) In vivo evaluation of cenderitide-eluting stent (CES) II. Ann Biomed Eng 44(2):432–441

    Article  PubMed  Google Scholar 

  • Hutchinson HG, Trindade PT, Cunanan DB, CF W, Pratt RE (1997) Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells. Cardiovasc Res 35(1):158–167

    Article  PubMed  CAS  Google Scholar 

  • Ichiki T, Huntley BK, Burnett JC Jr (2013) BNP molecular forms and processing by the cardiac serine protease corin. Adv Clin Chem 61:1–31

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Itoh T, Nagaya N, Murakami S, Fujii T, Iwase T, Ishibashi-Ueda H, Yutani C, Yamagishi M, Kimura H, Kangawa K (2004) C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med 170(11):1204–1211

    Article  PubMed  Google Scholar 

  • Januzzi JL Jr, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, Tung R, Cameron R, Nagurney JT, Chae CU, Lloyd-Jones DM, Brown DF, Foran-Melanson S, Sluss PM, Lee-Lewandrowski E, Lewandrowski KB (2005) The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol 95(8):948–954

    Article  PubMed  CAS  Google Scholar 

  • Januzzi JL Jr, Rehman SU, Mohammed AA, Bhardwaj A, Barajas L, Barajas J, Kim HN, Baggish AL, Weiner RB, Chen-Tournoux A, Marshall JE, Moore SA, Carlson WD, Lewis GD, Shin J, Sullivan D, Parks K, Wang TJ, Gregory SA, Uthamalingam S, Semigran MJ (2011) Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction. J Am Coll Cardiol 58(18):1881–1889

    Article  PubMed  CAS  Google Scholar 

  • John SW, Krege JH, Oliver PM, Hagaman JR, Hodgin JB, Pang SC, Flynn TG, Smithies O (1995) Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science 267(5198):679–681

    Article  PubMed  CAS  Google Scholar 

  • Jordan J, Stinkens R, Jax T, Engeli S, Blaak EE, May M, Havekes B, Schindler C, Albrecht D, Pal P, Heise T, Goossens GH, Langenickel TH (2017) Improved insulin sensitivity with angiotensin receptor neprilysin inhibition in individuals with obesity and hypertension. Clin Pharmacol Ther 101(2):254–263

    Article  PubMed  CAS  Google Scholar 

  • Kambayashi Y, Nakao K, Mukoyama M, Saito Y, Ogawa Y, Shiono S, Inouye K, Yoshida N, Imura H (1990) Isolation and sequence determination of human brain natriuretic peptide in human atrium. FEBS Lett 259(2):341–345

    Article  PubMed  CAS  Google Scholar 

  • Kashiwagi M, Katafuchi T, Kato A, Inuyama H, Ito T, Hagiwara H, Takei Y, Hirose S (1995) Cloning and properties of a novel natriuretic peptide receptor, NPR-D. Eur J Biochem 233(1):102–109

    Article  PubMed  CAS  Google Scholar 

  • Kentsch M, Ludwig D, Drummer C, Gerzer R, Muller-Esch G (1992) Haemodynamic and renal effects of urodilatin in healthy volunteers. Eur J Clin Invest 22(5):319–325

    Article  PubMed  CAS  Google Scholar 

  • Kimura T, Nojiri T, Hino J, Hosoda H, Miura K, Shintani Y, Inoue M, Zenitani M, Takabatake H, Miyazato M, Okumura M, Kangawa K (2016) C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice. Respir Res 17(19)

    Google Scholar 

  • Kistorp C, Raymond I, Pedersen F, Gustafsson F, Faber J, Hildebrandt P (2005) N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular events in older adults. JAMA 293(13):1609–1616

    Article  PubMed  CAS  Google Scholar 

  • Knecht M, Pagel I, Langenickel T, Philipp S, Scheuermann-Freestone M, Willnow T, Bruemmer D, Graf K, Dietz R, Willenbrock R (2002) Increased expression of renal neutral endopeptidase in severe heart failure. Life Sci 71(23):2701–2712

    Article  PubMed  CAS  Google Scholar 

  • Koller KJ, Lowe DG, Bennett GL, Minamino N, Kangawa K, Matsuo H, Goeddel DV (1991) Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science 252(5002):120–123

    Article  PubMed  CAS  Google Scholar 

  • Kostis JB, Packer M, Black HR, Schmieder R, Henry D, Levy E (2004) Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial. Am J Hypertens 17(2):103–111

    Article  PubMed  CAS  Google Scholar 

  • Kroon MH, van den Hurk K, Alssema M, Kamp O, Stehouwer CD, Henry RM, Diamant M, Boomsma F, Nijpels G, Paulus WJ, Dekker JM (2012) Prospective associations of B-type natriuretic peptide with markers of left ventricular function in individuals with and without type 2 diabetes: an 8-year follow-up of the Hoorn Study. Diabetes Care 35(12):2510–2514

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kuhn M (2016) Molecular physiology of membrane guanylyl cyclase receptors. Physiol Rev 96(2):751–804

    Article  PubMed  CAS  Google Scholar 

  • Lang RE, Unger T, Ganten D (1987) Atrial natriuretic peptide: a new factor in blood pressure control. J Hypertens 5(3):255–271

    Article  PubMed  CAS  Google Scholar 

  • Langenickel TH, Buttgereit J, Pagel-Langenickel I, Lindner M, Monti J, Beuerlein K, Al-Saadi N, Plehm R, Popova E, Tank J, Dietz R, Willenbrock R, Bader M (2006) Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B. Proc Natl Acad Sci U S A 103(12):4735–4740

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee CY, Chen HH, Lisy O, Swan S, Cannon C, Lieu HD, Burnett JC Jr (2009) Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects. J Clin Pharmacol 49(6):668–673

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee CY, Huntley BK, McCormick DJ, Ichiki T, Sangaralingham SJ, Lisy O, Burnett JC Jr (2016) Cenderitide: structural requirements for the creation of a novel dual particulate guanylyl cyclase receptor agonist with renal-enhancing in vivo and ex vivo actions. Eur Heart J Cardiovasc Pharmacother 2(2):98–105

    Article  PubMed  CAS  Google Scholar 

  • Lisy O, Jougasaki M, Heublein DM, Schirger JA, Chen HH, Wennberg PW, Burnett JC (1999) Renal actions of synthetic dendroaspis natriuretic peptide. Kidney Int 56(2):502–508

    Article  PubMed  CAS  Google Scholar 

  • Lisy O, Lainchbury JG, Leskinen H, Burnett JC Jr (2001) Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure. Hypertension 37(4):1089–1094

    Article  PubMed  CAS  Google Scholar 

  • Lisy O, Huntley BK, McCormick DJ, Kurlansky PA, Burnett JC Jr (2008) Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP. J Am Coll Cardiol 52(1):60–68

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lu SY, Wang DS, Zhu MZ, Zhang QH, YZ H, Pei JM (2005) Inhibition of hypoxia-induced proliferation and collagen synthesis by vasonatrin peptide in cultured rat pulmonary artery smooth muscle cells. Life Sci 77(1):28–38

    Article  PubMed  CAS  Google Scholar 

  • Luchner A, Stevens TL, Borgeson DD, Redfield M, Wei CM, Porter JG, Burnett JC Jr (1998) Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure. Am J Physiol 274(5 Pt 2):H1684–H1689

    PubMed  CAS  Google Scholar 

  • Luss H, Mitrovic V, Seferovic PM, Simeunovic D, Ristic AD, Moiseyev VS, Forssmann WG, Hamdy AM, Meyer M (2008) Renal effects of ularitide in patients with decompensated heart failure. Am Heart J 155(6):1012 e1011-1018

    Article  CAS  Google Scholar 

  • Maeda K, Tsutamoto T, Wada A, Hisanaga T, Kinoshita M (1998) Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction. Am Heart J 135(5 Pt 1):825–832

    Article  PubMed  CAS  Google Scholar 

  • Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, Omland T, Storrow AB, Abraham WT, AH W, Clopton P, Steg PG, Westheim A, Knudsen CW, Perez A, Kazanegra R, Herrmann HC, McCullough PA (2002) Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347(3):161–167

    Article  PubMed  CAS  Google Scholar 

  • Marcus LS, Hart D, Packer M, Yushak M, Medina N, Danziger RS, Heitjan DF, Katz SD (1996) Hemodynamic and renal excretory effects of human brain natriuretic peptide infusion in patients with congestive heart failure. A double-blind, placebo-controlled, randomized crossover trial. Circulation 94(12):3184–3189

    Article  PubMed  CAS  Google Scholar 

  • Marin-Grez M, Fleming JT, Steinhausen M (1986) Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney. Nature 324(6096):473–476

    Article  PubMed  CAS  Google Scholar 

  • Martin FL, Sangaralingham SJ, Huntley BK, McKie PM, Ichiki T, Chen HH, Korinek J, Harders GE, Burnett JC Jr (2012) CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart. PLoS One 7(12):e52422

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mathisen P, Hall C, Simonsen S (1993) Comparative study of atrial peptides ANF (1-98) and ANF (99-126) as diagnostic markers of atrial distension in patients with cardiac disease. Scand J Clin Lab Invest 53(1):41–49

    Article  PubMed  CAS  Google Scholar 

  • Matsukawa N, Grzesik WJ, Takahashi N, Pandey KN, Pang S, Yamauchi M, Smithies O (1999) The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A 96(13):7403–7408

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Matsumoto T, Wada A, Tsutamoto T, Omura T, Yokohama H, Ohnishi M, Nakae I, Takahashi M, Kinoshita M (1999) Vasorelaxing effects of atrial and brain natriuretic peptides on coronary circulation in heart failure. Am J Physiol 276(6 Pt 2):H1935–H1942

    PubMed  CAS  Google Scholar 

  • Mattingly MT, Brandt RR, Heublein DM, Wei CM, Nir A, Burnett JC Jr (1994) Presence of C-type natriuretic peptide in human kidney and urine. Kidney Int 46(3):744–747

    Article  PubMed  CAS  Google Scholar 

  • McKie PM, Cataliotti A, Sangaralingham SJ, Ichiki T, Cannone V, Bailey KR, Redfield MM, Rodeheffer RJ, Burnett JC Jr (2011) Predictive utility of atrial, N-terminal pro-atrial, and N-terminal pro-B-type natriuretic peptides for mortality and cardiovascular events in the general community: a 9-year follow-up study. Mayo Clin Proc 86(12):1154–1160

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR (2014) Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 371(11):993–1004

    Article  PubMed  CAS  Google Scholar 

  • Melenovsky V, Kotrc M, Borlaug BA, Marek T, Kovar J, Malek I, Kautzner J (2013) Relationships between right ventricular function, body composition, and prognosis in advanced heart failure. J Am Coll Cardiol 62(18):1660–1670

    Article  PubMed  Google Scholar 

  • Mellin V, Jeng AY, Monteil C, Renet S, Henry JP, Thuillez C, Mulder P (2005) Triple ACE-ECE-NEP inhibition in heart failure: a comparison with ACE and dual ECE-NEP inhibition. J Cardiovasc Pharmacol 46(3):390–397

    Article  PubMed  CAS  Google Scholar 

  • Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, Yamahara K, Taura D, Inuzuka M, Sonoyama T, Nakao K (2009) Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity. Diabetes 58(12):2880–2892

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mulder P, Barbier S, Monteil C, Jeng AY, Henry JP, Renet S, Thuillez C (2004) Sustained improvement of cardiac function and prevention of cardiac remodeling after long-term dual ECE-NEP inhibition in rats with congestive heart failure. J Cardiovasc Pharmacol 43(4):489–494

    Article  PubMed  CAS  Google Scholar 

  • Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED (2007) Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 116(3):238–248

    Article  PubMed  CAS  Google Scholar 

  • Nayer J, Aggarwal P, Galwankar S (2014) Utility of point-of-care testing of natriuretic peptides (brain natriuretic peptide and n-terminal pro-brain natriuretic peptide) in the emergency department. Int J Crit Illn Inj Sci 4(3):209–215

    Article  PubMed  PubMed Central  Google Scholar 

  • Nobata S, Ventura A, Kaiya H, Takei Y (2010) Diversified cardiovascular actions of six homologous natriuretic peptides (ANP, BNP, VNP, CNP1, CNP3, and CNP4) in conscious eels. Am J Physiol Regul Integr Comp Physiol 298(6):R1549–R1559

    Article  PubMed  CAS  Google Scholar 

  • Northridge DB, Currie PF, Newby DE, McMurray JJ, Ford M, Boon NA, Dargie HJ (1999) Placebo-controlled comparison of candoxatril, an orally active neutral endopeptidase inhibitor, and captopril in patients with chronic heart failure. Eur J Heart Fail 1(1):67–72

    Article  PubMed  CAS  Google Scholar 

  • Nussenzveig DR, Lewicki JA, Maack T (1990) Cellular mechanisms of the clearance function of type C receptors of atrial natriuretic factor. J Biol Chem 265(34):20952–20958

    PubMed  CAS  Google Scholar 

  • O’Connor CM, Starling RC, Hernandez AF, Armstrong PW, Dickstein K, Hasselblad V, Heizer GM, Komajda M, Massie BM, McMurray JJ, Nieminen MS, Reist CJ, Rouleau JL, Swedberg K, Adams KF Jr, Anker SD, Atar D, Battler A, Botero R, Bohidar NR, Butler J, Clausell N, Corbalan R, Costanzo MR, Dahlstrom U, Deckelbaum LI, Diaz R, Dunlap ME, Ezekowitz JA, Feldman D, Felker GM, Fonarow GC, Gennevois D, Gottlieb SS, Hill JA, Hollander JE, Howlett JG, Hudson MP, Kociol RD, Krum H, Laucevicius A, Levy WC, Mendez GF, Metra M, Mittal S, Oh BH, Pereira NL, Ponikowski P, Tang WH, Tanomsup S, Teerlink JR, Triposkiadis F, Troughton RW, Voors AA, Whellan DJ, Zannad F, Califf RM (2011) Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med 365(1):32–43

    Article  PubMed  Google Scholar 

  • Ogawa Y, Itoh H, Tamura N, Suga S, Yoshimasa T, Uehira M, Matsuda S, Shiono S, Nishimoto H, Nakao K (1994) Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene. J Clin Invest 93(5):1911–1921

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Oliver PM, Fox JE, Kim R, Rockman HA, Kim HS, Reddick RL, Pandey KN, Milgram SL, Smithies O, Maeda N (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A 94(26):14730–14735

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Omland T, Aakvaag A, Bonarjee VV, Caidahl K, Lie RT, Nilsen DW, Sundsfjord JA, Dickstein K (1996) Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction. Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide. Circulation 93(11):1963–1969

    Article  PubMed  CAS  Google Scholar 

  • Packer M, Califf RM, Konstam MA, Krum H, McMurray JJ, Rouleau JL, Swedberg K (2002) Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE). Circulation 106(8):920–926

    Article  PubMed  CAS  Google Scholar 

  • Packer M, O’Connor C, McMurray JJV, Wittes J, Abraham WT, Anker SD, Dickstein K, Filippatos G, Holcomb R, Krum H, Maggioni AP, Mebazaa A, Peacock WF, Petrie MC, Ponikowski P, Ruschitzka F, van Veldhuisen DJ, Kowarski LS, Schactman M, Holzmeister J (2017) Effect of ularitide on cardiovascular mortality in acute heart failure. N Engl J Med 376(20):1956–1964

    Article  PubMed  CAS  Google Scholar 

  • Pagel-Langenickel I, Bao J, Pang L, Sack MN (2010) The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance. Endocr Rev 31(1):25–51

    Article  PubMed  CAS  Google Scholar 

  • Pandey KN, Pavlou SN, Inagami T (1988) Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis. J Biol Chem 263(26):13406–13413

    PubMed  CAS  Google Scholar 

  • Pfisterer M, Buser P, Rickli H, Gutmann M, Erne P, Rickenbacher P, Vuillomenet A, Jeker U, Dubach P, Beer H, Yoon SI, Suter T, Osterhues HH, Schieber MM, Hilti P, Schindler R, Brunner-La Rocca HP (2009) BNP-guided vs symptom-guided heart failure therapy: the trial of intensified vs standard medical therapy in elderly patients with congestive heart failure (TIME-CHF) randomized trial. JAMA 301(4):383–392

    Article  PubMed  CAS  Google Scholar 

  • Pokreisz P, Vandenwijngaert S, Bito V, Van den Bergh A, Lenaerts I, Busch C, Marsboom G, Gheysens O, Vermeersch P, Biesmans L, Liu X, Gillijns H, Pellens M, Van Lommel A, Buys E, Schoonjans L, Vanhaecke J, Verbeken E, Sipido K, Herijgers P, Bloch KD, Janssens SP (2009) Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice. Circulation 119(3):408–416

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37(27):2129–2200

    Article  PubMed  Google Scholar 

  • Potter LR (2011) Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases. Pharmacol Ther 130(1):71–82

    Article  PubMed  CAS  Google Scholar 

  • Potter LR, Hunter T (1998) Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor. J Biol Chem 273(25):15533–15539

    Article  PubMed  CAS  Google Scholar 

  • Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM (2009) Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol 191:341–366

    Article  CAS  Google Scholar 

  • Publication Committee for the VMAC Investigators (Vasodilation in the Management of Acute CHF) (2002) Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. JAMA 287(12):1531–1540

    Google Scholar 

  • Rademaker MT, Richards AM (2005) Cardiac natriuretic peptides for cardiac health. Clin Sci (Lond) 108(1):23–36

    Article  CAS  Google Scholar 

  • Rademaker MT, Charles CJ, Kosoglou T, Protter AA, Espiner EA, Nicholls MG, Richards AM (1997) Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure. Am J Physiol 273(5 Pt 2):H2372–H2379

    PubMed  CAS  Google Scholar 

  • Raine AE, Erne P, Burgisser E, Muller FB, Bolli P, Burkart F, Buhler FR (1986) Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N Engl J Med 315(9):533–537

    Article  PubMed  CAS  Google Scholar 

  • Ramos HR, Birkenfeld AL, de Bold AJ (2015) INTERACTING DISCIPLINES: cardiac natriuretic peptides and obesity: perspectives from an endocrinologist and a cardiologist. Endocr Connect 4(3):R25–R36

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Richards AM, Crozier IG, Espiner EA, Yandle TG, Nicholls MG (1993) Plasma brain natriuretic peptide and endopeptidase 24.11 inhibition in hypertension. Hypertension 22(2):231–236

    Article  PubMed  CAS  Google Scholar 

  • Richards M, Di Somma S, Mueller C, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, AH W, Clopton P, Filippatos GS, Anand I, Ng L, Daniels LB, Neath SX, Shah K, Christenson R, Hartmann O, Anker SD, Maisel A (2013) Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients: results from the BACH Study (Biomarkers in ACute Heart Failure). JACC Heart Fail 1(3):192–199

    Article  PubMed  Google Scholar 

  • Roberts E, Ludman AJ, Dworzynski K, Al-Mohammad A, Cowie MR, McMurray JJ, Mant J (2015) The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting. BMJ 350:h910

    Article  PubMed  PubMed Central  Google Scholar 

  • Ruskoaho H, Leskinen H, Magga J, Taskinen P, Mantymaa P, Vuolteenaho O, Leppaluoto J (1997) Mechanisms of mechanical load-induced atrial natriuretic peptide secretion: role of endothelin, nitric oxide, and angiotensin II. J Mol Med (Berl) 75(11–12):876–885

    Article  CAS  Google Scholar 

  • Sackner-Bernstein JD, Skopicki HA, Aaronson KD (2005) Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure. Circulation 111(12):1487–1491

    Article  PubMed  CAS  Google Scholar 

  • Saito H, Ogihara T, Nakamaru M, Hara H, Higaki J, Rakugi H, Tateyama H, Minamino T, Iinuma K, Kumahara Y (1987) Hemodynamic, renal, and hormonal responses to alpha-human atrial natriuretic peptide in patients with congestive heart failure. Clin Pharmacol Ther 42(2):142–147

    Article  PubMed  CAS  Google Scholar 

  • Schirger JA, Heublein DM, Chen HH, Lisy O, Jougasaki M, Wennberg PW, Burnett JC Jr (1999) Presence of Dendroaspis natriuretic peptide-like immunoreactivity in human plasma and its increase during human heart failure. Mayo Clin Proc 74(2):126–130

    Article  PubMed  CAS  Google Scholar 

  • Schlueter N, de Sterke A, Willmes DM, Spranger J, Jordan J, Birkenfeld AL (2014) Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacol Ther 144(1):12–27

    Article  PubMed  CAS  Google Scholar 

  • Schrier RW, Abraham WT (1999) Hormones and hemodynamics in heart failure. N Engl J Med 341(8):577–585

    Article  PubMed  CAS  Google Scholar 

  • Schroter J, Zahedi RP, Hartmann M, Gassner B, Gazinski A, Waschke J, Sickmann A, Kuhn M (2010) Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern. Febs J 277(11):2440–2453

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schweitz H, Vigne P, Moinier D, Frelin C, Lazdunski M (1992) A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). J Biol Chem 267(20):13928–13932

    PubMed  CAS  Google Scholar 

  • Sengenes C, Berlan M, De Glisezinski I, Lafontan M, Galitzky J (2000) Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J 14(10):1345–1351

    Article  PubMed  CAS  Google Scholar 

  • Solomon SD, Zile M, Pieske B, Voors A, Shah A, Kraigher-Krainer E, Shi V, Bransford T, Takeuchi M, Gong J, Lefkowitz M, Packer M, McMurray JJ (2012) The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial. Lancet 380(9851):1387–1395

    Article  PubMed  CAS  Google Scholar 

  • Solomon SD, Claggett B, Desai AS, Packer M, Zile M, Swedberg K, Rouleau JL, Shi VC, Starling RC, Kozan O, Dukat A, Lefkowitz MP, McMurray JJ (2016) Influence of ejection fraction on outcomes and efficacy of Sacubitril/Valsartan (LCZ696) in heart failure with reduced ejection fraction: the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure (PARADIGM-HF) trial. Circ Heart Fail 9(3):e002744

    Article  PubMed  CAS  Google Scholar 

  • Solomon SD, Rizkala AR, Gong J, Wang W, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, Desai AS, Shi VC, Lefkowitz MP, McMurray JJV (2017) Angiotensin receptor neprilysin inhibition in heart failure with preserved ejection fraction: rationale and design of the PARAGON-HF trial. JACC Heart Fail 5(7):471–482

    Article  PubMed  Google Scholar 

  • Stephenson SL, Kenny AJ (1987a) The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11. Biochem J 243(1):183–187

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Stephenson SL, Kenny AJ (1987b) Metabolism of neuropeptides. Hydrolysis of the angiotensins, bradykinin, substance P and oxytocin by pig kidney microvillar membranes. Biochem J 241(1):237–247

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sudoh T, Kangawa K, Minamino N, Matsuo H (1988) A new natriuretic peptide in porcine brain. Nature 332(6159):78–81

    Article  PubMed  CAS  Google Scholar 

  • Sudoh T, Minamino N, Kangawa K, Matsuo H (1990) C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 168(2):863–870

    Article  PubMed  CAS  Google Scholar 

  • Tamura N, Ogawa Y, Chusho H, Nakamura K, Nakao K, Suda M, Kasahara M, Hashimoto R, Katsuura G, Mukoyama M, Itoh H, Saito Y, Tanaka I, Otani H, Katsuki M (2000) Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc Natl Acad Sci U S A 97(8):4239–4244

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tamura N, Doolittle LK, Hammer RE, Shelton JM, Richardson JA, Garbers DL (2004) Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc Natl Acad Sci U S A 101(49):17300–17305

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Toth M, Vuorinen KH, Vuolteenaho O, Hassinen IE, Uusimaa PA, Leppaluoto J, Ruskoaho H (1994) Hypoxia stimulates release of ANP and BNP from perfused rat ventricular myocardium. Am J Physiol 266(4 Pt 2):H1572–H1580

    PubMed  CAS  Google Scholar 

  • Tremblay J, Desjardins R, Hum D, Gutkowska J, Hamet P (2002) Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases. Mol Cell Biochem 230(1-2):31–47

    Article  PubMed  CAS  Google Scholar 

  • Troughton RW, Frampton CM, Yandle TG, Espiner EA, Nicholls MG, Richards AM (2000) Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet 355(9210):1126–1130

    Article  PubMed  CAS  Google Scholar 

  • Troughton RW, Frampton CM, Brunner-La Rocca HP, Pfisterer M, Eurlings LW, Erntell H, Persson H, O’Connor CM, Moertl D, Karlstrom P, Dahlstrom U, Gaggin HK, Januzzi JL, Berger R, Richards AM, Pinto YM, Nicholls MG (2014) Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: an individual patient meta-analysis. Eur Heart J 35(23):1559–1567

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tsutamoto T, Bito K, Kinoshita M (1989) Plasma atrial natriuretic polypeptide as an index of left ventricular end-diastolic pressure in patients with chronic left-sided heart failure. Am Heart J 117(3):599–606

    Article  PubMed  CAS  Google Scholar 

  • Tsutamoto T, Kanamori T, Wada A, Kinoshita M (1992) Uncoupling of atrial natriuretic peptide extraction and cyclic guanosine monophosphate production in the pulmonary circulation in patients with severe heart failure. J Am Coll Cardiol 20(3):541–546

    Article  PubMed  CAS  Google Scholar 

  • Tsutamoto T, Wada A, Maeda K, Mabuchi N, Hayashi M, Tsutsui T, Ohnishi M, Sawaki M, Fujii M, Matsumoto T, Matsui T, Kinoshita M (2001) Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol 37(5):1228–1233

    Article  PubMed  CAS  Google Scholar 

  • Ueno H, Haruno A, Morisaki N, Furuya M, Kangawa K, Takeshita A, Saito Y (1997) Local expression of C-type natriuretic peptide markedly suppresses neointimal formation in rat injured arteries through an autocrine/paracrine loop. Circulation 96(7):2272–2279

    Article  PubMed  CAS  Google Scholar 

  • Velagaleti RS, Gona P, Larson MG, Wang TJ, Levy D, Benjamin EJ, Selhub J, Jacques PF, Meigs JB, Tofler GH, Vasan RS (2010) Multimarker approach for the prediction of heart failure incidence in the community. Circulation 122(17):1700–1706

    Article  PubMed  PubMed Central  Google Scholar 

  • Vlasuk GP, Miller J, Bencen GH, Lewicki JA (1986) Structure and analysis of the bovine atrial natriuretic peptide precursor gene. Biochem Biophys Res Commun 136(1):396–403

    Article  PubMed  CAS  Google Scholar 

  • Volpe M (1992) Atrial natriuretic peptide and the baroreflex control of circulation. Am J Hypertens 5(7):488–493

    Article  PubMed  CAS  Google Scholar 

  • von Haehling S, Jankowska EA, Morgenthaler NG, Vassanelli C, Zanolla L, Rozentryt P, Filippatos GS, Doehner W, Koehler F, Papassotiriou J, Kremastinos DT, Banasiak W, Struck J, Ponikowski P, Bergmann A, Anker SD (2007) Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure. J Am Coll Cardiol 50(20):1973–1980

    Article  CAS  Google Scholar 

  • von Lueder TG, Sangaralingham SJ, Wang BH, Kompa AR, Atar D, Burnett JC Jr, Krum H (2013) Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure. Circ Heart Fail 6(3):594–605

    Article  Google Scholar 

  • Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, Jacques PF, Rifai N, Selhub J, Robins SJ, Benjamin EJ, D’Agostino RB, Vasan RS (2006) Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med 355(25):2631–2639

    Article  PubMed  CAS  Google Scholar 

  • Weber M, Hamm C (2006) Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine. Heart 92(6):843–849

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC Jr (1993a) Natriuretic peptide system in human heart failure. Circulation 88(3):1004–1009

    Article  PubMed  CAS  Google Scholar 

  • Wei CM, Kim CH, Miller VM, Burnett JC Jr (1993b) Vasonatrin peptide: a unique synthetic natriuretic and vasorelaxing peptide. J Clin Invest 92(4):2048–2052

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Weidmann P, Hasler L, Gnadinger MP, Lang RE, Uehlinger DE, Shaw S, Rascher W, Reubi FC (1986) Blood levels and renal effects of atrial natriuretic peptide in normal man. J Clin Invest 77(3):734–742

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Westheim AS, Bostrom P, Christensen CC, Parikka H, Rykke EO, Toivonen L (1999) Hemodynamic and neuroendocrine effects for candoxatril and frusemide in mild stable chronic heart failure. J Am Coll Cardiol 34(6):1794–1801

    Article  PubMed  CAS  Google Scholar 

  • Wilkins MR, Settle SL, Kirk JE, Taylor SA, Moore KP, Unwin RJ (1992) Response to atrial natriuretic peptide, endopeptidase 24.11 inhibitor and C-ANP receptor ligand in the rat. Br J Pharmacol 107(1):50–57

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wong NL, Wong EF, GH A, DC H (1988) Effect of alpha- and beta-adrenergic stimulation on atrial natriuretic peptide release in vitro. Am J Physiol 255(3 Pt 1):E260–E264

    PubMed  CAS  Google Scholar 

  • Xiong B, Nie D, Cao Y, Zou Y, Yao Y, Tan J, Qian J, Rong S, Wang C, Huang J (2017) Clinical and hemodynamic effects of endothelin receptor antagonists in patients with heart failure. Int Heart J 58(3):400–408

    Article  PubMed  Google Scholar 

  • Yan W, Wu F, Morser J, Wu Q (2000) Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. Proc Natl Acad Sci U S A 97(15):8525–8529

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL (2013) 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 128(16):e240–e327

    Article  PubMed  Google Scholar 

  • Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos G, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C (2016) 2016 ACC/AHA/HFSA focused update on new pharmacological therapy for heart failure: An update of the 2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Am Coll Cardiol 68(13):1476–1488

    Article  PubMed  Google Scholar 

  • Yoshimura M, Yasue H, Morita E, Sakaino N, Jougasaki M, Kurose M, Mukoyama M, Saito Y, Nakao K, Imura H (1991) Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure. Circulation 84(4):1581–1588

    Article  PubMed  CAS  Google Scholar 

  • Zile MR, Claggett BL, Prescott MF, McMurray JJ, Packer M, Rouleau JL, Swedberg K, Desai AS, Gong J, Shi VC, Solomon SD (2016) Prognostic implications of changes in N-terminal pro-B-type natriuretic peptide in patients with heart failure. J Am Coll Cardiol 68(22):2425–2436

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiovascular/Metabolic/Renal, Covance Clinical and Periapproval Services AG, Zurich, Switzerland

    Ines Pagel-Langenickel

Authors
  1. Ines Pagel-Langenickel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ines Pagel-Langenickel .

Editor information

Editors and Affiliations

  1. Department of Clinical Sciences and Education, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pagel-Langenickel, I. (2018). Evolving Role of Natriuretic Peptides from Diagnostic Tool to Therapeutic Modality. In: Islam, M. (eds) Heart Failure: From Research to Clinical Practice. Advances in Experimental Medicine and Biology(), vol 1067. Springer, Cham. https://doi.org/10.1007/5584_2018_143

Download citation

  • DOI: https://doi.org/10.1007/5584_2018_143

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-78279-9

  • Online ISBN: 978-3-319-78280-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation